COVID-19 mutations helping virus spread in humans: UK scientists

A police officer wears a thermal headgear to monitor the temperature of commuters in New Delhi. (Reuters)
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Updated 12 May 2020
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COVID-19 mutations helping virus spread in humans: UK scientists

  • The nature of COVID-19’s spike proteins are already thought to be the key reason why it was able to make the leap from a different species, widely thought to be bats, to humans in the first place

LONDON: UK scientists have suggested that COVID-19 may be mutating, heightening fears that the virus is adapting to being carried by humans.
In an unpublished study conducted by a team of researchers at the London School of Hygiene and Tropical Medicine, more than 5,300 coronavirus genomes were analyzed from samples taken from 62 countries.
The results of the study, which has not yet been peer-reviewed, found that one of two different spike protein mutations were found in 810 cases worldwide, with one in particular discovered in 788 cases.
The prevalence of the two mutations suggest that genetic changes in the makeup of the virus, specifically in the spike proteins that allow virus cells to latch on to and infect human cells, are a sign that COVID-19 is becoming more adept at passing from person to person. This could have far-reaching implications for how scientists develop vaccines and treatments.
The study added that spike protein mutations are relatively rare, and that mostly, COVID-19’s structure has remained stable throughout the pandemic.
It said though it is as yet unclear how the mutations the researchers have observed affect the disease’s ability to spread, the fact that the mutations are occurring independently across different regions suggests that they are playing at least some part in aiding transmission.
The study’s lead author, Martin Hibberd, professor of emerging infectious diseases at the London School of Hygiene and Tropical Medicine, said the findings are proof of the need to study the pathogen in case more dangerous mutations emerge.
“This is exactly what we need to look out for,” he added. “People are making vaccines and other therapies against this spike protein because it seems a very good target. We need to keep an eye on it and make sure that any mutations don’t invalidate any of these approaches.”
Part of what makes mutations in virus spike proteins significant, especially in the case of COVID-19, is that disrupting their function is one of the key lines of research in the quest to develop vaccines.
Major changes to these proteins through mutation, altering their behavior or potency, risk not only making the virus more aggressive as it evolves, but also undoing months of careful research into negating its effects on people.
The nature of COVID-19’s spike proteins are already thought to be the key reason why it was able to make the leap from a different species, widely thought to be bats, to humans in the first place.
It is also thought to be the reason why COVID-19 has proven to be a more contagious disease than the SARS coronavirus, which caused a smaller epidemic in Asia in 2002, on account of being better suited to interaction with human cells.
“This is an early warning,” Hibberd said. “Even if these mutations are not important for vaccines, other mutations might be, and we need to maintain our surveillance so we are not caught out by deploying a vaccine that only works against some strains.”


Toxic smog persists over India’s north; Delhi pollution remains severe

Updated 11 sec ago
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Toxic smog persists over India’s north; Delhi pollution remains severe

NEW DELHI: Residents in India’s northern states woke up to another day of poor air quality on Tuesday, as a layer of dense fog shrouded most of the region, and pollution in the capital Delhi remained severe.
India battles air pollution every winter as cold, heavy air traps dust, emissions, and smoke from farm fires started illegally in the adjoining, farming states of Punjab and Haryana.
The air quality index (AQI) touched a peak of 491 in Delhi on Monday, forcing the government to introduce restrictions on vehicle movement and construction activities, and schools to conduct classes online.
On Tuesday, Delhi’s 24-hour air quality index (AQI) reading was at 488 on a scale of 500, India’s Central Pollution Control Board (CPCB) said, and at least five stations in the capital reported an AQI of 500.
CPCB defines an AQI reading of 0-50 as “good” and above 401 as “severe,” which it says is a risk to healthy people and “seriously impacts” those with existing diseases.
Swiss group IQAir ranked New Delhi as the world’s most polluted city with air quality at a “hazardous” 489, although that was a significant improvement from Monday’s 1,081 reading.
Experts say the scores vary because of a difference in the scale countries adopt to convert pollutant concentrations into AQI, and so the same quantity of a specific pollutant may be translated as different AQI scores in different countries.
India’s weather department said a shift in the fog layer toward the northern state of Uttar Pradesh had helped improve visibility over Delhi.
Visibility dropped to zero meters in Uttar Pradesh’s capital Agra, which lies southeast of Delhi. The Taj Mahal, India’s famed monument of love, has been obscured by toxic smog for nearly a week.
The strict measures to mitigate the impact of high pollution have hurt production at more than 3.4 million micro, small and medium enterprises in the nearby states of Punjab, Haryana and Delhi, local media reported.


35,000 crowd New Zealand’s Parliament grounds in support of Māori rights

Updated 11 min 2 sec ago
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35,000 crowd New Zealand’s Parliament grounds in support of Māori rights

  • For many, it was about something more: a celebration of a resurging Indigenous language and identity that colonization had once almost destroyed

WELLINGTON, New Zealand: As tens of thousands of marchers crowded the streets in New Zealand’s capital Wellington on Tuesday, the throng of people, flags aloft, had the air of a festival or a parade rather than a protest.

They arrived to oppose a law that would reshape the county’s founding treaty between Indigenous Māori and the British Crown.

But for many, it was about something more: a celebration of a resurging Indigenous language and identity that colonization had once almost destroyed.
“Just fighting for the rights that our tūpuna, our ancestors, fought for,” Shanell Bob said as she waited for the march to begin. “We’re fighting for our tamariki, for our mokopuna, so they can have what we haven’t been able to have,” she added, using the Māori words for children and grandchildren.
What was likely the country’s largest-ever protest in support of Māori rights — a subject that has preoccupied modern New Zealand for much of its young history — followed a long tradition of peaceful marches the length of the country that have marked turning points in the history of modern New Zealand.
“We’re going for a walk!” One organizer proclaimed from the stage as crowds gathered at the opposite end of the city from the nation’s Parliament. Some had traveled the length of the country over the past nine days.
For many, the turnout reflected growing solidarity on Indigenous rights from non-Māori. At bus stops during the usual morning commute, people of all ages and races waited with Māori sovereignty flags. Some local schools said they would not register students as absent. The city’s mayor joined the protest.
The bill that marchers were opposing is unpopular and unlikely to become law. But opposition to it has exploded, which marchers said indicated rising knowledge of the Treaty of Waitangi’s promises to Māori among New Zealanders — and a small but vocal backlash from those who are angered by attempts by courts and lawmakers to keep them.
Māori marching for their rights as outlined in the treaty is not new. But the crowds were larger than at treaty marches before and mood was changed, Indigenous people said.
“It’s different to when I was a child,” Bob said. “We’re stronger now, our tamariki are stronger now, they know who they are, they’re proud of who they are.”
As the marchers moved through the streets of Wellington with ringing Māori haka — rhythmic chants — and waiata, or songs, thousands more holding signs lined the pavement in support.
Some placards bore jokes or insults about the lawmakers responsible for the bill, which would change the meaning of the principles of the 1840 Treaty of Waitangi and prevent them from applying only to Māori — whose chiefs signed the document when New Zealand was colonized.
But others read “proud to be Māori” or acknowledged the bearer’s heritage as a non-Māori person endorsing the protest. Some denounced the widespread expropriation of Māori land during colonization, one of the main grievances arising from the treaty.
“The treaty is a document that lets us be here in Aotearoa so holding it up and respecting it is really important,” said Ben Ogilvie, who is of Pākehā or New Zealand European descent, using the Māori name for the country. “I hate what this government is doing to tear it down.”
Police said more than 35,000 people crowded into Parliament’s grounds, with more spilling into the surrounding streets. People crammed themselves onto the children’s slide on the lawn for a vantage point; others perched in trees. The tone was almost joyful; as people waited to leave the cramped area, some struck up Māori songs that most New Zealanders learn at school.
A sea of Māori sovereignty flags in red, black and white stretched down the lawn and into the streets. But marchers bore Samoan, Tongan, Indigenous Australian, US, Palestinian and Israeli flags, too. At Parliament, speeches from political leaders drew attention to the reason for the protest — a proposed law that would change the meaning of words in the country’s founding treaty, cement them in law and extend them to everyone.
Its author, libertarian lawmaker David Seymour — who is Māori — says the process of redress for decades of Crown breaches of its treaty with Māori has created special treatment for Indigenous people, which he opposes.
The bill’s detractors say it would spell constitutional upheaval, dilute Indigenous rights, and has provoked divisive rhetoric about Māori — who are still disadvantaged on almost every social and economic metric, despite attempts by the courts and lawmakers in recent decades to rectify inequities caused in large part by breaches of the treaty.
It is not expected to ever become law, but Seymour made a political deal that saw it shepherded through a first vote last Thursday. In a statement Tuesday, he said the public could now make submissions on the bill — which he hopes will reverse in popularity and experience a swell of support.
Seymour briefly walked out onto Parliament’s forecourt to observe the protest, although he was not among the lawmakers invited to speak. Some in the crowd booed him.
The protest was “a long time coming,” said Papa Heta, one of the marchers, who said Māori sought acknowledgement and respect.
“We hope that we can unite with our Pākehā friends, Europeans,” he added. “Unfortunately there are those that make decisions that put us in a difficult place.”


Hong Kong jails 45 democracy activists in landmark national security trial

Updated 16 min 10 sec ago
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Hong Kong jails 45 democracy activists in landmark national security trial

  • Activists charged with subversion over unofficial ‘primary election’
  • Organizers had faced up to life in prison under national security laws
  • US criticizes trial as politically motivated, calls for activists’ release

HONG KONG: Hong Kong’s High Court on Tuesday sentenced 45 pro-democracy activists to jail terms of up to 10 years in a landmark national security trial that has damaged the city’s once feisty democracy movement and drawn international condemnation.
A total of 47 pro-democracy activists were arrested and charged in 2021 with conspiracy to commit subversion under a Beijing-imposed national security law and had faced sentences of up to life in prison.
Benny Tai, a former legal scholar identified as an “organizer” of the activists, was sentenced to 10 years in jail, the longest sentence so far under the 2020 national security law.
Some Western governments have criticized the trial, with the US describing it as “politically motivated” and saying the democrats should be released as they had been “peacefully participating in political activities” that were legal.
The Chinese and Hong Kong governments say the national security laws were necessary to restore order after mass pro-democracy protests in 2019, and the democrats have been treated in accordance with local laws.

Closely watched trial
The charges related to the organizing of an unofficial “primary election” in 2020 to select the best candidates for an upcoming legislative election. The activists were accused by prosecutors of plotting to paralyze the government by engaging in potentially disruptive acts had they been elected.
After a 118 day trial, 14 of the democrats were found guilty in May, including Australian citizen Gordon Ng and activist Owen Chow, while two were acquitted. The other 31 pleaded guilty.
Sentences ranged from just over four years to 10 years.
Prominent Hong Kong activist Joshua Wong was sentenced to four years and eight months in jail, while Chow was sentenced to seven years and nine months; former journalist-turned-activist Gwyneth Ho, was sentenced to seven years.
Elsa Wu, the mother of Hendrick Lui, who was sentenced to more than four years in jail, was taken away in a police van outside the courtroom and shouted: “He’s a good person … he’s not a political prisoner … why does he have to go to jail?”
She screamed before police slammed the van door.
Hundreds of people had queued from the early hours outside the court, many holding umbrellas in light rain as they tried to secure a seat within the main courtroom and several spillover courts.
Authorities deployed a tight police presence outside the West Kowloon Magistrates Court and for several blocks in the vicinity.
“I feel such an injustice needs witnessing,” said one woman who gave her name as Margaret and had been in the queue since Sunday afternoon. “I’ve long followed their case. They (the democrats) need to know they still have public support.”
The ruling, which critics have said tarnishes Hong Kong’s role as a global financial hub, comes as the city is hosting an international financial summit to attract more business.
US President-elect Donald Trump’s nominee as secretary of state, Marco Rubio, has been a staunch critic of the trial and in an earlier open letter criticized the convictions of the 47 democrats as evidence of the national security law’s “comprehensive assault on Hong Kong’s autonomy, rule of law, and fundamental freedoms.”
Britain, which handed Hong Kong back to China in 1997, has said the 2020 security law has been used to curb dissent and freedom.


Divided G20 fails to agree on climate, Ukraine

Updated 19 November 2024
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Divided G20 fails to agree on climate, Ukraine

  • In a statement, the G20 called for “comprehensive” ceasefires in both Gaza and Lebanon
  • On Sunday, Biden, who is attempting to ringfence support for Ukraine before Trump’s return to power, gave Kyiv the green light to use long-range US missiles to strike deep inside Russian territory

RIO DE JANEIRO: G20 leaders failed on Monday to break a deadlock in UN climate talks at a summit in Rio that was dominated by divergences over the war in Ukraine and Donald Trump’s impending return to the White House.
Ahead of the meeting, the UN had implored the leaders of the world’s richest economies to rescue stalled climate talks in Azerbaijan by boosting funding for developing countries struggling with global warming.
G20 members, who are divided on who should pay, did not make such commitments, saying only that the trillions of dollars needed would come “from all sources.”
“The leaders are kicking the can back to Baku,” said Mick Sheldrick, co-founder of the advocacy group Global Citizen, referring to the capital of Azerbaijan where the UN climate talks are taking place.
“This is probably going to make it harder to achieve an agreement,” he told AFP.
The risk of an escalation in the war in Ukraine and the prospect of a return of US President-elect Trump’s isolationist “America First” policies also dominated the talks in Brazil.
US President Joe Biden is attending the summit, but as a lame duck eclipsed by China’s Xi Jinping, who has cast himself as a protector of the international order in the new Trump era.
Xi, who held back-to-back meetings with other leaders, warned the world faced a new period of “turbulence” and said there should be “no escalation of wars, and no fanning of flames.”
In a statement, the G20 called for “comprehensive” ceasefires in both Gaza and Lebanon.
The summit was riven with divisions over Ukraine, however.
On Sunday, Biden, who is attempting to ringfence support for Ukraine before Trump’s return to power, gave Kyiv the green light to use long-range US missiles to strike deep inside Russian territory.
Biden’s move — a major policy shift by the US — threatens to escalate a war Trump has vowed to quickly end.
Russia on Monday warned of an “appropriate response” if its territory was hit.
German Chancellor Olaf Scholz said he would not follow Biden’s lead with his country’s Taurus missiles, but French President Emmanuel Macron praised a “good” move by Biden.

Brazilian President Luiz Inacio Lula da Silva attempted to put issues close to his heart, such as fighting hunger and climate change, at the top of the agenda.
At the opening of the summit, he launched the centerpiece of his G20 presidency: a Global Alliance against Poverty and Hunger backed by 82 countries that aims to feed half a billion people by 2030.
He won further praise from campaigners by garnering support for a bid to make billionaires pay more tax.
The summit statement included a pledge to “engage cooperatively to ensure that ultra-high-net-worth individuals are effectively taxed,” and to devise mechanisms to prevent them dodging tax authorities.
“Brazil has lit a path toward a more just and resilient world, challenging others to meet them at this critical juncture,” anti-poverty group Oxfam said in a statement.
But Lula’s progressive social agenda met some resistance from Argentina’s libertarian president Javier Milei, an ardent fan of Trump and his billionaire adviser Elon Musk.
Milei said he opposed points in the summit declaration, including increasing state intervention to combat hunger and regulating social media but saved Brazil’s blushes by nonetheless signing up to the joint statement.
The meeting comes in a year marked by another grim litany of extreme weather events, including Brazil’s worst wildfire season in over a decade, and the opening of a new front in Israel’s wars with its Arab neighbors.
“Today the world is on a knife edge,” EU Council President Charles Michel warned.
The get-together caps a diplomatic farewell tour by Biden that took him to Lima for a meeting of Asia-Pacific trading partners, and then to the Amazon in the first such visit for a sitting US president.
Conspicuously absent from the summit was Russian President Vladimir Putin, whose arrest is sought by the International Criminal Court over the Ukraine war.
 

 


Hong Kong to sentence dozens of democracy campaigners

Updated 19 November 2024
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Hong Kong to sentence dozens of democracy campaigners

  • The sentencing is “a very important indicator to show the general public (the degree of) openness and inclusivity in our society,” Lee Yue-shun, one of those acquitted, told AFP on Tuesday as he waited outside court

HONG KONG: Hong Kong’s largest national security trial will draw to a close on Tuesday, with dozens of the city’s most prominent democracy campaigners set to be sentenced for subversion, a charge that can carry up to life imprisonment.
Beijing imposed a sweeping national security law on the financial hub in 2020, snuffing out months of massive, sometimes violent, pro-democracy protests.
Western countries and international rights groups have condemned the trial as evidence of Hong Kong’s increased authoritarianism.
The “Hong Kong 47” were arrested in 2021 after holding an unofficial election primary that aimed to improve pro-democracy parties’ chances of winning a majority in the city’s legislature.
Two of the 47 were acquitted in May, but on Tuesday, the rest will learn their sentences, many after more than 1,300 days in jail.
The sentencing is “a very important indicator to show the general public (the degree of) openness and inclusivity in our society,” Lee Yue-shun, one of those acquitted, told AFP on Tuesday as he waited outside court.
A friend of defendant Gordon Ng, named by prosecutors as one of five organizers, told AFP she had been suffering insomnia in the past few days.
“Gordon seemed nervous too,” the woman said about her visit to Ng in prison. “But... he kept telling us not to overthink.”
This case is the largest by number of defendants since the law was passed in mid-2020.
Another major national security trial will see a key development on Wednesday, when jailed pro-democracy media tycoon Jimmy Lai testifies in his collusion trial.
The charges against Lai revolve around publications in his now-shuttered tabloid Apple Daily, which supported the pro-democracy protests and criticized Beijing’s leadership.
China and Hong Kong say the security law restored order following the 2019 protests, and have warned against “interference” from other countries.

At dawn on Tuesday, more than 200 people stood in the chilly drizzle outside the court where the sentencing will take place.
Some had been queuing since Saturday to nab a public seat.
Eric, an IT professional based in mainland China, spent a day of holiday waiting in line.
“I want to bear witness of how Hong Kong becomes mainland China,” Eric told AFP.
“In the future, cases like this may not be open to the public anymore.”
Jack, a law student, said he wanted to witness the sentencing because he found the judgment “was not particularly convincing.”
He said he was pessimistic that the sentencing would be lenient, but that even if it was, “people’s passion for political participation has dissipated in the face of restrictions.”
The aim of the election primary, which took place in July 2020, was to pick a cross-party shortlist of pro-democracy candidates to increase their electoral prospects.
If a majority was achieved, the plan was to force the government to meet the 2019 protesters’ demands — including universal suffrage — by threatening to indiscriminately veto the budget.
Three senior judges handpicked by the government to try security cases said the group would have caused a “constitutional crisis.”

The “principal offenders” face 10 years to life in jail.
Legal scholar Benny Tai has been named “the brain behind the project” by prosecutors.
Others singled out as “more radical” are the ex-leaders of the now-disbanded Civic Party Alvin Yeung and Jeremy Tam, young activist Owen Chow and former journalist Gwyneth Ho.
The oldest defendant is “Long Hair” Leung Kwok-hung, the 68-year-old co-founder of the city’s last standing opposition party the League of Social Democrats.
His wife Chan Po-ying, the leader of the LSD, told AFP that Leung “does not have any special thoughts on the sentence” after visiting him on Monday.
“I feel rather calm too... I wish for no surprise and no shock,” Chan said.
Emilia Wong, girlfriend of rally organizer Ventus Lau, said Lau appeared more anxious in recent months.
They hadn’t discussed the potential sentence much because “it’s an unprecedented case,” she said.
“A long time ago, he said if the sentence is up to 10 years or 20 years, I should not wait for his release,” Wong told AFP.
“The (sentencing) day may be a significant milestone for the outside world but for me... I will just have to carry on with my normal life, visiting him and handling his matters.”