Arthritis drug trialled as potential treatment for COVID-19

The first patient, administered with the drug, is currently being cared for at Manchester Royal Infirmary (MRI), part of Manchester University NHS Foundation Trust (MFT). (Courtesy MFT)
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Updated 28 September 2020
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Arthritis drug trialled as potential treatment for COVID-19

  • Dr. Andy Martin: We are conducting this study to see whether otilimab could potentially ease the effect of COVID- 19 on the lungs
  • Dr. Tim Felton: The primary end point of this study is that participants are alive and free of lung failure after 28 days — so this research is potentially life-saving

LONDON: The experimental arthritis drug, otilimab, is being trialled as a potential treatment for COVID-19.

The first patient administered with the drug is currently being cared for at Manchester Royal Infirmary (MRI), part of Manchester University NHS Foundation Trust (MFT).

The OSCAR study (Otilimab in Severe COVID-19 Related Disease) is sponsored and funded by the pharmaceutical company GlaxoSmithKline.

The study at the MRI is being led by Dr. Andy Martin, an Intensive Care and Anaesthesia Consultant.

Dr. Martin said: “The patients eligible to take part in this study are those experiencing very severe lung difficulties due to COVID-19 infection and are receiving oxygen or ventilator support.

“We are conducting this study to see whether otilimab — which is under investigation as a potential treatment for rheumatoid arthritis — could also potentially ease the effect of coronavirus on the lungs, dampening the impact of the virus on the immune system.

Christopher Corsico, GSK's Senior Vice President Development, said: “We are continuing to work hard to find solutions to address the pandemic, including exploring potential treatment options for COVID-19 patients.

“We know that some COVID-19 patients experience an overreaction of their immune system — sometimes referred to as cytokine storm — which can lead to hospitalization or death. We believe that otilimab might be able to help counter or calm this process.

Dr. Tim Felton, honorary consultant, senior lecturer at The University of Manchester and Clinical Lead for all MFT COVID-19-related research studies, leads OSCAR at Wythenshawe Hospital, which is also part of MFT.

Dr. Felton said: “The primary end point of this study is that participants are alive and free of lung failure after 28 days — so this research is potentially life-saving.

“I’d like to thank our first OSCAR participant — as well as the thousands of others who have taken part in coronavirus studies at MFT to date — as every participant who takes part in our research is contributing to the coordinated effort to enhance understanding of this global pandemic.”


Trump drives his anti-immigration message in Aurora, Colorado

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Trump drives his anti-immigration message in Aurora, Colorado

  • Calls for death penalty for any migrant that kills an American citizen or a law enforcement officer
  • Ignores rejection by Aurora officials of Venezuelan gang takeover

 

AURORA, Colorado: Donald Trump detoured from the battleground states Friday to visit a Colorado suburb that’s been in the news over illegal immigration as he drives a message, often using false or misleading claims and dehumanizing language, that migrants are causing chaos in smaller American cities and towns.
Trump’s rally in Aurora marked the first time ahead of the November election that either presidential campaign has visited Colorado, which reliably votes Democratic statewide.
The Republican nominee has long promised to stage the largest deportation operation in US history and has made immigration core to his political persona since launching his first campaign in 2015. In recent months, Trump has pinpointed specific smaller communities that have seen large arrivals of migrants, with tensions flaring locally over resources and some longtime residents expressing distrust about sudden demographic changes.
Aurora entered the spotlight in August when a video circulated showing armed men walking through an apartment building housing Venezuelan migrants. Trump has claimed extensively that Venezuelan gangs are taking over buildings, even though authorities say that was a single block of the suburb near Denver, and the area is again safe.
Ignoring those denials from local authorities, Trump painted a picture of apartment complexes overrun by “barbaric thugs” and streets unsafe to travel, blaming President Joe Biden and Vice President Kamala Harris, Trump’s Democratic rival.
“They’re ruining your state,” Trump said of the Democrats in the White House.
“No person who has inflicted the violence and terror that Kamala Harris has inflicted on this community can ever be allowed to become the president of the United States,” Trump added.

Dehumanizing language

Trump often used dehumanizing language, referring to his political rivals as “scum” and to migrants as ” animals ” who have “invaded and conquered” Aurora. The town is “infected by Venezuela,” he said.
“We have to clean out our country,” Trump said. And he reprised the first controversy of his career in politics, when he launched his 2016 campaign by saying migrants are rapists and bring drugs and crime.
“I took a lot of heat for saying it, but I was right,” Trump said Friday, repeating the false claim that other countries are emptying their prisons and mental institutions and dumping their worst criminals in the United States.
To thunderous applause, he called for the death penalty “for any migrant that kills an American citizen or a law enforcement officer.”
Trump announced that as president he’d launch “Operation Aurora” to focus on deporting members of the Venezuelan gang Tren de Aragua, or TDA. The violent gang traces its origins more than a decade to an infamously lawless prison with hardened criminals.
Trump also repeated his pledge to invoke the Alien Enemies Act, a 1798 law that allows the president to deport any noncitizen who is from a country that the US is at war with.
In July, the Biden administration issued a sanction against the gang and offered $12 million in rewards for the arrest of three leaders.

Trump exagerrates

Aurora resident Jodie Powell, 54, was among the attendees at Trump’s Friday event. She said it’s “not the case” that Venezuelan gangs have taken over the city, as Trump claims. Still, Powell said she’s seen an increase in crime she associates with newcomers, citing a police chase that ended at a store where she was shopping.
“It takes a small amount of people to make a big difference in the community,” said Powell, who ranks immigration as her top concern alongside the economy. “It’s scary, it’s a scary thing.”
At the venue where Trump appeared, posters displayed mug shots of people in prison-orange with descriptions including “Illegal immigrant gang members from Venezuela.”
“Look at all these photos around me,” Stephen Miller, a former top aide who is expected to take a senior role in the White House if Trump wins, told the crowd. “Are these the kids you grew up with? Are these the neighbors you were raised with? Are these the neighbors that you want in your city?” The crowd roared ”no” in reply.
Some Colorado officials, including the Republican mayor of Aurora, accused Trump and other Republicans of overstating problems in the city.
“Again, the reality is that the concerns about Venezuelan gang activity in our city — and our state — have been grossly exaggerated and have unfairly hurt the city’s identity and sense of safety,” said Mike Coffman, a former US congressman.

Spreading falsehoods

Trump and his running mate, Ohio Sen. JD Vance, also have spread falsehoods about a community in Springfield, Ohio, where they said Haitian immigrants were accused of stealing and eating pets.
While Ohio and Colorado are not competitive in the presidential race, the Republican message on immigration is intended for states that are. Vance campaigned recently in Eau Claire, Wisconsin, a city of 70,000 that has resettled refugees from Africa and Asia, and touted Trump’s plan to ramp up deportations. He argues smaller communities have been “overrun” by immigrants taxing local resources.
Trump has vowed to deport not only “criminals,” a promise he shares with Harris, but also Haitians living legally in Springfield and even people he has denigrated as “pro-Hamas radicals” protesting on college campuses. Trump has said he would revoke the temporary protected status that allows Haitians to stay in the US because of widespread poverty and violence in their home nation.
Harris has tacked to the right on immigration, presenting herself as a candidate who can be tough on policing the border, which is perceived as one of her biggest vulnerabilities.
She wrapped up a three-day western swing with a campaign event Friday in Scottsdale, Arizona, where she said she would create a bipartisan council of advisers to provide feedback on her policy initiatives if she makes it to the White House.
“I love good ideas wherever they come from,” said Harris, who is making a push to get Republicans with doubts about Trump to support her.

Trump let Iran off the hook: Harris

She also accused Trump of letting Iran “off the hook” while he was in office and argued she would be a greater champion for Israel’s security.
“Make no mistake, as president, I will never hesitate to take whatever action is necessary to defend American forces and interests from Iran and Iran-backed terrorists,” Harris said in a call with Jewish supporters ahead of Yom Kippur. “And I will never allow Iran to acquire a nuclear weapon. Diplomacy is my preferred path to that end. But all options are on the table.”
Harris charged that Trump “did nothing” after Iran “attacked US bases and American troops.”
The criticism by Harris was a knock on Trump for downplaying a January 2020 missile attack by Iran on a US base in Iraq that left several American troops with concussion-like symptoms, including some who had to be evacuated for treatment. Trump earlier this month referred to the injuries as a “headache.”
The Iranian missile attack came days after Trump ordered a strike that that killed Qassem Soleimani, the head of Iran’s elite Quds Force, and raised tensions between the US and Iran.
Harris participated virtually in a White House briefing with President Biden on the recovery effort from hurricanes Milton and Helene. She sought to reassure those who endured losses from the hurricane that they would get help from the government.


Fourteen years in prison for US soldier who sought to aid Daesh

Cole Bridges. (Social media)
Updated 12 October 2024
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Fourteen years in prison for US soldier who sought to aid Daesh

  • According to court documents, Bridges, who joined the army in 2019, went from consuming online terrorist propaganda to trying to provide information to aid Daesh, which once held swathes of Iraq and Syria

WASHINGTON: A US soldier who pleaded guilty to trying to provide information to the Daesh group to help it attack American troops in the Middle East was sentenced to 14 years in prison on Friday.
Cole Bridges, 24, pleaded guilty in June of last year to attempting to provide material support to a designated foreign terrorist organization and attempting to murder US military service members.
Bridges, a private first class from Ohio, was sentenced to 14 years in prison on Friday and 10 years of supervised release, the Justice Department said in a statement.
According to court documents, Bridges, who joined the army in 2019, went from consuming online terrorist propaganda to trying to provide information to aid Daesh, which once held swathes of Iraq and Syria.
In October 2020, Bridges began communicating with an FBI employee who was posing as an Daesh supporter, the Justice Department said.
“During these communications, Bridges expressed his frustration with the US military and his desire to aid Daesh,” the department said.
Bridges provided “training and guidance” to purported Daesh fighters, including advice about potential targets in New York City, it said, and information on “how to attack US forces in the Middle East.”
In January 2021, Bridges, who was based at Fort Stewart in Georgia, sent a video to the covert FBI employee of himself in body armor standing in front of a flag used by Daesh fighters.
 

 


Russia’s Putin cements ties with Iranian president in Central Asia meeting

Updated 12 October 2024
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Russia’s Putin cements ties with Iranian president in Central Asia meeting

  • Putin invites Pezeshkian to Russia for official visit
  • US concerned over closer Iran-Russia ties

MOSCOW: Russia’s Vladimir Putin held talks with Iranian President Masoud Pezeshkian on Friday in Turkmenistan, where the two leaders hailed their countries growing economic ties and similar views on world affairs, an entente viewed with concern by the United States.
At odds with Washington and the European Union over Russia’s war in Ukraine, something he casts as part of a wider existential struggle against an arrogant and self-interested West — Putin is keen to deepen ties with what he calls the Global East and Global South.
Putin, whose country is hosting a summit of the BRICS nations in Kazan on Oct. 22-24, invited Pezeshkian to come to Russia on an official visit, a proposal the Iranian leader accepted according to Russia’s state RIA news agency.
“Economically and culturally, our communications are being strengthened day by day and becoming more robust,” Pezeshkian was cited as telling Putin by Iran’s official IRNA news agency.
“The growing trend of cooperation between Iran and Russia, considering the will of the top leaders of both countries, must be accelerated to strengthen these ties,” he said.
In a later report from Dubai, Russia’s TASS news agency quoted the Iranian president, in a video issued by his office, as saying the two sides had agreed to boost cooperation in a number of areas.
“Our talks with the Russian president lasted about an hour. And we talked again about agreements that we have concluded,” the report quoted him as saying.
“We have constructive interaction. We agreed to speed up the completion of projects in the gas sectors, in road and rail construction, desalination and other projects linked to energy, petrochemicals and electricity.”
Pezeshkian last month committed his country to deeper ties with Russia to counter Western sanctions. The two countries say they are close to signing a strategic partnership agreement, something Pezeshkian said on Friday he hoped could be finalized at the BRICS summit in Russia later this month.
The United States regards Moscow’s growing relationship with Tehran with concern. It has accused Iran of supplying Russia with ballistic missiles for use in the conflict in Ukraine, something Tehran has denied.
Russia says cooperation with Iran is expanding in all areas.
“We actively work together in the international arena, and our assessments of current events in the world are often very close,” TASS cited Putin as telling Pezeshkian on the sidelines of the conference in the Turkmen capital of Ashgabat.
Pezeshkian, according to IRNA, noted that Iran and Russia had significant complementary capacities and could assist each other. “Our positions in the world are much closer to each other than to others,” he was quoted as telling the Russian leader.
Pezeshkian said earlier that Israel should “stop killing innocent people,” and its actions in the Middle East were backed by the US and EU. Russia has also criticized Israel, which says it is protecting its own security, for bombing civilian areas.
Putin was cited by TASS as telling Pezeshkian that economic ties between Moscow and Tehran were on the up.
In comments released by the Kremlin earlier on Friday, Putin told the conference in the Central Asian country that a new world order was being formed and that new centers of economic growth and financial and political influence were emerging.
Russia supported “the broadest possible international discussion” on the emerging multipolar world and was open to discussing it within various fora, including the Commonwealth of Independent States, the Eurasian Economic Union, the Shanghai Cooperation Organization, and BRICS, said Putin.


US expands sanctions on Iran in response to its ballistic attack on Israel

Updated 12 October 2024
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US expands sanctions on Iran in response to its ballistic attack on Israel

  • Increasingly, however, escalating attacks between Israel and Iran and its Arab allies threaten to push the Middle East closer to a regional war

WASHINGTON: The US on Friday announced new sanctions on Iran’s energy sector in response to its Oct. 1 attack on Israel when it fired roughly 180 missiles into the country.
Iran said the barrage was retaliation for a series of devastating blows Israel has landed in recent weeks against the Iran-backed militant group Hezbollah in Lebanon, which has been firing rockets into Israel since the war in Gaza began.
Included in Friday’s sanctions are blocks on Iran’s so-called “ghost fleet” of ships and associated firms that span the United Arab Emirates, Liberia, Hong Kong and other jurisdictions that allegedly obfuscate and transport Iranian oil for sale to buyers in Asia.
Additionally, the US State Department designated a network of companies based in Suriname, India, Malaysia and Hong Kong for allegedly arranging for the sale and transport of petroleum and petroleum products from Iran.
Current US law authorizes sanctions targeting Iran’s energy sector as well as foreign firms that buy sell and transport Iranian oil. But energy sanctions are often a delicate issue as restricting supplies could push up prices for global commodities that the US and its allies need.
Jake Sullivan, the US national security advise, said the new sanctions “will help further deny Iran financial resources used to support its missile programs and provide support for terrorist groups that threaten the United States, its allies, and partners.”
The penalties aim to block them from using the US financial system and bar American citizens from dealing with them.
Israel and Iran have fought a shadow war for years, but rarely have they come into direct conflict. Increasingly, however, escalating attacks between Israel and Iran and its Arab allies threaten to push the Middle East closer to a regional war.
Iran launched another direct attack on Israel in April, but few of its projectiles reached their targets. Many were shot down by a US-led coalition while others apparently failed at launch or crashed in flight.
Treasury Secretary Janet Yellen said Friday that the United States “will not hesitate to take further action to hold Iran accountable.”

 


Scholz, Erdogan to discuss Middle East conflict in Istanbul

German Chancellor Olaf Scholz. (REUTERS)
Updated 11 October 2024
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Scholz, Erdogan to discuss Middle East conflict in Istanbul

  • Migration and economic policy issues will be on the agenda, German official says

BERLIN: Chancellor Olaf Scholz will visit Turkiye next week to meet President Recep Tayyip Erdogan with the escalating conflict in the Middle East and migration on the agenda, German officials said Friday.

Scholz will hold talks with Erdogan on Oct.19 in Istanbul, followed by a press conference, government spokesman Wolfgang Buechner told a media briefing in Berlin.
The German chancellor last visited Turkiye in March 2022, a few months after taking office.
“The war in Ukraine will be the subject of the talks, as will the situation in the Middle East. Migration and bilateral and economic policy issues will also be on the agenda,” Buechner said.

FASTFACT

Germany is home to Europe’s largest Turkish diaspora of some 3 million people.

Germany’s relations are sensitive with Turkiye, a fellow NATO member.
Germany is home to Europe’s largest Turkish diaspora of some 3 million people. In recent years, German officials have raised hackles in Turkiye by criticizing what they see as growing authoritarianism under Erdogan.
The outbreak of the Israel-Gaza war in Gaza has further strained ties.
Erdogan has frequently attacked Israel over its actions in Gaza, labeling them “genocide.” Berlin, meanwhile, is a strong supporter of Israel and has defended the country’s right to self-defense, although it has also increasingly called for restraint.
When the Turkish leader visited Germany last year, he traded barbs with Scholz over the conflict.
The war was sparked by Hamas’s attack on Israel on Oct. 7, 2023.
According to the territory’s Health Ministry, 42,065 people have been killed in Gaza since the start of the war, mostly civilians. There have also been tensions between Berlin and Ankara over immigration.
Berlin announced at the end of September that it had agreed a plan with Turkiye under which Berlin would step up deportations of failed Turkish asylum seekers — only for Turkiye to deny any such deal had been struck swiftly.
The Scholz government has been under heightened pressure after a series of violent crimes and extremist attacks committed by asylum seekers. When it comes to Ukraine, Germany has strongly supported Kyiv in its fight against Moscow since Russia’s full-scale invasion in 2022 and is Ukraine’s second-biggest military backer.
Turkiye has sought to balance ties between its two Black Sea neighbors, Russia and Ukraine, since the outbreak of the war. Ankara has sent drones to Ukraine but shied away from Western-led sanctions on Moscow.