Vegas, 70, who had been battling cancer for several years, died at home Thursday, band spokesman Joe Ortiz said.
Singer/guitarist Vegas, whose real name was Lolly Vasquez, formed Redbone with his brother Patrick in 1969.
The band, with members of Latino and native American origin, released its self-titled debut album the following year. "Come and Get Your Love" peaked at No. 5 on the Billboard Hot 100 singles chart in 1974. Vegas is survived by his brother.