Italian scientists claim world-first coronavirus vaccine breakthrough

An Italian coronavirus vaccine has antibodies generated in mice that work on human cells, according to tests carried out at Rome’s infectious-disease Spallanzani Hospital. (Reuters/File Photo)
Short Url
Updated 05 May 2020
Follow

Italian scientists claim world-first coronavirus vaccine breakthrough

  • A coronavirus disease (COVID-19) candidate vaccine has neutralized the virus in human cells for the first time

ROME: An Italian coronavirus vaccine has antibodies generated in mice that work on human cells, according to tests carried out at Rome’s infectious-disease Spallanzani Hospital.

Luigi Aurisicchio, CEO of  Takis, the firm developing the medication, said that a coronavirus disease (COVID-19) candidate vaccine has neutralized the virus in human cells for the first time.

“This is the most advanced stage of testing of a candidate vaccine created in Italy,” Aurisicchio told the Italian newsagency ANSA. “Human tests are expected after this summer,” he added.

“According to Spallanzani Hospital, as far as we know we are the first in the world so far to have demonstrated a neutralization of the coronavirus by a vaccine. We expect this to happen in humans too,” said Aurisicchio.

Opinion

This section contains relevant reference points, placed in (Opinion field)

He explains that Takis is exploring “more interesting technological platforms with LineaRx, an American company.

“We are working hard for a vaccine coming from Italian research, with an all-Italian and innovative technology, tested in Italy and made available to everyone. In order to reach this goal we need the support of national and international institutions and partners who may help us speed up the process.”

Aurisicchio added: “This is not a competition. If we join our forces and skills together we can all win against coronavirus.”

Italian researchers describe the results “encouraging and well beyond expectations.”

After a single vaccination, the mice developed antibodies that can block the virus from infecting human cells, Aurisicchio said.

After observing that the five vaccine candidates generated a large number of antibodies, researchers selected the two with the best results.

Serum was isolated from the antibody-rich blood; it was then analyzed in the virology laboratory of the Spallanzani Institute, one of the most advanced establishments in Europe. The next step now is to understand how much the immune response lasts.

All of the vaccine candidates currently being developed are based on the material genetic of DNA protein “spike”, the molecular tip used by the coronavirus to enter human cells.

They are injected with the so-called “electroporation” technique, which consists of an intramuscular injection followed by a brief electrical impulse, helping the vaccine break into the cells and activating the immune system.

Researchers believe that this makes their vaccine particularly effective for generating functional antibodies against the “spike” protein, in particular in the lung cells, which are the most vulnerable to coronavirus.  

“So far, the immunity generated by most of our five vaccine candidates has an effect on the virus. We expect even better results after the second vaccination,” said Dr Emanuele Marra from Takis.

Marra added that those vaccine candidates could adapt to any COVID-19 evolutions and its possible mutations.

“We are already working on a trial version in case the virus accumulates mutations and becomes invisible to the immune system. For this purpose, we use the same concept we use in developing cancer vaccines,” he said.


Erdogan ally floats Turkiye constitutional amendment to let him extend his tenure

Updated 8 sec ago
Follow

Erdogan ally floats Turkiye constitutional amendment to let him extend his tenure

ANKARA: The main political ally of longstanding Turkish leader Tayyip Erdogan said on Tuesday that a constitutional amendment should be considered to allow the president to run again in elections set for 2028.
After his re-election last year, Erdogan is serving his last term as president unless parliament calls an early election, according to the constitution. He has ruled Turkiye for more than 21 years, first as prime minister and then as president.
“Wouldn’t it be a natural and right choice to have our president elected once again if terror is eradicated, and if a heavy blow is dealt to inflation and Turkiye secures political and economic stability,” said Devlet Bahceli, leader of the Nationalist Movement Party (MHP), which is allied with Erdogan’s ruling AK Party (AKP).
A constitutional amendment to secure Erdogan’s ability to re-run in the presidential elections should be considered, he said in a parliamentary speech to MHP lawmakers.
Bahceli, a staunch nationalist, rattled Turkish politics last month by suggesting that the jailed leader of the outlawed Kurdistan Workers’ Party (PKK) could be allowed to speak in parliament if he announces an end to the group’s insurgency.
Some analysts said the shock suggestion might be motivated by an AKP-MHP desire to win the support of the pro-Kurdish DEM Party, parliament’s third-biggest, for a constitutional change that could boost Erdogan’s prospects in 2028 elections.
A constitutional change can be put to a referendum if 360 lawmakers in the 600-seat parliament back it. An early election also needs the support of 360 MPs.
AKP and its allies have 321 seats while DEM has 57.


A tiny village in India where Kamala Harris has ancestral roots is praying for her victory

Updated 05 November 2024
Follow

A tiny village in India where Kamala Harris has ancestral roots is praying for her victory

THULASENDRAPURAM: The temple reverberated with rhythmic Sanskrit and Tamil hymns, as a Hindu priest held a flame before the god. As this tiny South Indian village gathered to pray for Kamala Harris, a gaggle of reporters jostled for space and camera angles.
There's little to distinguish the village of Thulasendrapuram from any other rural community in Tamil Nadu, except its connection to a woman who could become America's first leader with South Asian roots.
As millions of Americans vote, Harris has people rooting for her from thousands of miles away in a village surrounded by rice paddies and coconut trees, where her mother's family has ancestral ties. They talk about her at the local tea shop. Banners and billboards bearing her face are seen throughout the community.
“Our deity is a very powerful God. If we pray well to him, he will make her victorious,” said M. Natarajan, the temple priest that led the prayers in front of the image of Hindu deity Ayyanar, a form of Lord Shiva.
Harris’ maternal grandfather was born in the village, about 350 kilometers (215 miles) from the southern coastal city of Chennai, more than 100 years ago. As an adult, he moved to Chennai, where he worked as a high-ranking government official until his retirement.
Harris has never visited Thulasendrapuram and she has no living relatives in the village, but people here still venerate the family that made it big in the U.S.
“Our village ancestors' granddaughter is running as a U.S. presidential candidate. Her victory will be happy news for every one of us,” Natarajan said.
The village's sudden fame has helped bring money into the village. Recently, construction began on a water storage tank with funds donated by a local bank. Village residents say it will carry a plaque with Harris’ name.
Harris’ late mother, Shyamala Gopalan, was born in India. After moving to the U.S. to study, she married a Jamaican man, and they named their daughter Kamala, a Sanskrit word for “lotus flower.”
Other than trips during her childhood, Harris hasn’t visited India much — particularly not since becoming vice president — but she has often spoken emotionally about her ties to her late mother’s country of birth. On Tuesday, she released a campaign video highlighting her mother, who arrived in the U.S. at age 19 and became a cancer researcher.
Titled “Mother,” the video ends with a narrator saying: “This daughter of Shyamala, this daughter of the American story, is ready to lead us forward.”
Harris has often talked about how she was guided by the values of her Indian-born grandfather and mother. She has also spoken of her love of south Indian food, especially a type of steamed rice cake called idli.
Harris’ name is engraved in a list of donors — her aunt Sarala Gopalan gave money to the temple in her name — along with that of her grandfather. Outside, a large banner wishes “the daughter of the land” success in the election.
On Tuesday, the village temple also received rare international visitors: two American tourists and one from the U.K., all wearing black t-shirts that said “Kamala Freakin Harris.”
Manikandan Ganesan, a villager who runs a small store near the temple, said Harris’ bid for the presidency has made the village famous. He hopes Harris will eventually visit them.
“Even if she mentioned that she would visit our village, it would make us very happy,” Ganesan said. “Her victory itself will be a big source of happiness for us.”
Village residents also prayed for Harris’ victory in 2020, and set off firecrackers when she became the U.S. Vice President.
For women of the village, the candidate's journey is a source of inspiration.
Local politician Arulmozhi Sudhakar said Harris embodies a significant step toward female empowerment in places like Thulasendrapuram, where a majority of women continue to face discrimination and gender inequality.
“From the time when women were not even allowed to step out of their house, to now a woman from our village contesting in the U.S. presidential election — this brings happiness for us,” Sudhakar said. “The coming generations will see her as a role model to succeed in life.”

Ukraine’s military says it shot down 48 drones and two missiles overnight

Updated 05 November 2024
Follow

Ukraine’s military says it shot down 48 drones and two missiles overnight

KYIV: The Ukrainian military said on Tuesday it shot down 48 out of 79 drones and two missiles launched by Russia overnight.
The air force said the location of 30 other drones had been lost, while another had returned to Russia.


India foreign minister says vandalism of Hindu temples deeply concerning

Updated 05 November 2024
Follow

India foreign minister says vandalism of Hindu temples deeply concerning

  • Vandalism incident happened weeks after Ottawa expelled six Indian diplomats, linking them to killing of Sikh separatist leader in 2023 
  • Canada has accused India of conducting a broad campaign against South Asian dissidents in Canada, which New Delhi denies 

SYDNEY: India foreign minister Subrahmanyam Jaishankar said on Tuesday the vandalism of a Hindu temple in Canada on Monday was deeply concerning.
“What happened yesterday at the Hindu temple in Canada was obviously deeply concerning,” he told reporters in the Australian capital Canberra while on an official visit.
The incident happened weeks after Ottawa expelled six Indian diplomats, linking them to the killing of a Sikh separatist leader in 2023 in Canada. Canada has accused the Indian government of conducting a broad campaign against South Asian dissidents in Canada, which New Delhi denies.
The incident has increased tensions between Canada and India, and between Sikh separatists and Indian diplomats.
Two Hindu temples were also vandalized in Canberra last month, which Australian Foreign Minister Penny Wong said was upsetting for members of the Indian community.
“People across Australia have a right to be safe and respected, people also have a right to peaceful protest, people have a right to express their views peacefully,” she told reporters.
“We draw a line between that and violence, incitement of hatred or vandalism,” she added.
Wong said Australia had expressed its views to India about Canada’s allegations over the targeting of Sikh separatists, and Canberra respected Canada’s judicial process. Jaishankar said it was unacceptable that Indian diplomats had been placed under surveillance by Canada.
“Canada has developed a pattern of making allegations without providing specifics,” he said.


India foreign minister says vandalism of Hindu temples deeply concerning

Updated 05 November 2024
Follow

India foreign minister says vandalism of Hindu temples deeply concerning

  • Canada has accused the Indian government of conducting a broad campaign against South Asian dissidents in Canada, which New Delhi denies

SYDNEY: India foreign minister Subrahmanyam Jaishankar said on Tuesday the vandalism of a Hindu temple in Canada on Monday was deeply concerning.
“What happened yesterday at the Hindu temple in Canada was obviously deeply concerning,” he told reporters in the Australian capital Canberra while on an official visit.
The incident happened weeks after Ottawa expelled six Indian diplomats, linking them to the killing of a Sikh separatist leader in 2023 in Canada. Canada has accused the Indian government of conducting a broad campaign against South Asian dissidents in Canada, which New Delhi denies.
The incident has increased tensions between Canada and India, and between Sikh separatists and Indian diplomats.
Two Hindu temples were also vandalized in Canberra last month, which Australian Foreign Minister Penny Wong said was upsetting for members of the Indian community.
“People across Australia have a right to be safe and respected, people also have a right to peaceful protest, people have a right to express their views peacefully,” she told reporters.
“We draw a line between that and violence, incitement of hatred or vandalism,” she added.
Wong said Australia had expressed its views to India about Canada’s allegations over the targeting of Sikh separatists, and Canberra respected Canada’s judicial process. Jaishankar said it was unacceptable that Indian diplomats had been placed under surveillance by Canada.
“Canada has developed a pattern of making allegations without providing specifics,” he said.