NEW YORK: Pfizer and BioNTech’s COVID-19 vaccine appeared to work against a key mutation in the highly transmissible new variants of the coronavirus discovered in Britain and South Africa, according to a laboratory study conducted by the US drugmaker.
The study by Pfizer and scientists from the University of Texas Medical Branch, which has not yet been peer-reviewed, indicated the vaccine was effective in neutralizing virus with the so-called N501Y mutation of the spike protein.
The mutation could be responsible for greater transmissibility and there had been concern it could also make the virus escape antibody neutralization elicited by the vaccine, said Phil Dormitzer, one of Pfizer’s top viral vaccine scientists.
The first results of tests on the variants offer a glimmer of hope while more studies are carried out as Britain and other countries try to tame the more infectious variants which authorities believe are driving a surge in infections that could overwhelm health care systems.
The Pfizer-BioNTech study was conducted on blood taken from people who had been given the vaccine. Its findings are limited because it does not look at the full set of mutations found in either of the new variants of the rapidly spreading virus.
Dormitzer said it was encouraging that the vaccine appears effective against the mutation, as well as 15 other mutations the company has previously tested against.
“So we’ve now tested 16 different mutations, and none of them have really had any significant impact. That’s the good news,” he said. “That doesn’t mean that the 17th won’t.”
Dormitzer said another mutation found in the South African variant, called the E484K mutation, was also concerning.
The researchers plan to run similar tests to establish whether the vaccine is effective against other mutations found in the British and South African variants and hope to have more data within weeks.
The variants are said by scientists to be more transmissible than previously dominant ones, but they are not thought to cause more serious illness.
Scientists said the results of the study would help calm concerns that people will not be protected by vaccines being given to millions of people around the world in the fight against the pandemic, which has killed more than 1.8 million people and roiled economies.
But they cautioned that more clinical tests and data are still needed to come to a definitive conclusion.
“This is good news, mainly because it is not bad news,” said Stephen Evans, professor of pharmacoepidemiology, London School of Hygiene & Tropical Medicine.
“So, yes this is good news, but it does not yet give us total confidence that the Pfizer (or other) vaccines will definitely give protection.”
AstraZeneca, Moderna and CureVac are also testing whether their shots work against the fast-spreading variants. They have said they expect them to be effective, but the timing of those studies are not known.
A senior British lawmaker expressed concerns in an interview on Friday that COVID-19 vaccines might not work properly against the South African variant. He was not responding to questions about Friday’s data.
The Pfizer/BioNTech vaccine and the one from Moderna, which use synthetic messenger RNA technology, can be quickly tweaked to address new mutations of a virus if necessary. Scientists have suggested the changes could be made in as little as six weeks.
The variant is not the first of the pandemic to emerge and Eleanor Riley, professor of immunology and infectious disease at the University of Edinburgh, said these types of study will be needed as they appear.
“It may be necessary to tweak the vaccine over time,” she said.
Pfizer/BioNTech vaccine appears effective against mutation in new coronavirus variants
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Pfizer/BioNTech vaccine appears effective against mutation in new coronavirus variants
- Vaccine effective in neutralizing virus with the so-called N501Y mutation of the spike protein
Suspect in German Christmas market attack held on murder charges
- Suspect strongly critical of German authorities as well as Islam in the past
- Saudi Arabia repeatedly flagged to Germany concerns over posts on suspect’s social media, according to sources
MAGDEBURG: A man suspected of plowing a car through crowds at a German Christmas market in an attack that killed five people and injured scores faces multiple charges of murder and attempted murder, police said on Sunday.
Friday evening’s attack in the central city of Magdeburg shocked the country and stirred up tensions over the charged issue of immigration.
The suspect, who was in custody, is a 50-year-old psychiatrist from Saudi Arabia with a history of anti-Islamic rhetoric who has lived in Germany for almost two decades. The motive for the attack remained unclear.
There were scuffles and some “minor disturbances” at a far-right demonstration attended by around 2,100 people on Saturday night in Magdeburg, police said. They added that criminal proceedings would follow, but did not give details.
Protesters, some wearing black balaclavas, held up a large banner with the word “remigration,” a term popular with supporters of the far right who seek the mass deportation of immigrants and people deemed not ethnically German.
Other residents gathered to pay their respects to the dead.
A sea of flowers stretched out in front of St. John’s Church in Magdeburg, close to the scene of the crime, which attracted a steady stream of tearful mourners over the weekend.
“This is my second time here. I was here yesterday. I brought flowers and it moved me so much and I had to know today how many flowers were brought,” local resident Ingolf Klinzmann told Reuters.
A sign commemorating the victims bore in large lettering the word “Why?.”
A magistrate ordered the suspect, identified in German media as Taleb A., into pretrial custody on charges of murder on five counts as well as multiple counts of attempted murder and grievous bodily harm, police said in a statement.
Reuters could not immediately ascertain if the suspect had a lawyer.
Those killed were a nine-year-old boy and four women aged 52, 45, 75 and 67, the police statement said. Among the wounded, around 40 had serious or critical injuries.
Authorities said the suspected attacker used emergency exit points to drive onto the grounds of the Christmas market, where he picked up speed and plowed into the crowds, hitting more than 200 people in a three-minute attack. He was arrested at the scene.
German authorities have not named the suspect and German media reports have given his name only as Taleb A. in keeping with local privacy laws.
MOTIVE UNCLEAR
Interior Minister Nancy Faeser said in a statement on Sunday that the criminal investigation would leave no stone unturned.
“The task is to piece together all findings and paint a picture of this perpetrator, who does not fit any existing mold,” Faeser said.
“This perpetrator acted in an unbelievably cruel and brutal manner — like an Islamist terrorist, although he was clearly ideologically hostile to Islam,” she added.
The suspect had been strongly critical of German authorities as well as Islam in the past.
He had voiced support on social media platform X for the far-right Alternative for Germany (AfD) party and for US billionaire Elon Musk, who has backed the AfD.
The AfD has strong support in the former East Germany where Magdeburg is located. Opinion polls put it in second place nationally ahead of elections in February.
Its members, including the candidate for chancellor Alice Weidel, planned a rally in Magdeburg on Monday evening.
Saudi Arabia had repeatedly flagged to Germany concerns over posts on the suspect’s social media, according to a Saudi source and a German security source.
The Christian Democrats, Germany’s main opposition party, and the Free Democrats, who were part of the coalition government until its collapse last month, called for improvements to Germany’s security apparatus, including better coordination between federal and state authorities.
“The background must be clarified. But above all, we must do more to prevent such offenses, especially as there were obviously specific warnings and tips in this case that were ignored,” Sahra Wagenknecht, leader of the leftist BSW party, told the Welt newspaper.
The BSW, a new political party with far-left roots, has also condemned unchecked immigration and has gained considerable support ahead of the Feb. 23 election.
Chancellor Olaf Scholz, whose Social Democrats are trailing in opinion polls, attended a service for victims in Magdeburg’s cathedral on Saturday.
Minorities fear targeted attacks in post-revolution Bangladesh
- In the chaotic days following Hasina’s August 5 ouster there was a string of attacks on Hindus
- Muslim Sufi worshippers as well as members of the Baul mystic sect have also been threatened
DHAKA: For generations, the small Hindu temple outside the capital in Muslim-majority Bangladesh was a quiet place to pray — before arsonists ripped open its roof this month in the latest post-revolution unrest.
It is only one of a string of attacks targeting religious minorities since a student-led uprising toppled long-time autocratic leader Sheikh Hasina in August.
“We don’t feel safe,” said Hindu devotee Swapna Ghosh in the village of Dhour, where attackers broke into the 50-year-old family temple to the goddess Lakshmi and set fire to its treasured idols on December 7.
“My son saw the flames and doused them quickly,” said temple custodian Ratan Kumar Ghosh, 55, describing how assailants knew to avoid security cameras, so they tore its tin roof open to enter.
“Otherwise, the temple — and us — would have been reduced to ashes.”
Hindus make up about eight percent of the mainly Muslim nation of 170 million people.
In the chaotic days following Hasina’s August 5 ouster there was a string of attacks on Hindus — seen by some as having backed her rule — as well as attacks on Muslim Sufi shrines by religious hard-liners.
“Neither I, my forefathers or the villagers, regardless of their faith, have ever witnessed such communal attacks,” temple guardian Ghosh told AFP.
“These incidents break harmony and trust.”
Hasina, 77, fled by helicopter to India, where she is hosted by old allies in New Delhi’s Hindu-nationalist government, infuriating Bangladeshis determined that she face trial for alleged “mass murder.”
Attacks against Hindu temples are not new in Bangladesh, and rights activist Abu Ahmed Faijul Kabir said the violence cannot be regarded out of context.
Under Hasina, Hindus had sought protection from the authorities. That meant her opponents viewed them as partisan loyalists.
“If you analyze the past decade, there has not been a single year without attacks on minorities,” Kabir said, from the Dhaka-based rights group Ain o Salish Kendra.
This year, from January to November, the organization recorded 118 incidents of communal violence targeting Hindus.
August saw a peak of 63 incidents, including two deaths. In November, there were seven incidents.
While that is significantly more than last year — when the group recorded 22 attacks on minorities and 43 incidents of vandalism — previous years were more violent.
In 2014, one person was killed, two women were raped, 255 injured, and 247 temples attacked. In 2016, seven people were killed.
“The situation has not worsened, but there’s been no progress either,” said businessman and Hindu devotee Chandan Saha, 59.
Political rulers had repeatedly “used minorities as pawns,” Saha added.
The caretaker government has urged calm and promised increased security, and accused Indian media of spreading disinformation about the status of Hindus in Bangladesh.
Dhaka’s interim government this month expressed shock at a call by a leading Indian politician — chief minister of India’s West Bengal state Mamata Banerjee — to deploy UN peacekeepers.
Hefazat-e-Islam, an association of Islamic seminaries, has led public protests against India, accusing New Delhi of a campaign aimed at “propagating hate” against Bangladesh. India rejects the charges.
Religious relations have been turbulent, including widespread unrest in November in clashes between Hindu protesters and security forces.
That was triggered by the killing of a lawyer during protests because bail was denied for an outspoken Hindu monk accused of allegedly disrespecting the Bangladeshi flag during a rally.
Bangladeshi hard-line groups have been emboldened to take to the streets after years of suppression.
Muslim Sufi worshippers as well as members of the Baul mystic sect — branded heretics by some hard-liners — have also been threatened.
“There’s been a wave of vandalism,” said Syed Tarik, a devotee documenting such incidents.
Muhammad Yunus, the 84-year-old Nobel Peace Prize winner appointed the country’s “chief adviser,” has called for dialogue between groups.
Critics say it is not enough.
“To establish a peaceful country where all faiths coexist in harmony, the head of state must engage regularly with faith leaders to foster understanding,” said Sukomal Barua, professor of religion at Dhaka University.
Sumon Roy, founder of Bangladesh’s association of Hindu lawyers, said members of the minority were treated as a bloc by political parties.
“They have all used us as tools,” Roy said, explaining that Hindus had been previously threatened both by Hasina’s Awami League and its rival Bangladesh National Party.
“If we didn’t support AL we faced threats, and the BNP blamed us for siding with the AL,” he said. “This cycle needs to end.”
India, Kuwait upgrade ties to strategic partnership on Modi visit
- Modi awarded Order of Mubarak Al-Kabeer for strengthening Kuwait-India relations
- India, Kuwait leaders discussed cooperation in pharmaceuticals, IT, security
NEW DELHI: India and Kuwait upgraded bilateral ties to a strategic partnership on Sunday as their leaders eye stronger cooperation in “key sectors” ranging from pharmaceuticals to security.
Indian Prime Minister Narendra Modi signed a strategic partnership agreement with Emir of Kuwait Sheikh Mishal Al-Ahmad Al-Jaber Al-Sabah during his trip to the Gulf state, the first visit by an Indian leader in 43 years.
“We have elevated our partnership to a strategic one and I am optimistic that our friendship will flourish even more in the times to come,” Modi said in a statement.
“We discussed cooperation in key sectors like pharmaceuticals, IT, fintech, infrastructure and security.”
During the trip, the Kuwaiti emir presented Modi with the Order of Mubarak Al-Kabeer for his efforts in strengthening Kuwait-India relations.
The order is the highest civilian honor in Kuwait and is bestowed upon leaders and heads of state.
The emir said India was a “valued partner” in the country and the Gulf region and that he “looked forward” to India playing a greater role in the realization of Kuwait Vision 2035, according to a statement issued by the Indian Ministry of External Affairs.
The newly upgraded ties will open up “further cooperation in sectors such as defense … with the Kuwaiti armed forces,” especially the navy, said Kabir Taneja, a deputy director and fellow with the strategic studies program at the Observer Research Foundation in New Delhi.
Their closer cooperation in major sectors will also “further India’s economy-first agenda,” he added.
“Pharmaceuticals, for example, is a point of strength of Indian manufacturing and can contribute to further building the sector in states such as Kuwait,” Taneja told Arab News.
India’s pharmaceutical exports have been growing in recent years, and the country was the third-largest drugmaker by volume in 2023.
Delhi is also among Kuwait’s top trade partners, with bilateral trade valued at around $10.4 billion in 2023-24.
Taneja said India-Kuwait ties are also likely to strengthen through the Indian diaspora, the largest expatriate community in the Gulf state.
Over 1 million Indian nationals live and work in Kuwait, making up about 21 percent of its 4.3 million population and 30 percent of its workforce.
“(The) Indian diaspora has been part of the Kuwaiti story for a long time,” Taneja said, adding that strengthening ties between the two countries will allow India, through its diaspora, to unlock “deeper economic cooperation potential.”
Putin vows more ‘destruction’ on Ukraine after drone attack on Russia’s Kazan
- ‘Whoever, and however much they try to destroy, they will face many times more destruction themselves and will regret what they are trying to do in our country’
MOSCOW: Russian President Vladimir Putin on Sunday vowed to bring more “destruction” to Ukraine in retaliation for a drone attack on a high-rise apartment block in the central Russian city of Kazan a day earlier.
“Whoever, and however much they try to destroy, they will face many times more destruction themselves and will regret what they are trying to do in our country,” Putin said in comments on the attack on Kazan — which left no casualties — during a televised government meeting.
France’s most powerful nuclear reactor finally comes on stream
- The Flamanville 3 European Pressurized Reactor in Normandy started providing electricity to French homes on Saturday
- Launch is welcome news for the heavily indebted state-owned energy company EDF after multiple problems extended construction to 17 years
PARIS: France on Saturday connected its most powerful nuclear power reactor to the national electricity grid in what leaders hailed as a landmark moment despite years of delays, budget overruns and technical setbacks.
The Flamanville 3 European Pressurized Reactor in Normandy started providing electricity to French homes at 11:48 a.m. (1048 GMT) Saturday, the EDF power company’s CEO Luc Remont said in a statement.
“Great moment for the country,” President Emmanuel Macron said in a statement on social network LinkedIn, calling it “one of the world’s most powerful nuclear reactors.”
“Re-industrializing to produce low-carbon energy is French-style ecology,” he added. “It strengthens our competitiveness and protects the climate.”
The French-developed European Pressurised Reactor project, launched in 1992, was designed to relaunch nuclear power in Europe after the 1986 Chernobyl catastrophe in Soviet Ukraine, and is touted as offering more efficient power output and better safety.
The EPR, a new generation pressurized water reactor, is the fourth to be finished anywhere in the world. Similar design reactors in China and Finland came online ahead of it.
The launch is welcome news for the heavily indebted state-owned energy company EDF after multiple problems extended construction to 17 years and caused massive budget overruns.
Remont of EDF called the event “historic.”
“The last time a reactor started up in France was 25 years ago at Civaux 2,” he said, referring to the Civaux power plant in southwestern France.
The connection was initially scheduled to take place Friday.
It is the most powerful reactor in the country at 1,600 MW. Ultimately, it should supply electricity to upwards of two million homes.
The connection to the grid “will be marked by different power levels through to the summer of 2025” in a months-long testing phase, the company has said.
EDF said that starting up a reactor was “a long and complex operation.”
The plant will be shut down for a complete inspection lasting at least 250 days, probably in the spring of 2026, the company added.
Construction of the Flamanville reactor began in 2007 and was beset by numerous problems.
The start-up comes 12 years behind schedule after a plethora of technical setbacks which saw the cost of the project soar to an estimated 13.2 billion euros ($13.76 billion), four times the initial 3.3 billion euro estimate.
The start-up began on September 3, but had to be interrupted the following day due to an “automatic shutdown.” It resumed a few days later.
Generation has been gradually increased to allow the reactor to be connected to the electricity network.
Nuclear power accounts for around three-fifths of French electricity output and the country boasts one of the globe’s largest nuclear power programs.
That is in stark contrast to neighboring Germany, which exited nuclear power last year by shutting down the last three of its reactors.
“This morning marks the culmination of a titanic effort that has finally paid off,” Agnes Pannier-Runacher, the outgoing minister for ecological transition, said on X.
“We are drawing all the lessons from this to make a success of the nuclear revival that we decided on with the President of the Republic.”
Macron has decided to ramp up nuclear power to bolster French energy sustainability by ordering six new-generation reactors and laying options for eight more, that could cost tens of billions of euros.
In 2022, he called for a “renaissance” for the country’s nuclear industry to transition away from fossil fuels.
“What we have to build today is the renaissance of the French nuclear industry because it’s the right moment, because it’s the right thing for our nation, because everything is in place,” Macron said at the time.
