Italian scientists claim world-first coronavirus vaccine breakthrough

An Italian coronavirus vaccine has antibodies generated in mice that work on human cells, according to tests carried out at Rome’s infectious-disease Spallanzani Hospital. (Reuters/File Photo)
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Updated 05 May 2020
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Italian scientists claim world-first coronavirus vaccine breakthrough

  • A coronavirus disease (COVID-19) candidate vaccine has neutralized the virus in human cells for the first time

ROME: An Italian coronavirus vaccine has antibodies generated in mice that work on human cells, according to tests carried out at Rome’s infectious-disease Spallanzani Hospital.

Luigi Aurisicchio, CEO of  Takis, the firm developing the medication, said that a coronavirus disease (COVID-19) candidate vaccine has neutralized the virus in human cells for the first time.

“This is the most advanced stage of testing of a candidate vaccine created in Italy,” Aurisicchio told the Italian newsagency ANSA. “Human tests are expected after this summer,” he added.

“According to Spallanzani Hospital, as far as we know we are the first in the world so far to have demonstrated a neutralization of the coronavirus by a vaccine. We expect this to happen in humans too,” said Aurisicchio.

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He explains that Takis is exploring “more interesting technological platforms with LineaRx, an American company.

“We are working hard for a vaccine coming from Italian research, with an all-Italian and innovative technology, tested in Italy and made available to everyone. In order to reach this goal we need the support of national and international institutions and partners who may help us speed up the process.”

Aurisicchio added: “This is not a competition. If we join our forces and skills together we can all win against coronavirus.”

Italian researchers describe the results “encouraging and well beyond expectations.”

After a single vaccination, the mice developed antibodies that can block the virus from infecting human cells, Aurisicchio said.

After observing that the five vaccine candidates generated a large number of antibodies, researchers selected the two with the best results.

Serum was isolated from the antibody-rich blood; it was then analyzed in the virology laboratory of the Spallanzani Institute, one of the most advanced establishments in Europe. The next step now is to understand how much the immune response lasts.

All of the vaccine candidates currently being developed are based on the material genetic of DNA protein “spike”, the molecular tip used by the coronavirus to enter human cells.

They are injected with the so-called “electroporation” technique, which consists of an intramuscular injection followed by a brief electrical impulse, helping the vaccine break into the cells and activating the immune system.

Researchers believe that this makes their vaccine particularly effective for generating functional antibodies against the “spike” protein, in particular in the lung cells, which are the most vulnerable to coronavirus.  

“So far, the immunity generated by most of our five vaccine candidates has an effect on the virus. We expect even better results after the second vaccination,” said Dr Emanuele Marra from Takis.

Marra added that those vaccine candidates could adapt to any COVID-19 evolutions and its possible mutations.

“We are already working on a trial version in case the virus accumulates mutations and becomes invisible to the immune system. For this purpose, we use the same concept we use in developing cancer vaccines,” he said.


Floods displace 122,000 people in Malaysia

Updated 53 min 58 sec ago
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Floods displace 122,000 people in Malaysia

  • The number surpassed the 118,000 displaced during one of the country’s worst floodings in 2014

Kuala Lumpur: More than 122,000 people have been forced out of their homes as massive floods caused by relentless rains swept through Malaysia’s northern states, disaster officials said Saturday.
The number surpassed the 118,000 displaced during one of the country’s worst floodings in 2014, and disaster officials feared it could rise further as there was no let-up in torrential downpours.
The death toll remained at four recorded across Kelantan, Terengganu and Sarawak.
Kelantan state bore the brunt of the flooding, accounting for 63 percent of the 122,631 people displaced, according to data from the National Disaster Management Agency.
There were nearly 35,000 people evacuated in Terengganu, with the rest of the displacements reported from seven other states.
Heavy rains, which began early this week, continued to hammer Pasir Puteh town in Kelantan, where people could be seen walking through streets inundated with hip-deep waters.
“My area has been flooded since Wednesday. The water has already reached my house corridor and is just two inches away from coming inside,” Pasir Puteh resident and school janitor Zamrah Majid, 59, told AFP.
“Luckily, I moved my two cars to a higher ground before the water level rose.”
She said she allowed her grandchildren to play in the water in front of his house because it was still shallow.
“But if the water gets higher, it would be dangerous, I’m afraid they might get swept away,” she added.
“I haven’t received any assistance yet, whether it’s welfare or other kinds of help.”
Muhammad Zulkarnain, 27, who is living with his parents in Pasir Puteh, said they were isolated.
“There’s no way in or out of for any vehicles to enter my neighborhood,” he told AFP.
“Of course I’m scared... Luckily we have received some assistance from NGOs, they gave us food supplies like biscuits, instant noodles, and eggs.”
Floods are an annual phenomenon in the Southeast Asian nation of 34 million people due to the northeast monsoon that brings heavy rain from November to March.
Thousands of emergency services personnel have been deployed in flood-prone states along with rescue boats, four-wheel-drive vehicles and helicopters, said Deputy Prime Minister Ahmad Zahid Hamidi, who chairs the National Disaster Management Committee.


China coast guard says it conducted patrols around Scarborough Shoal in South China Sea

Updated 30 November 2024
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China coast guard says it conducted patrols around Scarborough Shoal in South China Sea

  • Tensions between China and the Philippines over disputed areas of the South China Sea have escalated throughout the year, particularly over the Scarborough Shoal

BEIJING: China’s coast guard said it had conducted patrols around the Scarborough Shoal in the South China Sea on Saturday to safeguard China’s territorial rights.
The coast guard has continued to strengthen law enforcement patrols in the territorial waters and surrounding areas of Scarborough Shoal since the beginning of November, and “resolutely safeguarding the country’s territorial sovereignty and maritime rights and interests,” it said in a statement.
Tensions between China and the Philippines over disputed areas of the South China Sea have escalated throughout the year, particularly over the Scarborough Shoal.


13 more killed in Pakistan sectarian fighting

Updated 30 November 2024
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13 more killed in Pakistan sectarian fighting

  • Fresh fighting broke out last Thursday when two separate convoys of Shiite Muslims traveling under police escort were ambushed, killing more than 40

Peshawar: Sectarian feuding in northwest Pakistan killed 13 more people, a local government official said Saturday, as warring Sunnis and Shiites defied repeated ceasefire orders in recent conflict claiming 124 lives.
Pakistan is a Sunni-majority country, but Kurram district — in Khyber Pakhtunkhwa province, near the border with Afghanistan — has a large Shiite population and the communities have clashed for decades.
Fresh fighting broke out last Thursday when two separate convoys of Shiite Muslims traveling under police escort were ambushed, killing more than 40.
Since then 10 days of fighting with light and heavy weapons has brought the region to a standstill, with major roads closed and mobile phone services cut as the death toll surged.
A Kurram local government official put the death toll at 124 on Saturday after 13 more people were killed in the past two days.
Two were Sunni and 11 Shiite, he said, whilst more than 50 people have been wounded in fresh fighting which continued Saturday morning.
“There is a severe lack of trust between the two sides, and neither tribe is willing to comply with government orders to cease hostilities,” he told AFP, speaking on condition of anonymity.
“Police report that many people want to flee the area due to the violence, but the deteriorating security situation makes it impossible,” he added.
A seven-day ceasefire deal was announced by the provincial government last weekend but failed to hold. Another 10-day truce was brokered Wednesday but it also failed to stymie the fighting.
A senior security official in the provincial capital of Peshawar, also speaking anonymously, confirmed the total death toll of 124.
“There is a fear of more fatalities,” he said. “None of the provincial government’s initiated measures have been fully implemented to restore peace.”
Police have regularly struggled to control violence in Kurram, which was part of the semi-autonomous Federally Administered Tribal Areas until it was merged with Khyber Pakhtunkhwa in 2018.
The Human Rights Commission of Pakistan said 79 people had been killed in the region between July and October in sectarian clashes.
The feuding is generally rekindled by disputes over land in the rugged mountainous region, and fueled by underlying tensions between the communities adhering to different sects of Islam.


Schools shut as heavy storm approaches India coast

Updated 30 November 2024
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Schools shut as heavy storm approaches India coast

  • Cyclonic storm Fengal is forecast to make landfall in Tamil Nadu state with sustained winds of 70-80 kilometers an hour
  • The forecast urged fishing crews to stay off the water and predicted surging waves of one meter that posed a flood risk

BENGALURU: Schools in India’s south were shut and hundreds of people moved inland to storm shelters ahead of a powerful cyclone storm set to hit the region on Saturday.
Cyclonic storm Fengal is forecast to make landfall in Tamil Nadu state with sustained winds of 70-80 kilometers an hour (43-50 mph) in the afternoon, India’s weather bureau said.
The forecast urged fishing crews to stay off the water and predicted surging waves of one meter (three feet) that posed a flood risk to low-lying coastal areas.
Schools and colleges in numerous districts across Tamil Nadu were shut and at least 471 people had been moved to relief camps, the Economic Times newspaper reported.
Cyclones — the equivalent of hurricanes in the North Atlantic or typhoons in the northwestern Pacific — are a regular and deadly menace in the northern Indian Ocean.
Fengal skirted the coast of Sri Lanka earlier this week, killing at least 12 people including six children.
Scientists have warned that storms are becoming more powerful as the world heats up due to climate change driven by burning fossil fuels.
Warmer ocean surfaces release more water vapor, which provides additional energy for storms, strengthening winds.
A warming atmosphere also allows them to hold more water, boosting heavy rainfall.
But better forecasting and more effective evacuation planning have dramatically reduced death tolls.


Thailand flooding kills nine, displaces thousands

Updated 30 November 2024
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Thailand flooding kills nine, displaces thousands

  • ‘Very heavy rain’ could continue to affect some areas of the country’s south through next week
  • The government has deployed rescue teams to assist affected residents

BANGKOK: Flooding driven by heavy rains in southern Thailand has killed nine people and displaced more than 13,000, officials said Saturday, as rescue teams using boats and jet skis worked to reach stranded residents.
Local media footage showed residents wading through murky, chest-deep water and cars submerged in flooded streets.
“Flooding across eight provinces in southern Thailand has affected 553,921 households and claimed nine lives, prompting agencies to mobilize urgent assistance,” the country’s disaster agency said on its official Facebook page.
More than 13,000 people had been forced to flee their homes, with temporary shelters set up in schools and temples, it added.
Nampa, a resident of coastal Songkhla province, told state broadcaster Thai PBS she was concerned about the dwindling food supplies.
“We are doing fine now, but I am not sure how long can we stay in this condition,” she said.
Two hospitals in nearby Pattani province suspended operations to prevent floodwaters from damaging medical facilities.
In neighboring north Malaysia, the rains have forced the evacuation of at least 80,000 people to temporary shelters this week, with disaster officials there saying at least four people have been killed.
The Thai Meteorological Department has warned that “very heavy rain” could continue to affect some areas of the country’s south through next week.
The government has deployed rescue teams to assist affected residents and designated 50 million baht ($1.7 million) in flood relief for each province.
Thai Prime Minister Paetongtarn Shinawatra said Friday on social media platform X that the goal was to “restore normalcy as quickly as possible.”
While Thailand experiences annual monsoon rains, scientists say man-made climate change is causing more intense weather patterns that can make destructive floods more likely.
Widespread flooding across the country in 2011 killed more than 500 people and damaged millions of homes.