NEW YORK: Pfizer and BioNTech’s COVID-19 vaccine appeared to work against a key mutation in the highly transmissible new variants of the coronavirus discovered in Britain and South Africa, according to a laboratory study conducted by the US drugmaker.
The study by Pfizer and scientists from the University of Texas Medical Branch, which has not yet been peer-reviewed, indicated the vaccine was effective in neutralizing virus with the so-called N501Y mutation of the spike protein.
The mutation could be responsible for greater transmissibility and there had been concern it could also make the virus escape antibody neutralization elicited by the vaccine, said Phil Dormitzer, one of Pfizer’s top viral vaccine scientists.
The first results of tests on the variants offer a glimmer of hope while more studies are carried out as Britain and other countries try to tame the more infectious variants which authorities believe are driving a surge in infections that could overwhelm health care systems.
The Pfizer-BioNTech study was conducted on blood taken from people who had been given the vaccine. Its findings are limited because it does not look at the full set of mutations found in either of the new variants of the rapidly spreading virus.
Dormitzer said it was encouraging that the vaccine appears effective against the mutation, as well as 15 other mutations the company has previously tested against.
“So we’ve now tested 16 different mutations, and none of them have really had any significant impact. That’s the good news,” he said. “That doesn’t mean that the 17th won’t.”
Dormitzer said another mutation found in the South African variant, called the E484K mutation, was also concerning.
The researchers plan to run similar tests to establish whether the vaccine is effective against other mutations found in the British and South African variants and hope to have more data within weeks.
The variants are said by scientists to be more transmissible than previously dominant ones, but they are not thought to cause more serious illness.
Scientists said the results of the study would help calm concerns that people will not be protected by vaccines being given to millions of people around the world in the fight against the pandemic, which has killed more than 1.8 million people and roiled economies.
But they cautioned that more clinical tests and data are still needed to come to a definitive conclusion.
“This is good news, mainly because it is not bad news,” said Stephen Evans, professor of pharmacoepidemiology, London School of Hygiene & Tropical Medicine.
“So, yes this is good news, but it does not yet give us total confidence that the Pfizer (or other) vaccines will definitely give protection.”
AstraZeneca, Moderna and CureVac are also testing whether their shots work against the fast-spreading variants. They have said they expect them to be effective, but the timing of those studies are not known.
A senior British lawmaker expressed concerns in an interview on Friday that COVID-19 vaccines might not work properly against the South African variant. He was not responding to questions about Friday’s data.
The Pfizer/BioNTech vaccine and the one from Moderna, which use synthetic messenger RNA technology, can be quickly tweaked to address new mutations of a virus if necessary. Scientists have suggested the changes could be made in as little as six weeks.
The variant is not the first of the pandemic to emerge and Eleanor Riley, professor of immunology and infectious disease at the University of Edinburgh, said these types of study will be needed as they appear.
“It may be necessary to tweak the vaccine over time,” she said.
Pfizer/BioNTech vaccine appears effective against mutation in new coronavirus variants
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Pfizer/BioNTech vaccine appears effective against mutation in new coronavirus variants
- Vaccine effective in neutralizing virus with the so-called N501Y mutation of the spike protein
Trump signs order to get ‘transgender ideology’ out of military
- He signed further orders reinstating service members dismissed for refusing to take the COVID-19 vaccine
- He extended a wider government crackdown on diversity programs to the armed forces
In a series of orders related to the military that Trump told reporters he had signed on Air Force One, he also called for the building of a US version of Israel’s Iron Dome missile defense system.
The Republican signed further orders reinstating service members dismissed for refusing to take the COVID-19 vaccine, and extending a wider government crackdown on diversity programs to the armed forces.
“To ensure that we have the most lethal fighting force in the world, we will get transgender ideology the hell out of our military,” Trump told a Republican congressional retreat earlier in Miami.
Trump has previously promised to bring back a ban on transgender troops, but it was not immediately clear what specific steps were contained in the new order, which has not yet been published.
A White House official with him said the order involved “eliminating gender radicalism in the military.”
Trump’s orders came at the start of his second week back in the White House and on the day a welcome ceremony was held at the Pentagon for his new defense secretary, military veteran and Fox News personality Pete Hegseth.
“Thank you for your leadership Mr. President. We will execute!” Hegseth — who was confirmed last week despite concerns over his inexperience, and alleged record of heavy drinking and domestic violence — said on X.
Transgender Americans have faced a roller coaster of changing policies on military service in recent years, with Democratic administrations seeking to permit them to serve openly while Trump has repeatedly sought to keep them out of the ranks.
The US military lifted a ban on transgender troops serving in the armed forces in 2016, during Democrat Barack Obama’s second term as president.
Under that policy, trans troops already serving were permitted to do so openly, and transgender recruits were set to start being accepted by July 1, 2017.
But the first Trump administration postponed that date to 2018 before deciding to reverse the policy entirely, sparking criticism from rights groups.
Trump claimed that transgender service members were disruptive, expensive and eroded military readiness and camaraderie among troops.
Trump’s Democratic successor Joe Biden moved to reverse the restrictions just days after he took office in 2021, saying all Americans qualified to serve should be able to do so.
While the number of transgender troops in the American military is fairly small — with estimates of some 15,000 out of more than two million uniformed service members — their dismissal would reduce US forces at a time when the country is already facing difficulties recruiting new personnel.
Biden’s outgoing defense secretary Lloyd Austin appeared to criticize Trump’s plans during a farewell address earlier this month, saying: “Any military that turns away qualified patriots who are eager to serve is just making itself smaller and weaker.”
Transgender issues have roiled US politics in recent years, as states controlled by Democrats and Republicans have moved in opposite directions on policies ranging from medical treatment to what books on the topic are allowed in public or school libraries.
Trump has meanwhile repeatedly promised to build a version of the Iron Dome system that Israel has used to shoot down missiles fired by Hamas from Gaza and Hezbollah in Lebanon.
But he ignored the fact that the system is designed for short-range threats, making it ill-suited to defending against intercontinental missiles that are the main danger to the United States.
“We need to immediately begin the construction of a state-of-the-art Iron Dome missile defense shield,” Trump said in Miami, adding that it would be “made right here in the USA.”
EU, Britain to face off in post-Brexit fishing battle case
The bitter arbitration case over sandeels is seen as a bellwether for other potential litigation between London and Brussels in a perennial hot-bed industry, experts said.
Tuesday’s clash at the Hague-based Permanent Court for Arbitration also marks the first courtroom trade battle between the 27-member trading bloc and Britain since it left the EU in 2020.
Brussels has dragged London before the PCA following a decision last year to ban all commercial fishing of sandeels in British waters because of environmental concerns.
London in March ordered all fishing to stop, saying in court documents that “sandeels are integral to the marine ecosystem of the North Sea.”
Because of climate change and commercial fishing, the tiny fish “risked further decline... as well as species that are dependent on sandeels for food including fish, marine mammals, and seabirds.”
This included vulnerable species like the Atlantic puffin, seals, porpoises and other fish like cod and haddock, Britain’s lawyers said.
But Brussels is accusing London of failing to keep to commitments made under the landmark Trade and Cooperation Agreement, which gave the EU access to British waters for several years during a transition period after London’s exit.
Under the deal, the EU’s fishing fleet retained access to British waters for a five-and-half-year transition period, ending mid-2026. After that, access to respective waters will be decided in annual negotiations.
“The EU does not call into question the right of the UK to adopt fisheries management measures in pursuit of legitimate conservation objectives,” Brussels’ lawyers said in court papers.
“Rather, this dispute is about the UK’s failure to abide by its commitments under the agreement.”
London failed to apply “evidence-based, proportionate and non-discriminatory measures when restricting the right to EU vessels to full access to UK waters to fish sandeel,” the EU lawyers said.
Brussels is backing Denmark in the dispute, whose vessels take some 96 percent of the EU’s quota for the species, with sandeel catches averaging some £41.2 million (49 million euros) annually.
“The loss of access to fisheries in English waters could affect relations with the EU, including Denmark, as they are likely to lead to employment losses and business losses overseas,” the EU’s lawyers warned.
The case will now be fought out over three days at the PCA’s stately headquarters at the Peace Palace in The Hague, which also houses the International Court of Justice.
Set up in 1899, the PCA is the world’s oldest arbitral tribunal and resolves disputes between countries and private parties through referring to contracts, special agreements and various treaties, such as the UN Convention on the Law of the Sea.
The EU’s decision to open a case before the PCA “will not have been taken lightly and reflected the political importance it places on fishing rights,” writes Joel Reland, a senior researcher at UK in a Changing Europe, a London-based think tank.
In a number of “influential member states — including France, the Netherlands and Denmark — fishing rights are an important issue, with many communities relying on access to British waters for their livelihoods.”
“This dispute is an early warning that the renegotiation of access rights, before the TCA fisheries chapter expires in June 2026, will be critical for the EU,” said Reland.
A ruling in the case is expected by the end of March.
Trump says will build ‘Iron Dome’ missile shield
- The system “will be made right here in the USA,” the president said
MIAMI: President Donald Trump said Monday he would sign an executive order to start building an “Iron Dome” air defense system for the United States, like the one that Israel has used to intercept thousands of rockets.
“We need to immediately begin the construction of a state-of-the-art Iron Dome missile defense shield, which will be able to protect Americans,” Trump told a Republican congressional retreat in Miami.
Trump said the system “will be made right here in the USA.”
Speaking on the day new Defense Secretary Pete Hegseth took office, Trump said it was one of four orders he would sign, along with one that would “get transgender ideology the hell out of our military.”
During the 2024 election campaign Trump repeatedly promised to build a version of Israel’s Iron Dome system for the United States
But he ignored the fact that the system is designed for short-range threats, making it ill-suited to defending against intercontinental missiles that are the main danger to the United States.
Trump however again sung the praises of the Israeli system, which Israel has used to shoot down rockets fired by its regional foes Hamas in Gaza and Hezbollah in Lebanon during the war sparked by the October 7 Hamas attack on Israel.
“They knock down just about every one of them,” Trump said. “So I think the United States is entitled to that.”
Ukraine’s Zelensky says war means mobilization rules cannot be changed
- Members of some units in areas deemed critical to ensuring Ukraine’s defensive lines have not enjoyed any leave since Russia launched its full-scale invasion of the country in February 2022
Ukrainian President Volodymyr Zelensky said on Monday that the rigours of nearly three years of war did not allow for changes in mobilization rules because if soldiers left for home en masse, Russian President Vladimir Putin “will kill us all.”
Zelensky told Italian journalist Cecilia Sala, who was released this month after being detained for 21 days in Iran, that the toll of war on Ukrainians and their families underscored the need to bring the conflict rapidly to an end.
Parliament approved new mobilization rules last year to boost numbers of those at the front, but Ukraine’s fighting forces are still badly outnumbered by their Russian adversaries.
“The wartime situation calls for mobilization of people and all the resources we have in the country. Absolutely all of them,” Zelensky said in the interview, excerpts of which were posted on the president’s Telegram channel.
“And, unfortunately, that is the challenge of this war and that is why we have to speed things up to the maximum to end it, to oblige Russia to end this war,” Zelensky said.
“Today, we are defending ourselves. If tomorrow, for instance, half the army heads home, we really should have surrendered on the very first day. That is how it is. If half the army goes home, Putin will kill us all.”
The legislation approved last year, lowered the age of mobilization for Ukrainian men from 27 to 25 years, narrowed exemptions and imposed penalties on evaders.
Zelensky and others have rejected suggestions by politicians in the United States, Ukraine’s biggest Western backer, that the draft age be lowered further on grounds that Ukrainian forces at the front are not sufficiently well armed.
Members of some units in areas deemed critical to ensuring Ukraine’s defensive lines have not enjoyed any leave since Russia launched its full-scale invasion of the country in February 2022.
Russian forces failed in their initial advance on the capital Kyiv, but have since focused their efforts on securing all of Donbas, made up of Donetsk and Luhansk regions, in Ukraine’s east.
Russian forces occupy about 20 percent of Ukraine’s territory and have been recording their fastest gains since the invasion in their advance in the east, while holding part of four Ukrainian regions.Ukrainian President Volodymyr Zelensky
US Justice Dept officials involved in Trump prosecutions fired
WASHINGTON: The US Justice Department fired a number of officials on Monday who were involved in the criminal prosecutions of President Donald Trump.
“Acting attorney general James McHenry made this decision because he did not believe these officials could be trusted to faithfully implement the president’s agenda because of their significant role in prosecuting the president,” a Justice Department official said.
The official did not specify now many people had their employment terminated, but US media outlets said it was more than a dozen and several were career prosecutors with the Justice Department.
Special Counsel Jack Smith, who brought two federal cases against Trump, resigned earlier this month.
Smith charged Trump with plotting to overturn the results of the 2020 election and mishandling classified documents after leaving the White House.
Neither case came to trial and Smith — in line with a long-standing Justice Department policy of not prosecuting a sitting president — dropped them both after the Republican won November’s presidential election.
The firing of the Justice Department officials involved in prosecuting Trump was not unexpected.
Trump had vowed before the election to fire Smith “on day one” and accused the Justice Department under Democratic president Joe Biden of conducting a “political witchhunt” against him.
In his inauguration speech, Trump said he would end the “vicious, violent, and unfair weaponization of the Justice Department and our government.”
In his final report, Smith said Trump would have been convicted for his “criminal efforts” to retain power after the 2020 election if the case had not been dropped.
Trump was charged with conspiracy to defraud the United States and conspiracy to obstruct an official proceeding — the session of Congress held to certify Biden’s win that was violently attacked on January 6, 2021 by a mob of Trump supporters.
Smith also prepared a report into Trump’s alleged mishandling of classified documents but it is being withheld because charges are pending against two of his former co-defendants.
Trump faces separate racketeering charges in Georgia over his efforts to subvert the election results in the southern state, but the case will likely be frozen while he is in office.
Trump was convicted in New York in May of falsifying business records to cover up hush money payments to a porn star. The judge who presided over the case gave him an “unconditional discharge” which carries no jail time, fine or probation.
