LONDON/CHICAGO: Scientists studying the new mpox strain that has spread out of Democratic Republic of Congo say the virus is changing faster than expected and often in areas where experts lack the funding and equipment to properly track it.
That means there are multiple unknowns about the virus itself, its severity and how it is transmitting, complicating the response, half a dozen scientists in Africa, Europe and the United States told Reuters.
Mpox, formerly known as monkeypox, has been a public health problem in parts of Africa since 1970, but received little global attention until it surged internationally in 2022, prompting the World Health Organization to declare a global health emergency. That declaration ended 10 months later.
A new strain of the virus, known as clade Ib, has the world’s attention again after the WHO declared a new health emergency.
The strain is a mutated version of clade I, a form of mpox spread by contact with infected animals that has been endemic in Congo for decades. Mpox typically causes flu-like symptoms and pus-filled lesions and can kill.
Congo has had more than 18,000 suspected clade I and clade Ib mpox cases and 615 deaths this year, according to the WHO. There have also been 222 confirmed clade Ib cases in four African countries in the last month, plus a case each in Sweden and Thailand in people with a travel history in Africa.
“I worry that in Africa, we are working blindly,” said Dr. Dimie Ogoina, an infectious diseases expert at Niger Delta University Hospital in Nigeria who chairs the WHO’s mpox emergency committee. He first raised the alarm about potential sexual transmission of mpox in 2017, now an accepted route of spread for the virus.
“We don’t understand our outbreak very well, and if we don’t understand our outbreak very well we will have difficulty addressing the problem in terms of transmission dynamics, the severity of the disease, risk factors of the disease,” Ogoina said. “And I worry about the fact that the virus seems to be mutating and producing new strains.”
He said it took clade IIb in Nigeria five years or more to evolve enough for sustained spread among humans, sparking the 2022 global outbreak. Clade Ib has done the same thing in less than a year.
Mutating ‘more rapidly’
Mpox is an orthopoxvirus, the same family that causes smallpox. Population-wide protection from a global vaccine campaign 50 years ago has waned, as the vaccinating stopped when the disease was eradicated.
Genetic sequencing of clade Ib infections, which the WHO estimates emerged mid-September 2023, show they carry a mutation known as APOBEC3, a signature of adaptation in humans.
The virus that causes mpox has typically been fairly stable and slow to mutate, but APOBEC-driven mutations can accelerate viral evolution, said Dr. Miguel Paredes, who is studying the evolution of mpox and other viruses at Fred Hutchison Cancer Center in Seattle.
“All the human-to-human cases of mpox have this APOBEC signature of mutations, which means that it’s mutating a little bit more rapidly than we would expect,” he said.
Paredes and other scientists said a response was complicated by several mpox outbreaks happening at once.
In the past, mpox was predominantly acquired through human contact with infected animals. That is still driving a rise in Congo in clade I cases – also known as clade Ia — likely due in part to deforestation and increased consumption of bushmeat, scientists said.
The mutated versions, clade Ib and IIb, can now essentially be considered a sexually transmitted disease, said Dr. Salim Abdool Karim, a South African epidemiologist and chair of the Africa CDC’s mpox advisory committee. Most of the mutated clade Ib cases are among adults, driven at first by an epidemic among female sex workers in South Kivu, Congo.
The virus also can spread through close contact with an infected person, which is likely how clusters of children have been infected with clade Ib, particularly in Burundi and in eastern Congo’s displacement camps, where crowded living conditions may be contributing.
Children, pregnant women and people with weakened immune systems may be at greater risk of serious mpox disease and death, according to the WHO.
Clade I has typically caused more severe disease, with fatality rates of 4 percent-11 percent, compared to around 1 percent for clade II. Ogoina said data from Congo suggests few have died of the new Ib version, but he feared some data is being mixed up.
More research is urgently needed, but three teams tracking mpox outbreaks in Africa say they cannot even access chemicals needed for diagnostic tests.
Planning a response, including vaccination strategies, without this is difficult, the scientists said.
Karim said around half of cases in eastern Congo, where Ib is particularly prevalent, are only being diagnosed by doctors, with no laboratory confirmation.
Getting samples to labs is difficult because the health care system is already under pressure, he said. And around 750,000 people have been displaced amid fighting between the M23 rebel group and the government.
Many African laboratories cannot get the supplies they need, said Dr. Emmanuel Nakoune, an mpox expert at the Institut Pasteur in Bangui, Central African Republic, which also has clade Ia cases.
“This is not a luxury,” he said, but necessary to track deadly outbreaks.
New mpox strain is changing fast; African scientists are ‘working blindly’ to respond
https://arab.news/j4jvt
New mpox strain is changing fast; African scientists are ‘working blindly’ to respond
- Scientists say many questions remain about new clade Ib strain
- Sexual transmission driving spread, but children infected, too
New Bangladeshi tourism initiative empowers marginalized Indigenous groups
- BRAC’s Othiti program helps uplift rural communities and their traditional skills
- Pilot program is underway in Rajshahi district near the Bangladesh–India border
DHAKA: A new initiative by Bangladesh’s largest development organization is fostering community-based tourism in remote rural areas to empower Indigenous groups and help preserve their cultures.
There are more than 50 Indigenous groups in Bangladesh, most of whom, or about 1 million people, live in the flatland districts of the country’s north and southeast, and in the Chittagong Hill Tracts, bordering India and Myanmar.
Launched in early November, the new tourism initiative spearheaded by BRAC is named Othiti, which means “guest” in Bengali.
The pilot program is underway in Rajshahi district on the northern bank of the Padma River, near the Bangladesh–India border.
“We started the journey of Othiti from Rajshahi. Tourists rarely visit this part of the country, but it is very rich, both culturally and historically. Starting from the mighty river Padma, there’s a lot of natural beauty over there,” Asif Saleh, BRAC executive director, told Arab News.
“We will not be confined within Rajshahi. There are plans to expand this tourism project in other parts of the country … in places like Sundarbans, Chottogram Hill Tracts, Cox’s Bazar. We will try to connect tourists particularly with the Indigenous communities of these areas to experience their traditions, culture, and customs. If tourists can experience the diversity of these areas, they can connect with them in a different way. It will make people prouder of the rich history and culture of our country.”
The project involves rural youth, students of the Rajshahi University, whom BRAC has employed as part-time guides to introduce visitors to their customs and traditional livelihoods.
“We have built a relationship of trust and reliability with these communities. We hope that tourists will become interested in the culture and customs of the Indigenous people, and have a better understanding and empathy towards them,” Saleh said.
“Our Othiti aims for the sector’s development as well as employment for the (local) people, which will benefit these communities … We began this project as a social enterprise. We may incur loss initially for many years, but ultimately, if the sector develops, it will attract many people.”
Indigenous communities in Bangladesh have been struggling with access to education, healthcare, and jobs. Many live in forest areas with inadequate infrastructure. Poverty and unemployment levels among these groups are much higher than among the non-Indigenous.
Moutushi Biswas, a BRAC consultant, said a number of initiatives under the Othiti program are meant to uplift the communities and their traditional skills.
For example, introducing tourists to the Premtoli village of potters helped increase demand for their earthenware and work.
“While visiting the pottery community, tourists are experiencing the craftsmanship of potters who have been engaged in this for many generations. They can experience it by themselves, making clay pots under the guidance of a traditional potter. It’s a very unique experience,” she said.
“This initiative is also strengthening the abilities of local communities … The locals who work with us are very enthusiastic about this. We are receiving huge cooperation from them.”
For Happy Soren, a 25-year-old student and Othiti guide, having tourists visit was not only strengthening the village’s economy but also helping raise awareness about her community.
“The tourists want to know our customs and religious beliefs. They want to know the reasons behind the special patterns and paintings on our houses … Our village becomes very festive when they visit us,” she said.
“We believe the tourists who experience our culture and heritage will play a role in developing our village after they go back to their own places and work. They will stand by our people.”
Top court intervenes in New Delhi pollution crisis as respiratory cases spike
- Number of patients with respiratory diseases has increased two to threefold
- Court orders Delhi authorities to set up checkpoints, prevent entry of commercial vehicles
India’s top court intervened on Friday to request policing measures in New Delhi to contain severe air pollution that over the past week has led to a surge in hospital admissions for respiratory diseases.
Residents of the Indian capital again woke to a thick layer of toxic smog, with an overall Air Quality Index reading of 373, or “very poor,” according to the Central Pollution Control Board.
While conditions have slightly improved since Monday, when a medical emergency was declared with pollution reaching the “severe plus” AQI score of 484, the prolonged crisis prompted the Supreme Court to order the central and local governments to introduce new measures to contain it.
The court said during Friday’s hearing that it was “not satisfied” with the Delhi administration and police efforts to address the pollution and ordered the authorities to “ensure that check posts are immediately set up at all 113 entry points (to the capital)” to stop trucks and commercial vehicles from entering the city.
The move follows the court’s order earlier this week to suspend all construction work in the whole of New Delhi and the National Capital Region.
“It is a constitutional obligation of the central government and the states to ensure that citizens live in a pollution-free atmosphere,” the court said.
As toxic smog has persisted for over a week, Delhi authorities have shut all schools and moved classes online, while half of the government employees have been allowed to work from home.
The continuing crisis is already reflected in a surge of hospitalizations for respiratory disease.
“The cases related to lungs and respiratory problems have significantly risen,” Dr. Nikhil Modi, pulmonologist at Indraprastha Apollo Hospital in New Delhi, told Arab News, adding that the patients coming to the hospital with respiratory issues are “two to three times the normal” amount.
“Especially for those who already have underlying lung disease, the problem can be significant, and if they develop a secondary pneumonia or an infection, then they require emergency admission,” Modi said.
Toxic smog arrives in New Delhi every winter as temperatures drop, trapping toxic pollutants from tens of millions of cars, as well as construction sites, factory emissions, and waste burning. It is aggravated by farmland fires in the country’s northwest and southeast, where farmers clear stubble to prepare fields to plant wheat.
The US Embassy in London returns to normal after police carry out controlled explosion of package
- London’s Metropolitan Police Service closed a road on the west side of the embassy
- “Local authorities investigated and cleared a suspicious package outside the Embassy,” the embassy said
LONDON: The US Embassy in London returned to normal operations Friday afternoon after police carried out the controlled explosion of a suspicious package that was found in the area earlier in the day.
London’s Metropolitan Police Service closed a road on the west side of the embassy out of an “abundance of caution” as they investigated the incident, the embassy said in a statement. The embassy said it had returned to “normal business operations” by early afternoon, although all public appointments were canceled for the day.
“Local authorities investigated and cleared a suspicious package outside the Embassy,” the embassy said. ”Thanks to @metpoliceuk for your swift action, and thanks to all visitors for your cooperation and patience at this time.”
Also Friday, authorities evacuated the south terminal of London’s Gatwick Airport while they investigated a suspicious item found in luggage. Sussex Police said they had sent an ordnance disposal team to the airport as a precaution.
A proposed deal on climate cash at UN summit highlights split between rich and poor nations
- “Our expectations were low, but this is a slap in the face,” said Mohamed Adow, from Power Shift Africa
- “No developing country will fall for this. They have angered and offended the developing world”
BAKU: A new draft of a deal on cash to curb and adapt to climate change released Friday afternoon at the United Nations climate summit pledged $250 billion by 2035 from wealthy countries to poorer ones. The amount pleases the countries who will be paying, but not those on the receiving end.
The amount is more than double the previous goal of $100 billion a year set 15 years ago, but it’s less than a quarter of the number requested by developing nations struck hardest by extreme weather. But rich nations say the number is about the limit of what they can do, say it’s realistic and a stretch for democracies back home to stomach.
It struck a sour note for developing countries, which see conferences like this one as their biggest hope to pressure rich nations because they can’t attend meetings of the world’s biggest economies.
“Our expectations were low, but this is a slap in the face,” said Mohamed Adow, from Power Shift Africa. “No developing country will fall for this. They have angered and offended the developing world.”
Nations are still far apart on reaching a deal
The proposal came down from the top, the presidency of UN climate talks — called COP29 — in Baku, Azerbaijan. Delegations from numerous countries, analysts and advocates were kept in the dark about the draft until it dropped more than a half a day later than promised, prompting grumblings about how this conference was being run.
“These texts form a balanced and streamlined package,” the Presidency said in a statement. “The COP29 Presidency urges parties to study this text intently, to pave the way toward consensus, on the few options remaining.”
This proposal, which is friendly to the viewpoint of Saudi Arabia, is not a take-it-or-leave-it option, but likely only the first of two or even three proposals, said Climate Analytics CEO Bill Hare, a veteran negotiator.
“We’re in for a long night and maybe two nights before we actually reach agreement on this,” Hare said.
Just like last year’s initial proposal, which was soundly rejected, this plan is “empty” on what climate analysts call “mitigation” or efforts to reduce emissions from or completely get off coal, oil and natural gas, Hare said.
Anger at ‘meagre’ figure for climate cash
The frustration and disappointment at the proposed $250 billion figure was palpable on Friday afternoon.
“It is a disgrace that despite full awareness of the devastating climate crises afflicting developing nations and the staggering costs of climate action — amounting to trillions — developed nations have only proposed a meagre $250 billion per year,” said Harjeet Singh of the Fossil Fuel Non-Proliferation Treaty.
That amount, which goes through the year 2035, is basically the old $100 billion year goal with 6 percent annual inflation, said Vaibhav Chaturvedi a climate policy analyst with New Delhi-based Council on Energy, Environment and Water.
Experts put the need at $1.3 trillion for developing countries to cover damages resulting from extreme weather, help those nations adapt to a warming planet and wean themselves from fossil fuels, with more generated by each country internally.
The amount in any deal reached at COP negotiations — often considered a “core” — will then be mobilized or leveraged for greater climate spending. But much of that means loans for countries drowning in debt.
Singh said the proposed sum — which includes loans and lacks a commitment to grant-based finance — adds “insult to injury.”
Iskander Erzini Vernoit, director of Moroccan climate think-tank Imal Initiative for Climate and Development, said “the EU and the US and other developed countries cannot claim to be committed to the Paris Agreement while putting forward such amounts” of money.
Countries reached the Paris Agreement in 2015, pledging to keep warming below 1.5 degrees Celsius (2.7 Fahrenheit) since pre-industrial times. The world is now at 1.3 degrees Celsius (2.3 degrees Fahrenheit), according to the UN
Rich countries call for realism
Switzerland environment minister Albert Rösti said it was important that the climate finance number is realistic.
“I think a deal with a high number that will never be realistic, that will never be paid… will be much worse than no deal,” he said.
The United States’ delegation offered a similar warning.
“It has been a significant lift over the past decade to meet the prior, smaller goal” of $100 billion, said a senior US official. “$250 billion will require even more ambition and extraordinary reach” and will need to be supported by private finance, multilateral development banks — which are large international banks funded by taxpayer dollars — and other sources of finance, the official said.
A lack of a bigger number from European nations and the US means that the “deal is clearly moving toward the direction of China playing a more prominent role in helping other global south countries,” said Li Shou of the Asia Society Policy Institute.
German delegation sources said it will be important to be in touch with China and other industrialized nations as negotiations press on into the evening.
Analysts said the proposed deal is the start of what could likely be more money.
“This can be a good down payment that will allow for good climate action in developing countries,” said Melanie Robinson, global climate program director at the World Resources Institute. “There is scope for this to go above $250 billion if contributors decides to come on board.”
Rob Moore, associate director at E3G, said that whatever figure is agreed “will need to be the start and not the end” of climate cash promises.
“If developed countries can go further they need to say so fast to make sure we get a deal at COP29,” he said.
Ukraine’s parliament cancels session after Russia fired a new missile
- Three Ukrainian lawmakers confirmed that the parliamentary session previously scheduled was canceled
- President Volodymyr Zelensky’s office continued to work in compliance with standard security measures
KYIV: Ukraine’s parliament canceled a session on Friday as security was tightened after Russia deployed a new ballistic missile that threatens to escalate the nearly three-year war.
Russian troops also struck Sumy with Shahed drones overnight killing two people and injuring 12 more, the regional administration said Friday morning. The attack targeted a residential district of the city.
Ukraine’s Suspilne media, quoting Sumy regional head Volodymyr Artiukh, said the Russians used Shaheds stuffed with shrapnel elements for the first time in the region. “These weapons are used to destroy people, not to destroy objects,” said Artiukh, according to Suspilne.
Separately, Czech Foreign Minister Jan Lipavsky arrived on a visit to Kyiv. He posted a photo from Kyiv’s railway station on his X account Friday morning.
“I am interested in how the Ukrainians are coping with the bombings, how Czech projects are working on the ground and how to better target international aid in the coming months. I will discuss all of this here,” Lipavsky wrote.
Three Ukrainian lawmakers confirmed that the parliamentary session previously scheduled was canceled due to the ongoing threat of Russian missile attacks targeting government buildings in the city center.
Not only is the parliament closed, “there was also recommendation to limit the work of all commercial offices and NGOs that remain in that perimeter, and local residents were warned of the increased threat,” said lawmaker Mykyta Poturaiev, who added this is not the first time such a threat has been received.
President Volodymyr Zelensky’s office continued to work in compliance with standard security measures, a spokesperson said.
Russia on Thursday fired a new intermediate-range ballistic missile in response to Kyiv’s use of US and British longer-range missiles capable of striking deeper into Russian territory, Russian President Vladimir Putin said in an address on Thursday.
It struck a missile factory in Dnipro in central Ukraine. Putin warned that US air defense systems would be powerless to stop the new missile, which he said flies at 10 times the speed of sound and which he called Oreshnik – Russian for hazelnut tree.
The Pentagon confirmed that Russia’s missile was a new, experimental type of intermediate-range missile based on its RS-26 Rubezh intercontinental ballistic missile.
