UK, US COVID-19 vaccines show signs of immunity in patients

The trials, run by teams at Oxford University in the UK and pharmaceutical company Moderna in the US, have both received significant government funding in their bids to develop their vaccines before the end of the year. (AFP)
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Updated 15 July 2020
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UK, US COVID-19 vaccines show signs of immunity in patients

  • Dr. Anthony Fauci: ‘No matter how you slice this, this is good news’

LONDON: Two of the world’s most promising studies to develop a vaccine for COVID-19 have said subjects in their trials have shown early signs of immunity. 

The trials, run by teams at Oxford University in the UK and pharmaceutical company Moderna in the US, have both received significant government funding in their bids to develop their vaccines before the end of the year.

The Oxford vaccine, being manufactured by AstraZeneca, based in Cambridge, England, has already had millions of doses mass-produced in the event of the trials proving a success. The team behind it says it is “80 percent confident” of it being available by September. 

It works by injecting altered COVID-19 genetic material, attached to a similar but benign virus called an adenovirus, which causes common colds, into the body, in a process known as recombinant viral vector vaccination. 

The aim is to facilitate an immune system response by mimicking COVID-19 itself, and training antibodies to attack the spike proteins on the virus’s exterior that it uses to attach itself to human cells.

When faced with COVID-19, in theory the immune system should then act in the same fashion.

The Oxford vaccine is currently in its second, expanded trial stage, featuring 8,000 people in the UK and up to 6,000 people in Brazil and South Africa.

Though no official results have been formally published, subjects exposed to the vaccine in its early phase were found to have developed antibodies and a certain type of white blood cell, called T-cells, which help fight infection

“An important point to keep in mind is that there are two dimensions to the immune response: Antibodies and T-cells,” a source at Oxford told ITV News in the UK.

“Everybody is focused on antibodies, but there is a growing body of evidence suggesting that the T-cells response is important in the defense against coronavirus.”

Prof. Sarah Gilbert, the Oxford team leader, earlier this month said the vaccine could provide protection for several years at a time.

She told UK MPs on the House of Commons’ science and technology select committee: “Vaccines have a different way of engaging with the immune system, and we follow people in our studies using the same type of technology to make the vaccines for several years, and we still see strong immune responses.”

She added: “It’s something we have to test and follow over time — we can’t know until we actually have the data, but we’re optimistic based on earlier studies that we’ll see a good duration of immunity, for several years at least, and probably better than naturally acquired immunity.”

Moderna, meanwhile, reported that all 45 volunteers in its early phase had developed immune responses after receiving its vaccine, though with more than half its subjects experiencing mild or moderate side effects including headaches, fatigue and muscle pain.

Its vaccine, called mRNA-1273, uses ribonucleic acid to program human cells to make proteins similar to the spike proteins of COVID-19 cells, training the body’s immune system to identify and attack them.

Its initial studies found that higher doses of mRNA-1273 in the human system corresponded with higher levels of immunity in subjects, by injecting people with doses of 25, 100 or 250 micrograms of the vaccine in two instalments over 28 days.

Moderna will begin a second trial of 30,000 people later this month. The US government has so far pledged nearly half a billion dollars in funding for the Moderna vaccine.

The director of the US National Institute of Allergy and Infectious Diseases, Dr. Anthony Fauci, said: “No matter how you slice this, this is good news.”

Vaccines, though, are not the only potential route in the quest to find a solution to the COVID-19 pandemic.

Trials have already begun for an antibody treatment, manufactured by AstraZeneca, that would see patients given a three-minute infusion of COVID-19 antibodies that could provide protection for up to six months.

This would be a potential solution if the vaccine proves less effective in some people (especially the elderly), for those who suffer adverse reactions, or for people taking immunosuppressant drugs or undergoing chemotherapy.

Sir Mene Pangalos, head AstraZeneca’s research into respiratory diseases, said: “There’s a population who are elderly that (may not) get a particularly good immune response to the vaccine.

“In those instances you might want to prophylactically treat those patients with an antibody to give them additional protection.”


’Deaths’ during mass prison break in DR Congo’s Goma: security source

Updated 6 sec ago
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’Deaths’ during mass prison break in DR Congo’s Goma: security source

GOMA: A mass jailbreak was taking place on Monday morning at a prison in the besieged Congolese city of Goma, hours after fighters from the armed group M23 and Rwandan troops entered the city, a security source told AFP.
The prison, which holds around 3,000 inmates, was “totally torched” following a huge jailbreak that resulted in “deaths,” the security source said, without giving further details.
Fleeing prisoners could be seen in the surrounding streets, according to an AFP journalist.

Bird feathers and bloodstains found in Jeju jet engines: South Korea report

Updated 53 min 10 sec ago
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Bird feathers and bloodstains found in Jeju jet engines: South Korea report

  • The Boeing 737-800 was flying from Thailand to Muan in South Korea on Dec. 29 when it crash landed
  • It was the worst aviation disaster on South Korean soil, killing 179 of the 181 passengers and crew

SEOUL: Bird feathers and bloodstains were found in both engines of the Jeju Air plane that crashed in December, according to a preliminary investigation released Monday.
The Boeing 737-800 was flying from Thailand to Muan in South Korea on December 29 when it crash landed and exploded into a fireball after slamming into a concrete barrier.
It was the worst aviation disaster on South Korean soil, killing 179 of the 181 passengers and crew.
South Korean and American investigators are still probing the cause of the disaster, with a bird strike, faulty landing gear and the runway barrier among the possible issues.
Both engines recovered from the crash site were inspected, and bird bloodstains and feathers were “found on each,” the report said.
“The pilots identified a group of birds while approaching runway 01, and a security camera filmed HL8088 coming close to a group of birds during a go-around,” the report added, referring to the Jeju jet’s registration number.
It did not specify whether the engines had stopped working in the moments leading up to the crash.
DNA analysis identified the feathers and blood as coming from Baikal teals, migratory ducks which fly to Korea in winter from their breeding grounds in Siberia.
After the air traffic control tower cleared the jet to land, it advised the pilots to exercise caution against potential bird strikes at 8:58 am, the report said. Just a minute later, both the voice and data recording systems stopped functioning.
Seconds after the recording systems failed, the pilots declared mayday due to a bird strike and attempted a belly landing.
The Jeju plane exploded in flames when it collided with a concrete embankment during its landing, prompting questions about why that type barricade was in place at the end of the runway.
Last week, authorities said they would replace such concrete barriers at airports nationwide with “breakable structures.”
The captain had over 6,800 flight hours, while the first officer had 1,650 hours, according to the report. Both were killed in the crash, which was survived only by two flight attendants.


Lukashenko pockets massive win in Belarus election scorned by the West

Updated 27 January 2025
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Lukashenko pockets massive win in Belarus election scorned by the West

  • Alexander Lukashenko took 86.8 percent of the vote in Sunday’s election
  • European politicians have said the vote was neither free nor fair

MELBOURNE: Belarusian leader Alexander Lukashenko extended his 31-year rule with a massive win in a presidential election that Western governments have rejected as a sham, according to preliminary results on Monday.
“You can congratulate the Republic of Belarus, we have elected a president,” the head of the country’s Central Election Commission of the Republic Igor Karpenko told a press conference in the early hours of Monday, according to Russian state media.
According to results published on the Central Election Commission’s Telegram account, Lukashenko took 86.8 percent of the vote in Sunday’s election.
European politicians said the vote was neither free nor fair because independent media are banned in the former Soviet state and all leading opposition figures have been sent to penal colonies or forced to flee abroad.
“The people of Belarus had no choice. It is a bitter day for all those who long for freedom & democracy,” German Foreign Minister Annalena Baerbock posted on X.
Polish Foreign Minister Radoslaw Sikorski expressed mock surprise that “only” 87.6 percent of the electorate appeared to have backed Lukashenko.
“Will the rest fit inside the prisons?” he wrote on X.
Asked about the jailing of his opponents, Lukashenko said they had “chosen” their fate.
“Some chose prison, some chose ‘exile’, as you say. We didn’t kick anyone out of the country,” he told a rambling press conference on Sunday that lasted more than four hours and 20 minutes.
The close ally of Russian President Vladimir Putin had earlier defended his jailing of dissidents and declared: “I don’t give a damn about the West.”


UN Security Council demands pullout of Rwanda-backed armed group from DR Congo

Updated 27 January 2025
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UN Security Council demands pullout of Rwanda-backed armed group from DR Congo

  • UN Security Council condemns ‘flagrant disregard’ for sovereignty in DR Congo
  • Congo late Saturday broke off relations with Rwanda, which has denied backing the M23 despite evidence collected by UN experts and others
  • US, France tells Rwanda to back off, warning that the US would hold accountable those responsible for sustaining the armed conflict

UNITED NATIONS/GOMA, Congo: The UN Security Council on Sunday denounced the “flagrant disregard” for the sovereignty and territorial integrity of the Democratic Republic of Congo (DRC), demanding the withdrawal of “external forces” without explicitly naming them.
The Council “condemned the ongoing flagrant disregard for the sovereignty and territorial integrity of the DRC, including the unauthorized presence in the Eastern DRC of external forces as reported by the Group of Experts and demanded that these forces withdraw immediately,” it said in a statement Sunday evening, referencing a UN expert report that criticized the presence of Rwandan forces and their support for the M23 armed group fighting the Congolese army.
During an emergency meeting of the Security Council, UN‘s special representative for Congo said the attacking forces has caused “mass panic” in eastern Congo’s largest city, Goma, a humanitarian and security hub and home to 2 million people.

“M23 has declared the airspace over Goma closed,” UN special representative, Bintou Keita said. “In other words, we are trapped.” 

Internally displaced civilians from the camps in Munigi and Kibati, carry their belongings as they flee following the fight between M23 rebels and DR Congo forces in Goma on January 26, 2025. (REUTERS)

Keita said M23 fighters were using residents “as human shields” as they advanced, while others fled for their lives.

The M23 rebels’ offensive at the heart of the mineral-rich region threatens to dramatically worsen one of Africa’s longest wars and create further misery for what is already one of the world’s largest humanitarian crises, with millions of people displaced.

‘Declaration of war’

Congo late Saturday broke off relations with Rwanda, which has denied backing the M23 despite evidence collected by UN experts and others. Congo’s government called it a “declaration of war.”

The surge of violence has killed at least 13 peacekeepers over the past week. And Congolese were again on the run.

The M23 has made significant territorial gains along Congo’s border with Rwanda in recent weeks, after months of regional attempts to make peace failed. On Sunday night, the rebels called on Congo’s army to surrender their arms and present themselves at a local stadium by 3 a.m. or they would take the city.

The Uruguayan army, who are in Goma serving with the UN peacekeeping mission, said in a statement on X late Sunday that some Congolese soldiers have laid down their weapons.

“More than a hundred FARDC soldiers are sheltered in the facilities of the “Siempre Presente” base awaiting the (Disarmament, Demobilization and Reintegration) process,” the statement said.

In photos shared with the statement, armed men are seen registering with the peacekeepers in a mix of military uniforms and civilian clothing.
Congo’s foreign minister, Thérèse Kayikwamba Wagner, told the Security Council that Rwanda was committing “a frontal aggression, a declaration of war which no longer hides itself behind diplomatic maneuvers.”
Rwanda’s ambassador to the UN, Ernest Rwamucyo, did not confirm or deny Congo’s claims. He blamed Congo’s government, saying the crisis could have been been averted if it had “demonstrated a genuine commitment to peace.”

US and France weigh in

The United States and France called for a ceasefire and appealed to Rwanda to withdraw its support to M23, with acting US Ambassador Dorothy Shea warning that the US would “consider all the tools at its disposal” to hold accountable those responsible for sustaining the armed conflict.
In the past 48 hours, two UN peacekeepers from South Africa and one from Uruguay were killed and 11 others were injured and hospitalized, UN Secretary-General Antonio Guterres’ spokesman said ahead of the Security Council meeting.
The UN chief reiterated his “strongest condemnation” of the M23 offensive “with the support of the Rwanda Defense Forces,” and called on the rebel group to immediately halt all hostile action and withdraw, spokesman Stephane Dujarric said.
Congo, the United States and UN experts accuse Rwanda of backing M23, which is mainly made up of ethnic Tutsis who broke away from the Congolese army more than a decade ago. It’s one of about 100 armed groups that have been vying for a foothold in the mineral-rich region, where a long-running conflict has created one of the world’s largest humanitarian crises.

 

Rwanda’s government denies backing the rebels, but last year acknowledged that it has troops and missile systems in eastern Congo to safeguard its security, pointing to a buildup of Congolese forces near the border. UN experts estimate up to 4,000 Rwandan forces are in Congo.
Congo’s foreign ministry said late Saturday it was severing diplomatic ties with Rwanda and pulling all diplomatic staff from the country “with immediate effect.”
Rwandan Foreign Minister Olivier Nduhungirehe told The Associated Press on Sunday that the decision to cut ties was a unilateral move by Congo.
“For us, we took appropriate measures to evacuate our remaining diplomat in Kinshasa, who was under permanent threat by Congolese officials,” Nduhungirehe said.
The M23 took Goma once before in 2012, withdrawing after considerable international pressure was put on Rwanda.

 

Civilians flee the rebel advance
On Sunday morning, heavy gunfire resonated across Goma, a few kilometers (miles) from the front line. Scores of children and adults fled the Kanyaruchinya camp, one of the largest in eastern Congo for displaced people, near the Rwandan border.
“We are fleeing because we saw soldiers on the border with Rwanda throwing bombs and shooting,” said Safi Shangwe, who was heading into the city.
Some of the displaced worried they would not be safe in Goma, either. “I heard that there are bombs in Goma, too, so now we don’t know where to go,” said Adèle Shimiye.
Hundreds of people attempted to flee to Rwanda. Migration officers at a border crossing east of Goma carefully checked travel documents.
“I am crossing to the other side to see if we will have a place of refuge because for the moment, security in the city is not guaranteed,” Goma resident Muahadi Amani told the AP.
UN deputy humanitarian chief Joyce Msuya said the situation was rapidly deteriorating. “If hostilities spill into Goma – a densely populated urban center – the impact on civilians could be devastating,” she said.
Congo’s army has said it was fending off the M23 offensive with the help of allied forces, including UN peacekeepers and soldiers from the Southern African Development Community Mission, also known as SAMIDRC.
In addition to the two South African peacekeepers, seven South African troops with SAMIDIRC have been killed in recent days, South Africa’s defense ministry said.
Since 2021, Congo’s government and allied forces — including the 14,000-strong UN mission — have been keeping M23 away from Goma.
Goma resident Bahati Jackson’s family has been hearing gunfire and remembers fleeing M23’s seizure of the city in 2012. But this time, they’re staying.
“If we’re going to die, it’s better to die here,” Jackson said.
 


Elon Musk says $1 million election giveaway wasn’t an illegal lottery

Updated 27 January 2025
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Elon Musk says $1 million election giveaway wasn’t an illegal lottery

  • Arizona resident Jacqueline McAferty claimed that Musk and his political action committee America PAC falsely induced voters in seven battleground states to sign the petition by promising that winners would be chosen randomly

WASHINGTON: Elon Musk asked a federal judge to dismiss a proposed class action by voters who said the world’s richest person defrauded them into signing a petition to support the US Constitution for a chance to win his $1 million-a-day giveaway.
In a late Friday filing in the Austin, Texas federal court, Musk rejected the claim the giveaway was an illegal “lottery” that violated a Texas law against deceptive trade practices.
Arizona resident Jacqueline McAferty claimed that Musk and his political action committee America PAC falsely induced voters in seven battleground states to sign the petition by promising that winners would be chosen randomly.
Musk founded America PAC to support Republican Donald Trump’s successful 2024 presidential run.
According to Musk, however, voters were told they would be reviewed for an opportunity to earn the $1 million by becoming America PAC spokespeople.
This, Musk said, defeated any notion that the money was a “prize” to be won.
“Make no mistake: an eligible voter’s opportunity to earn is not the same thing as a chance to win,” Musk said.
Chance, he added, “was not involved here.”
Musk also rejected the suggestion that petition signers suffered harm by providing their names, addresses and phone numbers, which they said Musk and America PAC could then sell.
Lawyers for the proposed class did not immediately respond to requests for comment on Sunday.
The lawsuit was filed on Election Day, Nov. 5, 2024.
A day earlier, a Philadelphia judge refused to end Musk’s giveaway, saying that city’s top prosecutor also failed to show it was an illegal lottery.
McAferty’s lawsuit seeks at least $5 million in damages for everyone who signed the petition.
Musk is a Texas resident and his electric car company Tesla is based in Austin.
The case is McAferty v Musk et al, US District Court, Western District of Texas, No. 24-01346.