DUBAI: Iran fired a new wave of missile attacks on Israel early Monday, triggering air raid sirens across the country as emergency services reported at least five killed and dozens more wounded in the fourth day of open warfare between the regional foes that showed no sign of slowing.

Iran announced it had launched some 100 missiles and vowed further retaliation for Israel’s sweeping attacks on its military and nuclear infrastructure, which have killed at least 224 people in the country since last Friday.

The attacks raised Israel’s total death toll to at least 18, and in response the Israeli military said fighter jets had struck 10 command centers in Tehran belonging to Iran’s Quds Force, an elite arm of its Revolutionary Guard that conducts military and intelligence operations outside Iran.

Powerful explosions, likely from Israel’s defense systems intercepting Iranian missiles, rocked Tel Aviv shortly before dawn on Monday, sending plumes of black smoke into the sky over the coastal city.

Authorities in the central Israeli city of Petah Tikva said Iranian missiles had hit a residential building there, charring concrete walls, shattering windows and ripping the walls off multiple apartments.

The Israeli Magen David Adom emergency service reported that two women and two men — all in their 70s — were killed in the wave of missile attacks that struck four sites in central Israel.

“We clearly see that our civilians are being targeted,” said Israeli police spokesman Dean Elsdunne outside the bombed-out building in Petah Tikva. “And this is just one scene, we have other sites like this near the coast, in the south.”

The MDA added that paramedics had evacuated another 87 wounded people to hospitals, including a 30-year-old woman in serious condition, while rescuers were still searching for residents trapped beneath the rubble of their homes.

‘It’s terrifying’: Israeli citizens describe the moment the Iranian missiles hit

Guydo Tetelbaun was in his apartment in Tel Aviv when the alerts came in shortly after 4 a.m. (0100 GMT).

“As usual, we went into the (shelter) that’s right across the street there. And within minutes, the door of the (shelter) blew in,” the 31-year-old chef said.

“A couple of people came in bloody, all cut up. And then when we came to the apartment, after it quietened down, we saw there wasn’t much of it... Walls are caved in, no more glass,” he added.

“It’s terrifying because it’s so unknown. This could be the beginning of a long time like this, or it could get worse, or hopefully better, but it’s the unknown that’s the scariest.”

The pre-dawn missiles also struck near Shuk HaCarmel, a popular market in Tel Aviv that typically draws large crowds buying fresh fruit and vegetables. A residential street in nearby Petah Tikva and a school in ultra-Orthodox Jewish city Bnei Brak were also hit.

Iran’s Revolutionary Guards said the latest attack employed a new method that caused Israel’s multi-layered defense systems to target each other and allowed Tehran to successfully hit many targets, without providing further details.

The Israeli Defense Force did not immediately respond to a request for comment on the strikes. There were no reports in Israel of interceptor missiles hitting each other. Israeli officials have repeatedly said its defense systems are not 100 percent and have warned of tough days ahead.

Israeli Defense Minister Israel Katz said in a statement: “The arrogant dictator of Tehran has become a cowardly murderer who targets the civilian home front in Israel to deter the IDF from continuing the attack that is collapsing his capabilities.”

“The residents of Tehran will pay the price, and soon.”

Katz later issued a separate statement saying that Israel had no intention of deliberately harming Tehran’s residents.

Iranian Parliament pens plan to leave Nuclear Non-Proliferation Treaty

Iran said Monday its parliament was preparing a bill to leave the Nuclear Non-Proliferation Treaty (NPT), adding that Tehran remains opposed to developing weapons of mass destruction. Passing the bill could take several weeks.

Israel is presumed to have a sizable nuclear arsenal but neither confirms nor denies it. It is the only Middle East state that has not signed the NPT.

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Democratic senator introduces legislation to prevent Trump from using military force against Iran without permission

A Democratic senator introduced legislation on Monday to prevent US President Donald Trump from using military force against Iran without Congress’s authorization, as an escalating battle between Israel and Iran raised fears of broader conflict.

Tim Kaine of Virginia has tried for years to wrest back Congress’s authority to declare war from the White House.

During Trump’s first term, in 2020, Kaine introduced a similar resolution to rein in Trump’s ability to wage war against Iran. That measure passed both the Senate and House of Representatives, winning some Republican support, but did not garner enough votes to survive the Republican president’s veto.

Kaine said his latest war powers resolution underscores that the US Constitution gives Congress, not the president, the sole power to declare war and requires that any hostility with Iran be explicitly authorized by a declaration of war or specific authorization for the use of military force.

“It is not in our national security interest to get into a war with Iran unless that war is absolutely necessary to defend the United States. I am deeply concerned that the recent escalation of hostilities between Israel and Iran could quickly pull the United States into another endless conflict,” Kaine said in a statement.

Russia ready to mediate on Iran, and to accept Tehran’s uranium, Kremlin says

Russia remains ready to act as a mediator in the conflict between Israel and Iran, and Moscow’s previous proposal to store Iranian uranium in Russia remains on the table, the Kremlin said on Monday.

Tehran says it has the right to peaceful nuclear power, but its swiftly-advancing uranium enrichment programme has raised fears in the wider West and across the Gulf that it wants to develop a nuclear weapon.

“This proposal remains on the table, it remains relevant. But, of course, with the outbreak of hostilities, the situation has become seriously complicated,” Kremlin spokesman Dmitry Peskov said.

U.S. President Donald Trump expressed optimism on Sunday that peace would come soon and cited the possibility that Russian President Vladimir Putin could help.

Iran tells Qatar, Oman it won't negotiate ceasefire with US while under Israeli attack

Israel and Iran launched fresh attacks on Sunday, killing and wounding civilians and raising concerns of a broader regional conflict, with both militaries urging civilians on the opposing side to take precautions against further strikes. 

Israel warned that the worse is to come. It targeted Iran's Defense Ministry headquarters in Tehran and sites it alleged were associated with Iran's nuclear program, while Iranian missiles evaded Israeli air defenses and slammed into buildings deep inside Israel.

An Iranian health ministry spokesperson, Hossein Kermanpour, said the toll since the start of Israeli strikes had risen to 224 dead and more than 1,200 injured, 90 percent of whom he said were civilians. Those killed included 60 on Saturday, half of them children, in a 14-story apartment block flattened in the Iranian capital.

German Chancellor Friedrich Merz said he hoped a meeting of the Group of Seven leaders in Canada on Sunday would reach an agreement to help resolve the conflict and keep it from escalating.

Iran has told mediators Qatar and Oman that it is not open to negotiating a ceasefire with the US while it is under Israeli attack, an official briefed on the communications told Reuters on Sunday. The Israeli military, which launched the attacks on Friday with the stated aim of wiping out Iran’s nuclear and ballistic missile programs, warned Iranians living near weapons facilities to evacuate.