LONDON/CHICAGO: Scientists studying the new mpox strain that has spread out of Democratic Republic of Congo say the virus is changing faster than expected and often in areas where experts lack the funding and equipment to properly track it.
That means there are multiple unknowns about the virus itself, its severity and how it is transmitting, complicating the response, half a dozen scientists in Africa, Europe and the United States told Reuters.
Mpox, formerly known as monkeypox, has been a public health problem in parts of Africa since 1970, but received little global attention until it surged internationally in 2022, prompting the World Health Organization to declare a global health emergency. That declaration ended 10 months later.
A new strain of the virus, known as clade Ib, has the world’s attention again after the WHO declared a new health emergency.
The strain is a mutated version of clade I, a form of mpox spread by contact with infected animals that has been endemic in Congo for decades. Mpox typically causes flu-like symptoms and pus-filled lesions and can kill.
Congo has had more than 18,000 suspected clade I and clade Ib mpox cases and 615 deaths this year, according to the WHO. There have also been 222 confirmed clade Ib cases in four African countries in the last month, plus a case each in Sweden and Thailand in people with a travel history in Africa.
“I worry that in Africa, we are working blindly,” said Dr. Dimie Ogoina, an infectious diseases expert at Niger Delta University Hospital in Nigeria who chairs the WHO’s mpox emergency committee. He first raised the alarm about potential sexual transmission of mpox in 2017, now an accepted route of spread for the virus.
“We don’t understand our outbreak very well, and if we don’t understand our outbreak very well we will have difficulty addressing the problem in terms of transmission dynamics, the severity of the disease, risk factors of the disease,” Ogoina said. “And I worry about the fact that the virus seems to be mutating and producing new strains.”
He said it took clade IIb in Nigeria five years or more to evolve enough for sustained spread among humans, sparking the 2022 global outbreak. Clade Ib has done the same thing in less than a year.
Mutating ‘more rapidly’
Mpox is an orthopoxvirus, the same family that causes smallpox. Population-wide protection from a global vaccine campaign 50 years ago has waned, as the vaccinating stopped when the disease was eradicated.
Genetic sequencing of clade Ib infections, which the WHO estimates emerged mid-September 2023, show they carry a mutation known as APOBEC3, a signature of adaptation in humans.
The virus that causes mpox has typically been fairly stable and slow to mutate, but APOBEC-driven mutations can accelerate viral evolution, said Dr. Miguel Paredes, who is studying the evolution of mpox and other viruses at Fred Hutchison Cancer Center in Seattle.
“All the human-to-human cases of mpox have this APOBEC signature of mutations, which means that it’s mutating a little bit more rapidly than we would expect,” he said.
Paredes and other scientists said a response was complicated by several mpox outbreaks happening at once.
In the past, mpox was predominantly acquired through human contact with infected animals. That is still driving a rise in Congo in clade I cases – also known as clade Ia — likely due in part to deforestation and increased consumption of bushmeat, scientists said.
The mutated versions, clade Ib and IIb, can now essentially be considered a sexually transmitted disease, said Dr. Salim Abdool Karim, a South African epidemiologist and chair of the Africa CDC’s mpox advisory committee. Most of the mutated clade Ib cases are among adults, driven at first by an epidemic among female sex workers in South Kivu, Congo.
The virus also can spread through close contact with an infected person, which is likely how clusters of children have been infected with clade Ib, particularly in Burundi and in eastern Congo’s displacement camps, where crowded living conditions may be contributing.
Children, pregnant women and people with weakened immune systems may be at greater risk of serious mpox disease and death, according to the WHO.
Clade I has typically caused more severe disease, with fatality rates of 4 percent-11 percent, compared to around 1 percent for clade II. Ogoina said data from Congo suggests few have died of the new Ib version, but he feared some data is being mixed up.
More research is urgently needed, but three teams tracking mpox outbreaks in Africa say they cannot even access chemicals needed for diagnostic tests.
Planning a response, including vaccination strategies, without this is difficult, the scientists said.
Karim said around half of cases in eastern Congo, where Ib is particularly prevalent, are only being diagnosed by doctors, with no laboratory confirmation.
Getting samples to labs is difficult because the health care system is already under pressure, he said. And around 750,000 people have been displaced amid fighting between the M23 rebel group and the government.
Many African laboratories cannot get the supplies they need, said Dr. Emmanuel Nakoune, an mpox expert at the Institut Pasteur in Bangui, Central African Republic, which also has clade Ia cases.
“This is not a luxury,” he said, but necessary to track deadly outbreaks.
New mpox strain is changing fast; African scientists are ‘working blindly’ to respond
https://arab.news/j4jvt
New mpox strain is changing fast; African scientists are ‘working blindly’ to respond
- Scientists say many questions remain about new clade Ib strain
- Sexual transmission driving spread, but children infected, too
Ukraine’s prime minister Shmyhal resigns
KYIV: Ukrainian Prime Minister Denys Shmyhal said on Tuesday he had filed a resignation letter, as a part of a major governmental reshuffle expected this week.
President Volodymyr Zelensky on Monday nominated First Deputy Prime Minister Yulia Svyrydenko for the post.
Philippines to strengthen migrant workers’ protection in labor deal with Oman
- Philippines, Oman plan to sign new MoU on labor cooperation in January
- Muscat also wants to boost ties beyond labor, explore business opportunities
MANILA: The Philippines is strengthening labor cooperation with Oman to protect the rights and welfare of Filipino workers, its Department of Migrant Workers said following a meeting with the Omani labor minister in Manila.
The majority of over 2 million overseas Filipinos live and work in Gulf countries.
While most are based in Saudi Arabia and the UAE, some 50,000 are in Oman, contributing over $340 million in annual remittance inflows to the Philippines.
Oman’s Foreign Minister Sayyid Badr Al-Busaidi and Labor Minister Mahad bin Said Ba’awin were in the Philippines earlier this week to discuss ways to further relations.
In a meeting with Philippine Migrant Workers Secretary Hans Leo Cacdac on Monday, they held talks over a new agreement on labor cooperation.
“A key highlight of the meeting was the pending Memorandum of Understanding (MOU) on Labor Cooperation, set to be signed by January 2026,” the department said in a statement.
“The MOU establishes safeguards for Filipino workers through ethical recruitment standards, fair employment terms, joint dispute resolution mechanisms, and regular monitoring through a bilateral Joint Committee.”
According to the DMW, Oman is “actively seeking Filipino domestic workers technicians, port staff, and other skilled professionals,” which could mean new employment pathways for Filipino migrant workers who are qualified.
The Philippines is also seeking to incorporate technology to streamline recruitment and deployment of overseas Filipino workers to Oman.
“By forging digital partnerships with host countries like Oman, we can make recruitment faster, more transparent, and more worker-friendly. Tech solutions can ensure every step is secure, accountable, and focused on protecting OFWs,” Cacdac said.
While labor relations have been a key aspect of Philippine-Omani ties, the Gulf state is now seeking to also explore business and investment opportunities with Manila.
“For many decades, Oman has been a popular destination for overseas Filipino workers, who have found not just employment but a second home in our country,” Al-Busaidi said at the inaugural Oman-Cebu Investment Forum over the weekend.
“Beyond the labor relations that have long defined our relations, we now open our arms to the business communities and investors of both our nations.”
A “new chapter” of Philippine-Oman relations is possible thanks to the connections created by Filipino migrant workers, he added, while urging Philippine and Omani businesses to collaborate.
“Together, we can craft a future where the thousands of people to people connections created by the overseas Filipino workers can serve as a foundation for a flourishing economic partnership, and a new era of mutual investment,” Al-Busaidi said.
“I invite you all to seize this opportunity and make it a beautiful and rewarding new chapter in the story of Oman and the Philippines.”
UK says thousands of Afghans brought to Britain under secret resettlement program
- The government now plans to close the secret route
- About 36,000 more Afghans have been relocated to the UK under other resettlement routes
LONDON: Thousands of Afghans including many who worked with British forces have been secretly resettled in the UK after a leak of data on their identities raised fears that they could be targeted by the Taliban, the British government revealed Tuesday.
The government now plans to close the secret route.
Defense Secretary John Healey said a dataset containing the personal information of nearly 19,000 Afghans who had applied to come to Britain after the Taliban takeover of Afghanistan was released in error in 2022, and extracts were later published online.
That prompted the then-Conservative government to set up a secret program to resettle the Afghans. The government obtained a court order known as a superinjunction that barred anyone from revealing its existence.
The injunction was lifted on Tuesday in conjunction with a decision by Britain’s current Labour Party government to make the program public. It said an independent review had found little evidence that the leaked data would expose Afghans to greater risk of retribution from the Taliban.
“I have felt deeply concerned about the lack of transparency to Parliament and the public,” Healey told lawmakers in the House of Commons.
About 4,500 people – 900 applicants and approximately 3,600 family members — have been brought to Britain under the secret program, and about 6,900 people are expected to be relocated by the time it closes, at a total cost of 850 million pounds ($1.1 billion).
About 36,000 more Afghans have been relocated to the UK under other resettlement routes.
British troops were sent to Afghanistan as part of a deployment against Al-Qaeda and Taliban forces in the wake of the Sept. 11, 2001, attacks. At the peak of the operation there were almost 10,000 British troops in the country, mostly in Helmand province in the south. Britain ended combat operations in 2014.
‘Existential hour’ for Palestine at 30-country conference in Colombia
- UN special rapporteur: ‘The time has come to act in pursuit of justice and peace’
- Participants will lay groundwork for implementing UNGA motion calling for end to occupation
LONDON: A 30-country conference aimed at ending Israel’s occupation of Palestine is one of the most significant political developments of the past 20 months, UN Special Rapporteur Francesca Albanese has said.
The two-day event starts on Tuesday in the Colombian capital Bogota, and will be attended by representatives from countries including China, Spain and Qatar.
Albanese will announce that the conference comes at “an existential hour,” The Guardian reported on Tuesday.
Participating countries will use the event to lay the groundwork for implementing a UN General Assembly motion calling on member states to pressure Israel into ending its illegal occupation of Palestine.
The motion included a deadline of September for putting into action the International Court of Justice’s 2024 opinion that found Israel’s occupation of Palestine to be unlawful.
The court’s advisory opinion last July called on Israel to end its occupation “as rapidly as possible.”
UN member states also have an obligation “not to render aid or assistance in maintaining the situation created by Israel’s illegal presence in the occupied Palestinian territory,” it found.
Conference host Gustavo Petro, Colombia’s president, said the meeting will demonstrate a global will to move from condemnation to collective action against Israel.
In an article for The Guardian last week, he said: “We can either stand firm in defense of the legal principles that seek to prevent war and conflict, or watch helplessly as the international system collapses under the weight of unchecked power politics.”
The Hague Group behind the conference was initially established by Colombia and South Africa, but now includes Spain, Qatar, Indonesia, Algeria and Brazil.
The group met in January at a nine-country conference and agreed to implement the ICJ’s provisional measures.
Albanese will tell the Bogota meeting: “For too long, international law has been treated as optional — applied selectively to those perceived as weak, ignored by those acting as the powerful. This double standard has eroded the very foundations of the legal order. That era must end.
“The world will remember what we, states and individuals, did in this moment — whether we recoiled in fear or rose in defense of human dignity.
“Here in Bogota, a growing number of states have the opportunity to break the silence and revert to a path of legality by finally saying: enough. Enough impunity. Enough empty rhetoric. Enough exceptionalism. Enough complicity.
“The time has come to act in pursuit of justice and peace — grounded in rights and freedoms for all, and not mere privileges for some, at the expense of the annihilation of others.”
Some airlines checking Boeing fuel switches after Air India crash
- Precautionary moves by India, South Korea and some airlines in other countries
- Some airlines around the world said they had been checking relevant switches since 2018
NEW DELHI: India on Monday ordered its airlines to examine fuel switches on several Boeing models, while South Korea said it would order a similar measure, as scrutiny intensified of fuel switch locks at the center of an investigation into a deadly Air India crash.
The precautionary moves by India, South Korea and some airlines in other countries came despite the planemaker and the US Federal Aviation Administration telling airlines and regulators in recent days that the fuel switch locks on Boeing jets are safe.
The locks have come under scrutiny following last month’s crash of an Air India jet, which killed 260 people.
A preliminary report found that the switches had almost simultaneously flipped from run position to cutoff shortly after takeoff. One pilot was heard on the cockpit voice recorder asking the other why he cut off the fuel. “The other pilot responded that he did not do so,” the report said.
The report noted a 2018 advisory from the US Federal Aviation Administration (FAA), which recommended, but did not mandate, operators of several Boeing models including the 787 to inspect the locking feature of fuel cutoff switches to ensure they could not be moved accidentally.
India’s Directorate General of Civil Aviation said it had issued an order to investigate locks on several Boeing models including 787s and 737s, after several Indian and international airlines began making their own inspections of fuel switches.
The regulator oversees the world’s third-largest and fastest-growing aviation market. Boeing planes are used by three of the country’s four largest airlines.
Precautionary checks
Some airlines around the world said they had been checking relevant switches since 2018 in accordance with the FAA advisory, including Australia’s Qantas Airways and Japan’s ANA.
Others said they had been making additional or new checks since the release of the preliminary report into the Air India crash.
Singapore Airlines said on Tuesday that precautionary checks on the fuel switches of its 787 fleet, including planes used by its low-cost subsidiary Scoot, confirmed all were functioning properly.
A spokesperson for the South Korean transport ministry said checks there would be in line with the 2018 advisory from the FAA, but did not give a timeline for them.
Flag carrier Korean Air Lines said on Tuesday it had proactively begun inspecting fuel control switches and would implement any additional requirements the transport ministry may have.
Japan Airlines said it was conducting inspections in accordance with the 2018 advisory.
Boeing referred Reuters’ questions to the FAA, which did not respond to a request for comment.
Over the weekend, Air India Group started checking the locking mechanism on the fuel switches of its 787 and 737 fleets and has discovered no problems yet, a source familiar with the matter told Reuters on Monday.
About half the group’s 787s have been inspected and nearly all its 737s, the source added, speaking on condition of anonymity. Inspections were set to be completed in the next day or two.
The Air India crash preliminary report said the airline had not carried out the FAA’s suggested inspections as the FAA’s 2018 advisory was not a mandate.
But it also said maintenance records showed that the throttle control module, which includes the fuel switches, was replaced in 2019 and 2023 on the plane involved in the crash.
In an internal memo on Monday, Air India CEO Campbell Wilson said the preliminary report found no mechanical or maintenance faults and that all required maintenance had been carried out.
