LONDON: Novavax Inc. said Thursday that its COVID-19 vaccine appears 89% effective based on early findings from a British study and that it also seems to work — though not as well — against new mutated versions of the virus circulating in that country and South Africa.
The announcement comes amid worry about whether a variety of vaccines being rolled out around the world will be strong enough to protect against worrisome new variants – and as the world desperately needs new types of shots to boost scarce supplies.
The study of 15,000 people in Britain is still underway. But an interim analysis found 62 participants so far have been diagnosed with COVID-19 – only six of them in the group that got vaccine and the rest who received dummy shots.
The infections occurred at a time when Britain was experiencing a jump in COVID-19 caused by a more contagious variant. A preliminary analysis found over half of the trial participants who became infected had the mutated version. The numbers are very small, but Novavax said they suggest the vaccine is nearly 96% effective against the older coronavirus and nearly 86% effective against the new variant. The findings are based on cases that occurred at least a week after the second dose.
“Both those numbers are dramatic demonstrations of the ability of our vaccine to develop a very potent immune response,” Novavax CEO Stanley Erck said in a call with investors late Thursday.
Scientists have been even more worried about a variant first discovered in South Africa that carries different mutations. Results from a smaller Novavax study in that country suggests the vaccine does work but not nearly as well as it does against the variant from Britain.
The South African study included some volunteers with HIV. Among the HIV-negative volunteers, the vaccine appears 60% effective. Including volunteers with HIV, overall the protection was 49%, the company said. While genetic testing still is underway, so far about 90% of the COVID-19 illnesses found in the South African study appear due to the new mutant.
“These are good results. There is reason to be optimistic” about the 60% effectiveness, said Glenda Gray, head of the South African Medical Research Council. Even against the new variant that now causes more than 90% of new cases in that country, “we’re still seeing vaccine efficacy,” she said.
More concerning is what the study showed about a totally different question — the chances of people getting COVID-19 a second time, said the leader of the South African study, Shabir Madhi of the University of the Witwatersrand in Johannesburg. Tests suggested that nearly a third of study participants had been previously infected, yet rates of new infections in the placebo group were similar.
“Past infection with early variants of the virus in South Africa does not protect” against infection with the new one, he said. “There doesn’t seem to be any protection derived.”
Novavax said it needs some additional data before it can seek British authorization for the vaccine’s use, sometime in the next month or so. A larger study in the US and Mexico has enrolled slightly over half of the needed 30,000 volunteers. Novavax said it’s not clear if the Food and Drug Administration will need data from that study, too, before deciding whether to allow US use.
Meanwhile, it is starting to develop a version of the vaccine that could more specifically target the mutations found in South Africa, in case health authorities eventually decide that updated dosing is needed.
Vaccines against COVID-19 train the body to recognize the new coronavirus, mostly the spike protein that coats it. But the Novavax candidate is made differently than the first shots being used. Called a recombinant protein vaccine, the Maryland company uses genetic engineering to grow harmless copies of the coronavirus spike protein in insect cells. Scientists extract and purify the protein and then mix in an immune-boosting chemical.
Novavax COVID-19 vaccine works, but less so against variants
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Novavax COVID-19 vaccine works, but less so against variants
- Novavax said the figures suggest their vaccine is nearly 96% effective against the older coronavirus and 86% against the new variant
South Korean court issues warrants to detain impeached President Yoon Suk Yeol and search his office
South Korean court issues warrants to detain impeached President Yoon Suk Yeol and search his office
- The country’s anti-corruption agency said it is investigating whether Yoon’s declaration amounted to rebellion
- But experts still say there is little chance of detention or searches unless he is formally removed from office
The country’s anti-corruption agency said it is investigating whether his declaration amounted to rebellion. But experts still say there is little chance of detention or searches unless Yoon is formally removed from office.
The Seoul Western District Court issued warrants to detain Yoon and to search the presidential office and residence in central Seoul, according to a statement from the Corruption Investigation Office for High-Ranking Officials, which is leading a joint investigation with police and military authorities.
Under South Korean law, the leader of a rebellion can face the death penalty or life imprisonment if convicted. Yoon has presidential immunity from most criminal prosecution, but the privilege does not extend to allegations of rebellion or treason.
Yoon’s powers have been suspended since the opposition-controlled National Assembly voted to impeach him on Dec. 14 over his imposition of martial law, which drew hundreds of troops and police officers into Seoul streets.
Yoon has argued his decree was a legitimate act of governance, calling it a warning to the main liberal opposition Democratic Party, which he has called “a monster” and “anti-state forces” that has used its legislative majority to impeach top officials, undermine the government’s budget, and which he claims sympathizes with North Korea.
The Constitutional Court is to determine whether to dismiss Yoon as president or reinstate him.
Experts said Yoon is likely to ignore the warrants. He’s ignored repeated requests by investigative authorities to appear for questioning, and the presidential security service has blocked attempts to search his office and residence citing a law that bans raids on sites with state secrets.
A lawyer for Yoon rejected the anti-corruption agency’s request for warrants on Monday, arguing it lacked legal authority to investigate rebellion charges.
The anti-corruption agency said it has no immediate plans on how to proceed with the warrants.
“Unless Yoon voluntarily lets them detain him, there is no way to detain him,” said Choi Jin, director of the Seoul-based Institute of Presidential Leadership. “Should investigators have hand-to-hand fights with the security service?”
Choi said that investigators were still likely to visit Yoon’s residence to show they are strictly and fairly carrying out their work.
Park Sung-min, president of Seoul-based political consulting firm MIN Consulting, said the push for an arrest warrant is likely an attempt to pressure Yoon to cooperate with investigations.
Former President Park Geun-hye, who was thrown out of office in 2017 following an impeachment over a corruption scandal, also refused to meet with prosecutors while in office. She underwent questioning by them and was arrested after the Constitutional Court removed her from office.
Yoon’s imposition of martial law lasted only six hours but triggered huge political turmoil, halting high-level diplomacy and rattling financial markets. Despite Yoon’s deployment of troops and police, enough lawmakers managed to enter the assembly chamber to overturn it unanimously.
Yoon’s defense minister, police chief and several top military commanders have already been arrested over their roles in the martial law enactment.
Yoon has claimed he wasn’t trying to stop the functioning of the assembly, saying that the troops were sent to maintain order, and also denied planning to arrest politicians. But comments by now-arrested commanders of military units sent to the assembly have contradicted this claim. Kwak Jong-keun, the commander of the Army Special Warfare Command, testified at the National Assembly that Yoon called on troops to “quickly knock down the door and drag out the lawmakers who are inside.” Kwak said he did not carry out Yoon’s orders.
The country’s political crisis deepened last Friday, when the Democratic Party and other small opposition parties voted to impeach acting President Han Duck-soo as well over wrangling over his refusal to fill in three justice seats at the Constitutional Court. Observers say adding more justices could affect the court’s ruling on Yoon’s impeachment.
The deputy prime minister and finance minister, Choi Sang-mok, has become South Korea’s new interim leader.
Declassified files show UK anger at Chirac over Iraq
- Blair expressed “sorrow, regret and apology” for mistakes made in planning the conflict, while his influential press chief at the time of the war, Alastair Campbell, said the decision would “weigh heavily on him”
LONDON: Newly-declassified UK government documents published Tuesday reveal the frustrations of then-prime minister Tony Blair and his government with French leader Jaques Chirac for blocking UN-backed military action in Iraq in 2003.
Minutes of an emergency cabinet meeting on March 17, 2003 — a week after Chirac said he would veto any resolution approving military action — showed UK ministers agreed “the French attitude had undermined the mechanism of the UN to enforce the will of the international community.”
“We had tried our utmost” but the French “were not prepared to accept that if President Saddam Hussein of Iraq did not comply with UN obligations, military action should follow,” Blair told the meeting, according to files released by the National Archives.
Britain joined the US-led military action to oust Saddam in 2003, despite fierce opposition across the country, with Blair highlighting allegations that the Iraqi dictator had stockpiled weapons of mass destruction.
The WMD accusations fueled by the administration of then president George W. Bush were later proven to be false.
According to the files, then foreign minister Jack Straw told cabinet “effectively, one member of the UN Security Council had torpedoed the whole process,” and accused Chirac, who died in 2019, of deciding to “open up a strategic divide between France and the UK.”
In a meeting three days later, Straw said Chirac “appeared to be positioning himself ... (to) become leader of one side of the bi-polar world he advocated,” in contrast to a US-dominated world.
By contrast, ministers were told in the March 17 meeting that the Labour government “was motivated by a world view which promoted justice, good governance and pluralism and this set it apart from other governments of the industrialized world.”
The final minute of the meeting read: “Summing up, the prime minister said that the diplomatic process was now at an end; Saddam Hussein would be given an ultimatum to leave Iraq; and the House of Commons would be asked to endorse the use of military action against Iraq to enforce compliance, if necessary.”
The UK joined the US-led invasion of Iraq on March 20, 2003, despite around one million people marching in London to protest against military intervention.
The invasion and subsequent war severely dented Blair’s popularity, culminating in the independent Chilcot inquiry, which concluded in 2016 he had deliberately exaggerated the threat posed by the Iraqi regime.
Blair expressed “sorrow, regret and apology” for mistakes made in planning the conflict, while his influential press chief at the time of the war, Alastair Campbell, said the decision would “weigh heavily on him.”. “for the rest of his days.”
Campbell was also caught up in controversy when the BBC reported he had “sexed up” a dossier on Iraq’s military capabilities, claims he has denied.
US soldier dies in non-combat incident in Iraq
- In September, the US announced an agreement with the Iraqi government to wrap up the American-led coalition’s military mission against the Daesh group in Iraq by 2025
WASHINGTON: A 34-year-old soldier serving with the Indiana National Guard in Iraq has died in a non-combat incident, the Army said Monday.
Capt. Eric Richard Hart, 34, of Indianapolis, Indiana, died Saturday in Iraq, the Army National Guard said in a statement. Hart was assigned to the Headquarters and Headquarters Battalion of Indiana’s 38th Infantry Division in Iraq. His death is under investigation.
While all combat operations have ceased for US forces in Iraq, the US maintains a presence of 2,500 troops to assist the Iraqi military in counter-Daesh operations and training. Those forces have repeatedly come under attack in the 14 months since Hamas attacked Israel, spurring a wider, deadly response from Tel Aviv.
During the last year, Iranian-backed forces have launched one-way attack drones, rockets and missiles at US facilities in Iraq in response to Israel’s military operations in Gaza and Lebanon.
In September, the US announced an agreement with the Iraqi government to wrap up the American-led coalition’s military mission against the Daesh group in Iraq by 2025. US troops have departed some bases that they have long occupied during a two-decade-long military presence in the country.
Washington has had a continuous presence in Iraq since its 2003 invasion. Although all US combat forces left in 2011, thousands of troops returned in 2014 to help the Iraqi government defeat Daesh.
Since the extremist group lost its hold on the territory it once seized, Iraqi officials have periodically called for a withdrawal of coalition forces, particularly in the wake of a US airstrike in January 2020 that killed Iranian Gen. Qassem Soleimani and Iraqi militia leader Abu Mahdi Al-Muhandis outside the Baghdad airport.
Before Monday’s announcement, a total of 4,419 troops had died in Iraq since the beginning of the 2003 Operation Iraqi Freedom military campaign, including 3,482 combat deaths and 937 non-combat deaths, according to the latest Defense Department data. A total of 31,993 troops were wounded in action in Iraq.
The Defense Department’s summary does not include all of the forces who returned from war with wounds that surfaced later, such as post-traumatic stress disorder or toxic exposure.
Bad weather set to hit UK New Year celebrations
- Edinburgh’s Hogmanay street party was canceled on public safety grounds
LONDON: Adverse weather on Monday looked set to hit UK New Year festivities, as the organizers of Edinburgh’s Hogmanay street party canceled the event on public safety grounds.
The Edinburgh celebrations, a major tourist draw which last year attracted some 30,000 people, had been due to feature a fireworks display and a concert headlined by Scottish band Texas.
But organizers said it would not be safe to go ahead with preparations for outdoor events scheduled for Monday and New Year’s Eve on Tuesday due to “ongoing high winds and inclement weather.”
Planned New Year fireworks in the holiday resort town of Blackpool in northwestern England were also canceled due to a forecast of high winds, the local council said.
The Scottish Environment Protection Agency (Sepa) issued a rare severe flood warning of “danger to life” for parts of Scotland.
It said a heavy downpour was expected to burst riverbanks in Aviemore in northern Scotland and nearby areas of the Scottish Highlands.
“Due to persistent and heavy rainfall, river levels on the River Spey will rise throughout Monday night and into Tuesday morning causing serious flooding,” it said.
“Extensive flooding to properties and businesses is expected in and around Aviemore.”
The UK’s Met Office, meanwhile, said heavy rain and strong winds could be expected in parts of Scotland, Northern Ireland and northern England.
Some snow was also forecast for parts of Scotland.
“A series of low-pressure systems will track across the UK over the next couple of days bringing some potentially disruptive weather,” said Met Office meteorologist Steve Willington.
“Almost the entire UK is covered by at least one weather warning” over the coming week, he added.
A Met Office amber warning for rain and snow — the second most severe weather notice, meaning there is a potential risk to life — is in place for Scotland.
A number of less severe yellow warnings for rain, wind and snow were also in place for Scotland and northern England.
US Treasury says was targeted by China state-sponsored cyberattack
- Breach accessed Treasury workstations and some unclassified documents
WASHINGTON: The US Treasury Department said Monday that a China state-sponsored actor was behind a cyber breach resulting in access to some of its workstations, according to a letter to Congress seen by AFP.
The incident happened earlier this month, when the actor compromised a third-party cybersecurity service provider and was able to remotely access the Treasury workstations and some unclassified documents, a Treasury spokesperson added.
Treasury contacted the US Cybersecurity and Infrastructure Security Agency after it was alerted of the situation by its provider BeyondTrust, and has been working with law enforcement partners to ascertain the impact.
“The compromised BeyondTrust service has been taken offline and there is no evidence indicating the threat actor has continued access to Treasury systems or information,” the department’s spokesperson said.
In its letter to the leadership of the Senate Banking Committee, the Treasury said: “Based on available indicators, the incident has been attributed to a China state-sponsored Advanced Persistent Threat (APT) actor.”
An APT refers to a cyberattack where an intruder establishes and maintains unauthorized access to a target, remaining undetected for a sustained period of time.
The department did not provide further details on what was affected by the breach, but said more information would be released in a supplemental report at a later date.
“Treasury takes very seriously all threats against our systems, and the data it holds,” the Treasury spokesperson added.
The official said that the department would continue working to protect the US financial system from threats.
Several countries, notably the United States, have voiced alarm in recent years at what they say is Chinese-government-backed hacking activity targeting their governments, militaries and businesses.
Beijing rejects the allegations, and has previously said that it opposes and cracks down on all forms of cyberattacks.
In September, the US Justice Department said it had neutralized a cyber-attack network that affected 200,000 devices worldwide, alleging it was run by hackers backed by the Chinese government.
In February, US authorities also said they had dismantled a network of hackers known as “Volt Typhoon.”
The group was said to be targeting key public sector infrastructure like water treatment plants and transportation systems at the behest of China.
In 2023, tech giant Microsoft said Chinese-based hackers seeking intelligence information breached the email accounts of a number of US government agencies.
The group, Storm-0558, had breached email accounts at approximately 25 organizations and government agencies.
Accounts belonging to the State Department and Commerce Secretary Gina Raimondo were among those hacked in that breach.
