LONDON: Treating COVID-19 patients at home with a commonly-used inhaled asthma drug called budesonide can speed up their recovery, according to UK trial results on Monday which doctors said could change the way the disease is treated around the world.
Researchers behind the trial — known as PRINCIPLE — said the findings were only an interim analysis at this stage, but could soon lead doctors to prescribe budesonide inhalers to patients infected with COVID-19 but not sick enough to be hospitalized.
“For the first time we have high-quality evidence of an effective treatment that can be rolled out across the community for people who are at most risk of developing more severe illness from COVID-19,” said Richard Hobbs, a professor at Britain’s Oxford University who co-led the trial.
He noted that unlike other proven COVID-19 treatments, such as the steroid dexamethasone, budesonide is effective in early stages of COVID-19 and can be used at home. “This is a significant milestone for this pandemic,” he said.
The PRINCIPLE results add to recent evidence from a smaller UK study, which found in February that budesonide reduced recovery time and the need for hospitalization among COVID-19 patients given it within a week of first symptoms.
Budesonide is a safe, relatively cheap and readily available corticosteroid drug used around the world in inhalers to treat asthma and chronic obstructive pulmonary disease (COPD).
“Medical practitioners around the world caring for people with COVID-19 in the community may wish to consider this evidence when making treatment decisions,” said Chris Butler, a family doctor and Oxford professor who co-led the PRINCIPLE study. “It should help people with COVID-19 recover quicker.”
The study involved 961 patients who were randomly assigned to receive inhaled budesonide and compared to 1,819 patients assigned to the usual standard of care. Some 751 people in the budesonide group and 1,028 in the usual care group were SARS-CoV-2 positive and included in the interim analysis.
Doctors asked the budesonide patients to take two puffs on the inhaler, twice a day for a fortnight — giving an inhaled dose of 800 micrograms twice a day for 14 days. All patients were either age 65 plus, or aged over 50 with an underlying health condition that put them at more risk of serious COVID-19.
Interim results, published before peer-review on the medRxiv server, showed that 32% of those on inhaled budesonide, compared to 22% in the usual care group, recovered within the first 14 days and remained well until at least 28 days of follow-up.
Butler’s team said a full analysis with detailed results on time to recovery and hospitalizations would be published when all remaining trial patients have completed follow-up.
Asthma drug budesonide speeds recovery for at-home COVID-19 patients
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Asthma drug budesonide speeds recovery for at-home COVID-19 patients
- Budesonide is a safe, relatively cheap and readily available drug used to treat asthma
- Doctors said the discovery could change the way Covid-19 is treated around the world
Leading British Muslims back new community network in UK
- Early discussions with the government and opposition parties are underway, and the launch event is expected to feature senior political figures
LONDON: A new national body, the British Muslim Network, launches next month with the aim of providing a mainstream voice for Britain’s Muslim communities and engaging directly with the government, The Times newspaper reported on Friday.
Baroness Sayeeda Warsi, the first Muslim cabinet minister and a crossbench peer, is among its most prominent supporters, while Mishal Husain, a former BBC Radio 4 presenter and upcoming Bloomberg host, is understood to support the initiative, although she will not play a formal role.
Early discussions with the government and opposition parties are underway, and the launch event is expected to feature senior political figures.
“The British Muslim community is hyper-diverse in class, culture, background, ethnicity, religiosity, age,” Warsi told The Times. “It is such a vibrant, clever, and engaged community. But what we’ve had for nearly 17 years (is) a policy of disengagement with British Muslim communities by successive governments.”
The network will have a governing board co-chaired by a man and a woman, bringing together Muslim figures from broadcasting, the arts, sport, academia, and religious leadership. A source described it as “the most high-profile network of British Muslims that has ever existed.”
Warsi stressed the need for a group that could represent the full spectrum of British Muslims and their contributions and concerns, moving beyond what she called the government’s past focus on counter-terrorism.
“Governments have only really spoken to representatives from the UK’s Muslim communities through the prism of counter-terrorism,” she said.
Akeela Ahmed, founder of the She Speaks We Hear online platform, and who was recently honored with an MBE for services to Muslim women, emphasized the network’s focus on everyday issues. “We want to bring together expertise and insight and share this with policymakers,” she said.
The initiative has also won the backing of Brendan Cox, co-founder of the Together Coalition and widower of Jo Cox, who was murdered by a right-wing extremist in 2016.
He described it as “an incredibly influential group.”
The Right Rev. Toby Howarth, the bishop of Bradford, said: “The British Muslim Network is a much-needed voice, and I look forward to working with them.”
Trump immigration enforcement memo targets migrants who entered legally under Biden
- The US Department of Homeland Security memo provides guidance for the use of a fast-track deportation process
- The process, known as “expedited removal,” had been applied only to people apprehended within 14 days of entering the country
WASHINGTON: The Trump administration is empowering federal immigration officers to consider whether to strip temporary legal status from migrants who entered through former President Joe Biden’s signature “parole” programs in an effort to ramp up deportations to record levels, according to a memo issued on Thursday.
The US Department of Homeland Security memo provides guidance for the use of a fast-track deportation process that the Trump administration reinstated earlier this week, suggesting officers focus on migrants who failed to request asylum within a one-year deadline after arriving in the US
The process, known as “expedited removal,” had been applied only to people apprehended within 14 days of entering the country and within 100 miles (160 km) of the border under Biden. On Tuesday, it was expanded nationwide and applied to all those who entered within two years.
President Donald Trump issued a series of executive orders after returning to the White House on Monday intended to deter illegal immigration and position the US to deport millions of immigrants without legal status.
The Republican president says the moves are necessary after millions of immigrants entered the US under Biden, both crossing illegally and through Biden’s legal entry programs.
Some Democrats and advocates counter that Trump’s aggressive enforcement could target non-criminals, disrupt businesses and split apart families. Immigrant rights group Make the Road New York sued on Wednesday to block Trump’s expansion of the fast-track deportation process.
Some 1.5 million migrants entered the US from 2022 to 2024 through two Biden legal entry “parole” programs aimed at reducing illegal crossings, according to US government statistics. One program allowed migrants waiting in Mexico to schedule an appointment to request asylum at a legal border crossing. Another allowed Cubans, Haitians, Nicaraguans and Venezuelans outside the US to enter by air if they had US sponsors and underwent vetting.
Trump ended those programs on Monday, leaving some migrants in Mexico
stranded and unsure of next steps. Migrants who might have entered legally could face riskier routes if they cross illegally and higher prices from smugglers.
The latest guidance allowing US Immigration and Customs Enforcement (ICE) officers to consider stripping active parole from people who entered in the past two years could face legal challenges, one former Biden official said.
ICE made some 500 arrests on Thursday, Fox News reported, about a third of which were people without criminal records. The agency’s daily average for arrests was 311 in fiscal year 2024 and 467 in fiscal year 2023.
Ras Baraka, the Democratic mayor of Newark, New Jersey, criticized ICE last night
for an enforcement action in his city that involved detaining US citizens and a military veteran.
University students lead a strike in Serbia as populist president plans a rally to counter protests
- Daily traffic blockades took place on Friday in various cities and towns in the Balkan nation
- “Let’s take freedom in our hands,” students told the citizens in their strike call
BELGRADE: A student-led strike closed down numerous businesses and drew tens of thousands into the streets throughout Serbia on Friday as populist President Aleksandar Vucic planned a big rally to counter persistent anti-government protests that have challenged his tight grip on power.
Daily traffic blockades took place on Friday in various cities and towns in the Balkan nation, held to commemorate the victims of a deadly canopy collapse which killed 15 people in November. Huge crowds later flooded the streets for noisy protest marches through the capital Belgrade and elsewhere in the country.
“Let’s take freedom in our hands,” students told the citizens in their strike call.
Many in Serbia believe the huge concrete canopy at a train station in the northern city of Novi Sad fell down because of sloppy reconstruction work that resulted from corruption.
Weeks-long protests demanding accountability over the crash have been the biggest since Vucic came to power more than a decade ago. He has faced accusations of curbing democratic freedoms despite formally seeking European Union membership for Serbia.
It was not immediately possible to determine how many people and companies joined the students’ call for a one-day general strike on Friday. They included restaurants, bars, theaters, bakeries, various shops and bookstores.
Vucic will gather his supporters in the central town of Jagodina later on Friday. He has announced plans to form a nationwide political movement in the style of Russia’s President Vladimir Putin that would help ensure the dominance of his right-wing Serbian Progressive Party.
The president and his mainstream media have accused the students of working under orders from foreign intelligence services to overthrow the authorities while pro-government thugs have repeatedly attacked protesting citizens.
No incidents were reported during the 15-minute traffic blockades on Friday that started at 11.52, the exact time of the canopy collapse in Novi Sad.
During a blockade last week in Belgrade, a car rammed into protesting students, seriously injuring a young woman.
Serbian universities have been blockaded for two months, along with many schools. A lawyers’ association also has gone on strike but it remained unclear how many people stayed away from work in the state-run institutions on Friday.
As well as Belgrade and Novi Sad, protest marches were also held Friday in the southern city of Nis and smaller cities, and even in Jagodina ahead of Vucic’s arrival.
“Things can’t stay the same anymore,” actor Goran Susljik told N1 regional television. “Students have offered us a possibility for a change.”
Serbia’s prosecutors have filed charges against 13 people for the canopy collapse, including a government minister and several state officials. But the former construction minister Goran Vesic has been released from detention, fueling doubts over the probe’s independence.
The main railway station in Novi Sad was renovated twice in recent years as part of a wider infrastructure deal with Chinese state companies.
Ukraine to evacuate more children from frontline villages
- “I have decided to start a mandatory evacuation of families with children” from around two dozen frontline villages and settlements, Donetsk region governor Vadym Filashkin said
- Around 110 children lived in the area affected
KYIV: Ukraine on Friday announced the mandatory evacuation of dozens of families with children from frontline villages in the eastern Donetsk region.
Russia’s troops have been grinding across the region in recent months, capturing a string of settlements, most of them completely destroyed in the fighting since Russia invaded in February 2022.
“I have decided to start a mandatory evacuation of families with children” from around two dozen frontline villages and settlements, Donetsk region governor Vadym Filashkin said on Telegram.
Around 110 children lived in the area affected, he added.
“Children should live in peace and tranquility, not hide from shelling,” he said, urging parents to heed the order to leave.
The area is in the west of the Donetsk region, close to the internal border with Ukraine’s Dnipropretovsk region.
Russia in 2022 claimed to have annexed the Donetsk region, but has not asserted a formal claim to Dnipropretovsk.
The order to leave comes a day after officials in the northeastern Kharkiv region announced the evacuation of 267 children from several settlements there under threat of Russian attack.
Trump to visit disaster zones in North Carolina, California on first trip of second term
- The president is also heading to hurricane-battered western North Carolina
WASHINGTON: President Donald Trump is heading into the fifth day of his second term in office, striving to remake the traditional boundaries of Washington by asserting unprecedented executive power.
The president is also heading to hurricane-battered western North Carolina and wildfire-ravaged Los Angeles, using the first trip of his second administration to tour areas where politics has clouded the response to deadly disasters.
