LONDON: British regulators warned Wednesday that people who have a history of serious allergic reactions shouldn’t receive the new Pfizer-BioNTech vaccine as they investigate two adverse reactions that occurred on the first day of the country’s mass vaccination program.
The UK’s Medical and Healthcare Products Regulatory Agency is looking into whether the reactions were linked to the vaccine. The two people affected were staff members with the National Health Service who had a history of allergies, and both are recovering. Authorities have not specified what their reactions were.
In the meantime, the regulator has issued the warning for anyone who has had a significant allergic reaction to a vaccine, medicine or food. That includes anyone who has been told to carry an adrenaline shot or others who have had potentially fatal allergic reactions.
“As is common with new vaccines the MHRA have advised on a precautionary basis that people with a significant history of allergic reactions do not receive this vaccination after two people with a history of significant allergic reactions responded adversely yesterday,’’ Professor Stephen Powis, medical director for the NHS in England, said in a statement. “Both are recovering well.”
The medical regulatory agency also said vaccinations should not be carried out in facilities that don’t have resuscitation equipment.
Pfizer and BioNTech said they were working with investigators “to better understand each case and its causes.”
Late-stage trials of the vaccine found “no serious safety concerns,” the companies said. More than 42,000 people have received two doses of the shot during those trials.
“In the pivotal phase three clinical trial, this vaccine was generally well tolerated with no serious safety concerns reported by the independent Data Monitoring Committee,” the companies said.
Documents published by the two companies showed that people with a history of severe allergic reactions were excluded from the trials, and doctors were advised to look out for such reactions in trial participants who weren’t previously known to have severe allergies.
Even in non-emergency situations, health authorities must closely monitor new vaccines and medications because studies in tens of thousands of people can’t detect a rare risk that would affect 1 in 1 million.
Dr. Peter Openshaw, a professor of experimental medicine at Imperial College London, said there is a “very small” chance of an allergic reaction to any vaccine.
The MHRA last week gave emergency authorization to the Pfizer-BioNTech vaccine, making Britain the first country to allow its widespread use.
The UK began its mass vaccination program on Tuesday, offering the shot to people over 80, nursing home staff and some NHS workers. It’s not clear how many people have received the jab so far, the
As part of its emergency authorization for the vaccine, the MHRA required health care workers to report any adverse reactions to help regulators gather more information about safety and effectiveness.
The agency is monitoring the vaccine rollout closely and “will now investigate these cases in more detail to understand if the allergic reactions were linked to the vaccine or were incidental,” he said. “The fact that we know so soon about these two allergic reactions and that the regulator has acted on this to issue precautionary advice shows that this monitoring system is working well.”
Dr. June Raine, head of the medical regulatory agency, informed a Parliamentary committee about the reactions during previously scheduled testimony on the pandemic.
“We know from the very extensive clinical trials that this wasn’t a feature” of the vaccine, she said. “But if we need to strengthen our advice, now that we have had this experience in the vulnerable populations, the groups who have been selected as a priority, we get that advice to the field immediately.”
UK: Don’t take Pfizer vaccine if you have serious allergies
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UK: Don’t take Pfizer vaccine if you have serious allergies
- The UK advised people with a history of significant allergic reactions to not receive the Pfizer vaccine
Columbia University lays off nearly 180 after Trump pulled $400M over his antisemitism concerns
- Pro-Palestinian demonstrators set up an encampment and seized a campus building in April, leading to dozens of arrests and inspiring a wave of similar protests nationally
NEW YORK: Columbia University said Tuesday that it will be laying off nearly 180 staffers in response to President Donald Trump’s decision to cancel $400 million in funding over the Manhattan college’s handling of student protests against the war in Gaza.
Those receiving non-renewal or termination notices Tuesday represent about 20 percent of the employees funded in some manner by the terminated federal grants, the university said in a statement Tuesday.
“We have had to make deliberate, considered decisions about the allocation of our financial resources,” the university said. “Those decisions also impact our greatest resource, our people. We understand this news will be hard.”
Officials are working with the Trump administration in the hopes of getting the funding restored, they said, but the university will still pull back spending because of uncertainty and strain on its budget.
Officials said the university will be scaling back research, with some departments winding down activities and others maintaining some level of research while pursuing alternate funding.
In March, the Trump administration pulled the funding over what it described as the Ivy League school’s failure to squelch antisemitism on campus during the Israel-Hamas war that began in October 2023.
Within weeks, Columbia capitulated to a series of demands laid out by the Republican administration as a starting point for restoring the funding.
Among the requirements was overhauling the university’s student disciplinary process, banning campus protesters from wearing masks, barring demonstrations from academic buildings, adopting a new definition of antisemitism and putting the Middle Eastern studies program under the supervision of a vice provost who would have a say over curriculum and hiring.
After Columbia announced the changes, US Education Secretary Linda McMahon said the university was ” on the right track,” but declined to say when or if Columbia’s funding would be restored. Spokespersons for the federal education department didn’t immediately respond to an email seeking comment Tuesday.
Columbia was at the forefront of US campus protests over the war last spring. Pro-Palestinian demonstrators set up an encampment and seized a campus building in April, leading to dozens of arrests and inspiring a wave of similar protests nationally.
Trump, when he retook the White House in January, moved swiftly to cut federal money to colleges and universities he viewed as too tolerant of antisemitism.
Trump hopes India-Pakistan clashes end ‘very quickly’
WASHINGTON: US President Donald Trump said Tuesday he hoped clashes between nuclear-armed India and Pakistan end “very quickly,” after New Delhi’s forces launched strikes and Islamabad vowed retaliation.
“It’s a shame, we just heard about it,” Trump said at the White House, after the Indian government said it had hit “terrorist camps” on its western neighbor’s territory following a deadly attack on tourists in Indian-administered Kashmir.
“I guess people knew something was going to happen based on the past. They’ve been fighting for many, many decades and centuries, actually, if you really think about it,” he added.
India and Pakistan have fought three full-scale wars since gaining independence from the British in 1947. Both claim Kashmir in full but administer separate portions of the disputed region.
“I just hope it ends very quickly,” said Trump.
India had been widely expected to respond militarily since gunmen shot dead 26 people in Indian-administered Kashmir, mostly Hindus.
New Delhi has blamed militants that it has said were from Pakistan-based group Lashkar-e-Taiba, a UN-designated terrorist organization.
Pakistan’s army said the Indian strikes targeted three sites in Pakistan-administered Kashmir and two in Punjab province, the country’s most populous.
Islamabad said that three civilians, including a child, had been killed in Indian strikes.
The Indian strikes came just hours after the US State Department issued a fresh call for calm.
“We continue to urge Pakistan and India to work toward a responsible resolution that maintains long-term peace and regional stability in South Asia,” State Department spokeswoman Tammy Bruce told reporters.
Her statement came after Indian Prime Minister Narendra Modi warned of stopping water from flowing across borders following the Kashmir attack.
‘World cannot afford’ India-Pakistan confrontation: UN
UNITED NATIONS: UN Secretary-General Antonio Guterres was “very concerned” about Indian military strikes on Pakistan, his spokesperson said on Tuesday, hours after India said it hit nine sites in Pakistani territory.
“The Secretary-General is very concerned about the Indian military operations across the Line of Control and international border. He calls for maximum military restraint from both countries. The world cannot afford a military confrontation between India and Pakistan,” said Stephane Dujarric, the spokesperson.
Germany’s Merz vows to be ‘very European’ chancellor
BERLIN: Germany’s new Chancellor Friedrich Merz vowed Tuesday to be a “very European” leader, with the continent’s other countries hopeful Germany will take on a greater international role.
“I am influenced by my work in the European Parliament, that has shaped me a lot to this day,” Merz said after being elected chancellor by the Bundestag earlier in the day.
On his first full day in office, Merz will head Wednesday to France and then Poland seeking to boost ties with European neighbors in turbulent times.
Europe has sought to present a united front as US President Donald Trump upends long-standing security and diplomatic ties, and in the face of a hostile Russia.
But Germany has for the most part been on the sidelines since the collapse in November of former chancellor Olaf Scholz’s government, with politics all but paralyzed as the country awaited a new leader.
Asked how Germany could seek to influence talks on a possible peace deal in the Ukraine war, Merz said there was a “proven format” of Berlin working together with France and Britain.
“Germany has been quite reticent in recent months due to the transition from one government to another,” Merz told public broadcaster ZDF, before adding that he planned to “consult intensively” with London and Paris from now.
“If we can include the Poles, then it will be even better,” he added.
European countries have been worried about being sidelined in talks on the conflict, after Trump’s overtures to Russian President Vladimir Putin.
Merz has vowed a crackdown on immigration but he insisted that European neighbors’ views would be “taken into consideration.”
“I will be discussing these issues with both the French president and the Polish prime minister — we want to prepare a European policy together,” he said.
US judge blocks Trump from shuttering three small federal agencies
A federal judge on Tuesday blocked President Donald Trump’s administration from firing workers and taking other steps to shut down federal agencies that fund museums and libraries, mediate labor disputes and support minority-owned businesses.
US District Judge John McConnell in Providence, Rhode Island, agreed with 21 mostly Democrat-led states that Trump’s March executive order directing that the agencies effectively be wiped out violated the US Constitution.
“This executive order ... ignores the unshakable principles that Congress makes the law and appropriates funds, and the Executive implements the law Congress enacted and spends the funds Congress appropriated,” wrote McConnell, an appointee of Democratic former President Barack Obama.
The judge halted Trump’s order from being implemented at the US Institute of Museum and Library Services, the Minority Business Development Agency, and the Federal Mediation and Conciliation Service pending the outcome of the case.
McConnell did not order the agencies to take any specific steps. The judge told the states to consult with the Trump administration and submit a more detailed order for his approval.
Trump in his order directed that those agencies and four others be reduced “to the minimum presence and function required by law.” A judge in Washington, D.C. last week had separately blocked the museum and library agency from being shut down.
White House spokesman Davis Ingle said McConnell had defied US Supreme Court precedent by blocking Trump from closing elements of the federal bureaucracy.
“The lower court’s outrageous order will not be the last say on the matter,” Ingle said in a statement.
Rhode Island Attorney General Peter Neronha, a Democrat whose office is leading the lawsuit, called the decision a critical win for the public.
“When the Trump Administration attempts to dismantle these agencies, it is making a targeted, concerted effort to prohibit everyday people from accessing their full potential,” Neronha said in a statement.
Trump’s executive order was part of his broader effort to dramatically shrink the federal government and slash government spending. Tens of thousands of federal workers have been fired, placed on leave indefinitely or accepted buyouts to leave their jobs.
At the three agencies involved in Tuesday’s case, virtually all employees were placed on administrative leave shortly after Trump issued his executive order, according to court filings.
The states in their lawsuit filed in April say that because Congress created the agencies and set their funding levels, Trump had no power to order that their work be halted.
McConnell on Tuesday agreed. Federal law includes a mechanism for the president to return unneeded funding to Congress, the judge said, but Trump failed to follow that process.
State libraries and museums have abandoned programs and implemented hiring freezes, business development offices are curbing training and other support programs, and state agencies have fewer options to mediate disputes with unions, McConnell said.
