LONDON/CHICAGO: Scientists studying the new mpox strain that has spread out of Democratic Republic of Congo say the virus is changing faster than expected and often in areas where experts lack the funding and equipment to properly track it.
That means there are multiple unknowns about the virus itself, its severity and how it is transmitting, complicating the response, half a dozen scientists in Africa, Europe and the United States told Reuters.
Mpox, formerly known as monkeypox, has been a public health problem in parts of Africa since 1970, but received little global attention until it surged internationally in 2022, prompting the World Health Organization to declare a global health emergency. That declaration ended 10 months later.
A new strain of the virus, known as clade Ib, has the world’s attention again after the WHO declared a new health emergency.
The strain is a mutated version of clade I, a form of mpox spread by contact with infected animals that has been endemic in Congo for decades. Mpox typically causes flu-like symptoms and pus-filled lesions and can kill.
Congo has had more than 18,000 suspected clade I and clade Ib mpox cases and 615 deaths this year, according to the WHO. There have also been 222 confirmed clade Ib cases in four African countries in the last month, plus a case each in Sweden and Thailand in people with a travel history in Africa.
“I worry that in Africa, we are working blindly,” said Dr. Dimie Ogoina, an infectious diseases expert at Niger Delta University Hospital in Nigeria who chairs the WHO’s mpox emergency committee. He first raised the alarm about potential sexual transmission of mpox in 2017, now an accepted route of spread for the virus.
“We don’t understand our outbreak very well, and if we don’t understand our outbreak very well we will have difficulty addressing the problem in terms of transmission dynamics, the severity of the disease, risk factors of the disease,” Ogoina said. “And I worry about the fact that the virus seems to be mutating and producing new strains.”
He said it took clade IIb in Nigeria five years or more to evolve enough for sustained spread among humans, sparking the 2022 global outbreak. Clade Ib has done the same thing in less than a year.
Mutating ‘more rapidly’
Mpox is an orthopoxvirus, the same family that causes smallpox. Population-wide protection from a global vaccine campaign 50 years ago has waned, as the vaccinating stopped when the disease was eradicated.
Genetic sequencing of clade Ib infections, which the WHO estimates emerged mid-September 2023, show they carry a mutation known as APOBEC3, a signature of adaptation in humans.
The virus that causes mpox has typically been fairly stable and slow to mutate, but APOBEC-driven mutations can accelerate viral evolution, said Dr. Miguel Paredes, who is studying the evolution of mpox and other viruses at Fred Hutchison Cancer Center in Seattle.
“All the human-to-human cases of mpox have this APOBEC signature of mutations, which means that it’s mutating a little bit more rapidly than we would expect,” he said.
Paredes and other scientists said a response was complicated by several mpox outbreaks happening at once.
In the past, mpox was predominantly acquired through human contact with infected animals. That is still driving a rise in Congo in clade I cases – also known as clade Ia — likely due in part to deforestation and increased consumption of bushmeat, scientists said.
The mutated versions, clade Ib and IIb, can now essentially be considered a sexually transmitted disease, said Dr. Salim Abdool Karim, a South African epidemiologist and chair of the Africa CDC’s mpox advisory committee. Most of the mutated clade Ib cases are among adults, driven at first by an epidemic among female sex workers in South Kivu, Congo.
The virus also can spread through close contact with an infected person, which is likely how clusters of children have been infected with clade Ib, particularly in Burundi and in eastern Congo’s displacement camps, where crowded living conditions may be contributing.
Children, pregnant women and people with weakened immune systems may be at greater risk of serious mpox disease and death, according to the WHO.
Clade I has typically caused more severe disease, with fatality rates of 4 percent-11 percent, compared to around 1 percent for clade II. Ogoina said data from Congo suggests few have died of the new Ib version, but he feared some data is being mixed up.
More research is urgently needed, but three teams tracking mpox outbreaks in Africa say they cannot even access chemicals needed for diagnostic tests.
Planning a response, including vaccination strategies, without this is difficult, the scientists said.
Karim said around half of cases in eastern Congo, where Ib is particularly prevalent, are only being diagnosed by doctors, with no laboratory confirmation.
Getting samples to labs is difficult because the health care system is already under pressure, he said. And around 750,000 people have been displaced amid fighting between the M23 rebel group and the government.
Many African laboratories cannot get the supplies they need, said Dr. Emmanuel Nakoune, an mpox expert at the Institut Pasteur in Bangui, Central African Republic, which also has clade Ia cases.
“This is not a luxury,” he said, but necessary to track deadly outbreaks.
New mpox strain is changing fast; African scientists are ‘working blindly’ to respond
https://arab.news/j4jvt
New mpox strain is changing fast; African scientists are ‘working blindly’ to respond
- Scientists say many questions remain about new clade Ib strain
- Sexual transmission driving spread, but children infected, too
Putin says Slovakia offered to host Ukraine peace talks
MOSCOW: Russian President Vladimir Putin said Thursday that Slovakia had offered to be a “platform” for possible peace talks between Russia and Ukraine, nearly three years since the launch of Moscow’s offensive.
Putin told a televised press conference Slovakia’s Prime Minister Robert Fico “said that if there are any negotiations, they would be happy to provide their country as a platform.”
He added that Russia was “not against it,” praising Slovakia’s “neutral position.”
Fico, one of the few European leaders to maintain ties with the Kremlin, met with the Russian president in Moscow on December 22.
His visit came despite Western efforts to isolate Putin and present a united front in support for Kyiv.
Slovakia, an EU and NATO member, has already halted military aid to Ukraine since autumn 2023 under Fico’s government, and called for peace talks.
Fico has accused Kyiv of jeopardizing his country’s supply of Russian natural gas, on which it is heavily dependent.
Ukraine has said it will not renew a contract expiring at the end of this year to allow Russia gas to transit its country toward Europe, and no feasible alternative has yet been found.
Ukrainians “are already punishing Europe by ending the contract to supply our gas,” Putin said, adding that no new contract could be reached “in three or four days.”
But he suggested he was ready to supply gas to the EU, possibly via the Yamal-Europe pipeline that transits Poland.
The prospect of peace talks to end the conflict in Ukraine that began in February 2022 has grown since the re-election of Donald Trump to the White House.
Trump has vowed to push for a quick deal to halt the fighting when he takes office in January.
That has sparked fears in Kyiv and Europe that Ukraine could be pushed to make concessions to Moscow.
Putin reiterated his vow that his country would achieve “all the objectives in Ukraine.”
“This is our number one task,” he said, warning that Moscow was ready to again use its latest-generation Oreshnik missile, first fired in a strike last month.
Putin has repeatedly threatened to strike “decision-making centers” in Kyiv in retaliation for its use of Western-supplied long-range missiles to hit targets in Russia.
He also claimed Thursday that in 2021, US President Joe Biden offered to “push back” Ukraine’s entry into NATO — a move urgently sought by Kyiv but that Putin considers an unacceptable threat.
“In 2021, the current President Biden offered exactly that: push back Ukraine’s NATO membership by 10 to 15 years, because it was not yet ready.”
“I answered reasonably that ‘Yes, today it is not ready. But you will prepare it for it and you will accept it.’“
But for Russia, “What is the difference — today, tomorrow or in 10 years?“
US says kills two Al-Shabab fighters in airstrike
WASHINGTON: The US military said Thursday it had killed two members of the jihadist Al-Shabab group in southern Somalia in an airstrike.
The strike took place on Tuesday about 10 kilometers (six miles) southwest of the town of Quyno Barrow, south of Mogadishu, the United States Africa Command (US AFRICOM) said in a statement.
The strike was conducted “in coordination” with Somalia’s federal government, it said.
“The command will continue to assess the results of the operation and provide additional information as appropriate,” the statement said, providing no further details.
The Somalian government issued a statement lauding a “meticulously planned operation” that was conducted alongside “international partners” in the same district.
That statement said the operation “has successfully eliminated the terrorist ring leader Mohamed Mire Jama, also known as Abu Abdirahman, in the Kunyo-Barow district of Lower Shabelle province.”
Somalia is one of the poorest countries on the planet, enduring decades of civil war, a bloody insurgency by the Al-Qaeda-linked Al-Shabab, and frequent climate disasters.
Washington has invested massively for several decades in the fight against the insurgency.
During his first term, US President-elect Donald Trump announced the withdrawal of US troops from Somalia, a decision reversed by his successor Joe Biden.
Earlier this week, Egypt said it was joining a new African Union peacekeeping force in Somalia.
The mandate of the current African Union Transition Mission in Somalia (ATMIS) ends on December 31, and it will make way for a new force against the Al-Shabab insurgents, the African Union Support and Stabilization Mission in Somalia (AUSSOM).
India’s former PM Manmohan Singh dies aged 92
- Singh became a vocal critic of Modi’s economic policies, and more recently warned about the risks that rising communal tensions posed to India’s democracy
NEW DELHI: Manmohan Singh, the former Indian prime minister whose economic reforms made his country a global powerhouse, has died at the age of 92, current leader Narendra Modi said Thursday.
India “mourns the loss of one of its most distinguished leaders,” Modi posted on social media platform X shortly after news broke of Singh’s passing.
“As our Prime Minister, he made extensive efforts to improve people’s lives.”
Singh was taken to a hospital in New Delhi after he lost consciousness at his home on Thursday, but could not be resuscitated and was pronounced dead at 9:51 p.m. local time, according to a statement by the All India Institute of Medical Sciences.
Singh, who held office from 2004 to 2014, is credited with having overseen an economic boom in Asia’s fourth-largest economy in his first term, although slowing growth in later years marred his second stint.
“I have lost a mentor and guide,” opposition Congress leader Rahul Gandhi said in a statement, adding that Singh had “led India with immense wisdom and integrity.”
“Millions of us who admired him will remember him with the utmost pride,” said Gandhi, a scion of India’s powerful Nehru-Gandhi dynasty and the most prominent challenger to Modi.
Mallikarjun Kharge, leader of the opposition in parliament’s upper house, said “India has lost a visionary statesman, a leader of unimpeachable integrity, and an economist of unparalleled stature.”
President Droupadi Murmu wrote on X that Singh will “always be remembered for his service to the nation, his unblemished political life and his utmost humility.”
Born in 1932 in the mud-house village of Gah in what is now Pakistan, Singh studied economics to find a way to eradicate poverty in India and never held elected office before taking the vast nation’s top job.
He won scholarships to attend both Cambridge, where he obtained a first in economics, and Oxford, where he completed his PhD.
Singh worked in a string of senior civil posts, served as a central bank governor and also held various jobs with global agencies including the United Nations.
He was tapped in 1991 by then Congress prime minister P.V. Narasimha Rao to reel India back from the worst financial crisis in its modern history.
In his first term Singh steered the economy through a period of nine-percent growth, lending India the international clout it had long sought.
He also sealed a landmark nuclear deal with the United States that he said would help India meet its growing energy needs.
Known as “Mr Clean,” Singh nonetheless saw his image tarnished during his decade-long tenure when a series of corruption cases became public.
Several months before the 2014 elections, Singh said he would retire after the polls, with Sonia Gandhi’s son Rahul earmarked to take his place if Congress won.
But Congress crashed to its worst-ever result at that time as the Hindu-nationalist Bharatiya Janata Party, led by Modi, won in a landslide.
Singh — who said historians would be kinder to him than contemporary detractors — became a vocal critic of Modi’s economic policies, and more recently warned about the risks that rising communal tensions posed to India’s democracy.
Russia missile suspected in Azerbaijani plane crash, Moscow warns against ‘hypotheses’
- Pro-government Azerbaijani website Caliber cited officials as saying they believed a Russian missile fired from a Pantsir-S air defense system downed the plane
ASTANA: Azerbaijani and US officials believe a Russian surface-to-air missile caused the deadly crash of an Azerbaijani passenger jet, media reports and a US official said Thursday, as the Kremlin cautioned against “hypotheses” over the disaster.
The Azerbaijan Airlines jet crashed near the Kazakh city of Aktau, an oil and gas hub, on Wednesday after going off course for undetermined reasons.
Thirty-eight of the 67 people on board died.
The Embraer 190 aircraft was supposed to fly northwest from the Azerbaijani capital Baku to the city of Grozny in Chechnya, southern Russia, but instead diverted far off course across the Caspian Sea.
An investigation is underway, with pro-government Azerbaijani website Caliber citing unnamed officials as saying they believed a Russian missile fired from a Pantsir-S air defense system downed the plane.
The claim was also reported by The New York Times, broadcaster Euronews and the Turkish news agency Anadolu.
Some aviation and military experts said the plane might have been accidentally shot by Russian air defense systems because it was flying in an area where Ukrainian drone activity had been reported.
A former expert at France’s BEA air accident investigation agency said there appeared to be “a lot of shrapnel” damage on the wreckage.
Speaking on condition of anonymity, he said the damage was “reminiscent” of Malaysia Airlines flight MH17, which was downed with a surface-to-air missile by Russia-backed rebels over eastern Ukraine in 2014.
Kremlin spokesman Dmitry Peskov told reporters: “It would be wrong to make any hypotheses before the investigation’s conclusions.”
Euronews cited Azerbaijani government sources as saying that “shrapnel hit the passengers and cabin crew as it exploded next to the aircraft mid-flight.”
A US official, speaking on condition of anonymity, also said early indications suggested a Russian anti-aircraft system struck the plane.
Kazakhstan news agency Kazinform cited a regional prosecutor as saying that two black-box flight recorders had been recovered.
Azerbaijan Airlines initially said the plane flew through a flock of birds, before withdrawing the statement.
Kazakh officials said 38 people had been killed and there were 29 survivors, including three children.
Jalil Aliyev, the father of flight attendant Hokume Aliyeva, told AFP that this was supposed to have been her last flight before starting a job as a lawyer for the airline.
“Why did her young life have to end so tragically?” the man said in a trembling voice before hanging up the phone.
Eleven of the injured are in intensive care, the Kazakh health ministry said.
Azerbaijani President Ilham Aliyev declared Thursday a day of mourning and canceled a planned visit to Russia for an informal summit of the Commonwealth of Independent States (CIS), a grouping of former Soviet nations.
“I extend my condolences to the families of those who lost their lives in the crash... and wish a speedy recovery to the injured,” Aliyev said in a social media post Wednesday.
The Flight Radar website showed the plane deviating from its normal route, crossing the Caspian Sea and then circling over the area where it eventually crashed near Aktau, on the eastern shore of the sea.
Kazakhstan said the plane was carrying 37 Azerbaijani passengers, six Kazakhs, three Kyrgyz and 16 Russians.
A Kazakh woman told the local branch of Radio Free Europe/Radio Liberty (RFE/RL) she was near where the plane crashed and rushed to the site to help survivors.
“They were covered in blood. They were crying. They were calling for help,” said the woman, who gave her name as Elmira.
She said they saved some teenagers.
“I’ll never forget their look, full of pain and despair,” said Elmira. “A girl pleaded: ‘Save my mother, my mother is back there’.”
Russian President Vladimir Putin held a phone conversation with Aliyev and “expressed his condolences in connection with the crash,” Peskov told a news conference.
Manmohan Singh, India’s reluctant prime minister, dies aged 92
- The first Sikh in office, 92-year-old Singh was being treated for age-related medical conditions
- He is credited with steering India to unprecedented economic growth, lifting millions out of poverty
NEW DELHI: Described as a “reluctant king” in his first stint as prime minister, the quietly spoken Manmohan Singh was arguably one of India’s most successful leaders.
The first Sikh in office, Singh, 92, was being treated for age-related medical conditions and died after he was brought to hospital after a sudden loss of consciousness on Thursday.
He is credited with steering India to unprecedented economic growth and lifting hundreds of millions out of dire poverty. He went on to serve a rare second term.
Prime Minister Narendra Modi said: “India mourns the loss of one of its most distinguished leaders, Dr. Manmohan Singh Ji.”
He applauded the economist-turned-politician’s body of work.
Born into a poor family in a part of British-ruled India now in Pakistan, Singh studied by candlelight to win a place at Cambridge University before heading to Oxford, earning a doctorate with a thesis on the role of exports and free trade in India’s economy.
He became a respected economist, then India’s central bank governor and a government adviser but had no apparent plans for a political career when he was suddenly tapped to become finance minister in 1991.
During that tenure to 1996, Singh was the architect of reforms that saved India’s economy from a severe balance of payments crisis, promoted deregulation and other measures that opened an insular country to the world.
Famously quoting Victor Hugo in his maiden budget speech, he said: “No power on earth can stop an idea whose time has come,” before adding: “The emergence of India as a major economic power in the world happens to be one such idea.”
Singh’s ascension to prime minister in 2004 was even more unexpected.
He was asked to take on the job by Sonia Gandhi, who led the center-left Congress party to a surprise victory. Italian by birth, she feared her ancestry would be used by Hindu-nationalist opponents to attack the government if she were to lead the country.
Riding an unprecedented period of economic growth, Singh’s government shared the spoils of the country’s new found wealth, introducing welfare schemes such as a jobs program for the rural poor.
In 2008, his government also clinched a landmark deal that permitted peaceful trade in nuclear energy with the United States for the first time in three decades, paving the way for strong relations between New Delhi and Washington.
But his efforts to further open up the Indian economy were frequently frustrated by political wrangling within his own party and demands made by coalition partners.
“HISTORY WILL BE KINDER TO ME”
And while he was widely respected by other world leaders, at home Singh always had to fend off the perception that Sonia Gandhi was the real power in the government.
The widow of former prime minister Rajiv Gandhi, whose family has dominated Indian politics since independence from Britain in 1947, she remained Congress party leader and often made key decisions.
Known for his simple lifestyle and with a reputation for honesty, Singh was not personally seen as corrupt. But he came under attack for failing to crack down on members of his government as a series of scandals erupted in his second term, triggering mass protests.
The latter years of his premiership saw India’s growth story, which he had helped engineer, wobble as global economic turbulence and slow government decision-making battered investment sentiment.
In 2012, his government was tipped into a minority after the Congress party’s biggest ally quit their coalition in protest at the entry of foreign supermarkets.
Two years later Congress was decisively swept aside by the Bharatiya Janata Party under Narendra Modi, a strongman who promised to end the economic standstill, clean up graft and bring inclusive growth to the hinterlands.
But at a press conference just months before he left office, Singh insisted he had done the best he could.
“I honestly believe that history will be kinder to me than the contemporary media or, for that matter, the opposition parties in parliament,” he said.
Singh is survived by his wife and three daughters.
