UK overseeing world’s largest drugs trial against COVID-19

UK medical experts are adding new and experimental treatments to the largest trial in the world titled ‘Recovery’ as soon as they become available. (AFP)
Short Url
Updated 19 April 2020
Follow

UK overseeing world’s largest drugs trial against COVID-19

  • Trial to be conducted across 165 British hospitals, with more than 5,000 patients

LONDON: The UK is overseeing the world’s largest coordinated drugs trial in a bid to find viable treatments for COVID-19. More than 5,000 patients across 165 National Health Service (NHS) hospitals — around 10 percent of all COVID-19 hospital patients in the UK — have volunteered in the past month for tests as part of the trial titled “Recovery.”
It hopes to make progress within weeks, ahead of other trials in the US and Europe, which remain in their formative stages with just a few hundred volunteers.
“Recovery” is being led by experts who previously worked on Ebola drug trials in West Africa.
Peter Horby, professor of emerging infectious diseases and global health at Oxford University, told The Guardian that the trial was unlikely to yield a “magic bullet.”
He said: “This is by far the largest trial in the world. We’re guessing some time in June we may get the results. If it is really clear that there are benefits, an answer will be available quicker.”
The trial will feature an array of treatments, including hydroxychloroquine, a drug touted as a potential cure by US President Donald Trump, and the antibiotic azithromycin.
A combination of the two has been promoted by French doctor Didier Raoult and tentatively praised by President Emmanuel Macron.
“Recovery,” though, will wait to see individual outcomes of both hydroxychloroquine and azithromycin before attempting to use the pair in conjunction.
Horby suggested that any claims the former was an effective treatment were not based on sound evidence.
“There is in-vitro evidence that it (hydroxychloroquine) is inhibitory against the virus (in a laboratory setting),” he said. “But I haven’t seen any sound clinical data.”
Other treatments set to be trialled include antiviral drugs lopinavir and ritonavir, and anti-inflammatory drug dexamethasone, used by HIV patients; the immunomodulator tocilizumab, which is used to treat rheumatoid arthritis; and convalescent plasma taken from the blood of recovered coronavirus patients.
The antiviral drug remdesivir, which was initially earmarked for use in the “Recovery” trial, will not be used as it is currently being heavily prescribed for COVID-19 patients in both China and the US.
New and experimental treatments, meanwhile, are set to be added to “Recovery” as soon as they become available.

FASTFACT

It hopes to make progress within weeks, ahead of other trials in the US and Europe, which remain in their formative stages with just a few hundred volunteers.

The trial’s co-leader Martin Landray, professor of medicine and epidemiology at the Nuffield Department of Population Health, said the speed and scale of its assembly were remarkable.
“It tells you what can happen when everybody is incentivized to make stuff happen as opposed to dither, delay,” he said.
Horby, though, was quick to lower expectations that “Recovery” would discover a cure for COVID-19 in a comparable space of time.
“I think we have to temper people’s expectations about these drugs. It’s possible some might have an effect, but it’s likely to be modest,” he said.
“I think what we’ll be looking at in terms of making a significant impact will be moving on to combinations once we know of things that work. If we combine antiviral and anti-inflammatory drugs, they might have a bigger impact,” he added.
“If you are saying this is an acute, serious viral infection, that’s really difficult to treat, you can counter that with … well, look at Ebola. That’s much nastier,” Horby said.
“Very surprisingly, the monoclonal antibodies that were trialled did work. Those are the ones we will be waiting for with a bit of bated breath to put into the trial when they become available.”


Erdogan ally floats Turkiye constitutional amendment to let him extend his tenure

Updated 05 November 2024
Follow

Erdogan ally floats Turkiye constitutional amendment to let him extend his tenure

ANKARA: The main political ally of longstanding Turkish leader Tayyip Erdogan said on Tuesday that a constitutional amendment should be considered to allow the president to run again in elections set for 2028.
After his re-election last year, Erdogan is serving his last term as president unless parliament calls an early election, according to the constitution. He has ruled Turkiye for more than 21 years, first as prime minister and then as president.
“Wouldn’t it be a natural and right choice to have our president elected once again if terror is eradicated, and if a heavy blow is dealt to inflation and Turkiye secures political and economic stability,” said Devlet Bahceli, leader of the Nationalist Movement Party (MHP), which is allied with Erdogan’s ruling AK Party (AKP).
A constitutional amendment to secure Erdogan’s ability to re-run in the presidential elections should be considered, he said in a parliamentary speech to MHP lawmakers.
Bahceli, a staunch nationalist, rattled Turkish politics last month by suggesting that the jailed leader of the outlawed Kurdistan Workers’ Party (PKK) could be allowed to speak in parliament if he announces an end to the group’s insurgency.
Some analysts said the shock suggestion might be motivated by an AKP-MHP desire to win the support of the pro-Kurdish DEM Party, parliament’s third-biggest, for a constitutional change that could boost Erdogan’s prospects in 2028 elections.
A constitutional change can be put to a referendum if 360 lawmakers in the 600-seat parliament back it. An early election also needs the support of 360 MPs.
AKP and its allies have 321 seats while DEM has 57.


A tiny village in India where Kamala Harris has ancestral roots is praying for her victory

Updated 05 November 2024
Follow

A tiny village in India where Kamala Harris has ancestral roots is praying for her victory

THULASENDRAPURAM: The temple reverberated with rhythmic Sanskrit and Tamil hymns, as a Hindu priest held a flame before the god. As this tiny South Indian village gathered to pray for Kamala Harris, a gaggle of reporters jostled for space and camera angles.
There's little to distinguish the village of Thulasendrapuram from any other rural community in Tamil Nadu, except its connection to a woman who could become America's first leader with South Asian roots.
As millions of Americans vote, Harris has people rooting for her from thousands of miles away in a village surrounded by rice paddies and coconut trees, where her mother's family has ancestral ties. They talk about her at the local tea shop. Banners and billboards bearing her face are seen throughout the community.
“Our deity is a very powerful God. If we pray well to him, he will make her victorious,” said M. Natarajan, the temple priest that led the prayers in front of the image of Hindu deity Ayyanar, a form of Lord Shiva.
Harris’ maternal grandfather was born in the village, about 350 kilometers (215 miles) from the southern coastal city of Chennai, more than 100 years ago. As an adult, he moved to Chennai, where he worked as a high-ranking government official until his retirement.
Harris has never visited Thulasendrapuram and she has no living relatives in the village, but people here still venerate the family that made it big in the U.S.
“Our village ancestors' granddaughter is running as a U.S. presidential candidate. Her victory will be happy news for every one of us,” Natarajan said.
The village's sudden fame has helped bring money into the village. Recently, construction began on a water storage tank with funds donated by a local bank. Village residents say it will carry a plaque with Harris’ name.
Harris’ late mother, Shyamala Gopalan, was born in India. After moving to the U.S. to study, she married a Jamaican man, and they named their daughter Kamala, a Sanskrit word for “lotus flower.”
Other than trips during her childhood, Harris hasn’t visited India much — particularly not since becoming vice president — but she has often spoken emotionally about her ties to her late mother’s country of birth. On Tuesday, she released a campaign video highlighting her mother, who arrived in the U.S. at age 19 and became a cancer researcher.
Titled “Mother,” the video ends with a narrator saying: “This daughter of Shyamala, this daughter of the American story, is ready to lead us forward.”
Harris has often talked about how she was guided by the values of her Indian-born grandfather and mother. She has also spoken of her love of south Indian food, especially a type of steamed rice cake called idli.
Harris’ name is engraved in a list of donors — her aunt Sarala Gopalan gave money to the temple in her name — along with that of her grandfather. Outside, a large banner wishes “the daughter of the land” success in the election.
On Tuesday, the village temple also received rare international visitors: two American tourists and one from the U.K., all wearing black t-shirts that said “Kamala Freakin Harris.”
Manikandan Ganesan, a villager who runs a small store near the temple, said Harris’ bid for the presidency has made the village famous. He hopes Harris will eventually visit them.
“Even if she mentioned that she would visit our village, it would make us very happy,” Ganesan said. “Her victory itself will be a big source of happiness for us.”
Village residents also prayed for Harris’ victory in 2020, and set off firecrackers when she became the U.S. Vice President.
For women of the village, the candidate's journey is a source of inspiration.
Local politician Arulmozhi Sudhakar said Harris embodies a significant step toward female empowerment in places like Thulasendrapuram, where a majority of women continue to face discrimination and gender inequality.
“From the time when women were not even allowed to step out of their house, to now a woman from our village contesting in the U.S. presidential election — this brings happiness for us,” Sudhakar said. “The coming generations will see her as a role model to succeed in life.”

Ukraine’s military says it shot down 48 drones and two missiles overnight

Updated 05 November 2024
Follow

Ukraine’s military says it shot down 48 drones and two missiles overnight

KYIV: The Ukrainian military said on Tuesday it shot down 48 out of 79 drones and two missiles launched by Russia overnight.
The air force said the location of 30 other drones had been lost, while another had returned to Russia.


India foreign minister says vandalism of Hindu temples deeply concerning

Updated 05 November 2024
Follow

India foreign minister says vandalism of Hindu temples deeply concerning

  • Vandalism incident happened weeks after Ottawa expelled six Indian diplomats, linking them to killing of Sikh separatist leader in 2023 
  • Canada has accused India of conducting a broad campaign against South Asian dissidents in Canada, which New Delhi denies 

SYDNEY: India foreign minister Subrahmanyam Jaishankar said on Tuesday the vandalism of a Hindu temple in Canada on Monday was deeply concerning.
“What happened yesterday at the Hindu temple in Canada was obviously deeply concerning,” he told reporters in the Australian capital Canberra while on an official visit.
The incident happened weeks after Ottawa expelled six Indian diplomats, linking them to the killing of a Sikh separatist leader in 2023 in Canada. Canada has accused the Indian government of conducting a broad campaign against South Asian dissidents in Canada, which New Delhi denies.
The incident has increased tensions between Canada and India, and between Sikh separatists and Indian diplomats.
Two Hindu temples were also vandalized in Canberra last month, which Australian Foreign Minister Penny Wong said was upsetting for members of the Indian community.
“People across Australia have a right to be safe and respected, people also have a right to peaceful protest, people have a right to express their views peacefully,” she told reporters.
“We draw a line between that and violence, incitement of hatred or vandalism,” she added.
Wong said Australia had expressed its views to India about Canada’s allegations over the targeting of Sikh separatists, and Canberra respected Canada’s judicial process. Jaishankar said it was unacceptable that Indian diplomats had been placed under surveillance by Canada.
“Canada has developed a pattern of making allegations without providing specifics,” he said.


India foreign minister says vandalism of Hindu temples deeply concerning

Updated 05 November 2024
Follow

India foreign minister says vandalism of Hindu temples deeply concerning

  • Canada has accused the Indian government of conducting a broad campaign against South Asian dissidents in Canada, which New Delhi denies

SYDNEY: India foreign minister Subrahmanyam Jaishankar said on Tuesday the vandalism of a Hindu temple in Canada on Monday was deeply concerning.
“What happened yesterday at the Hindu temple in Canada was obviously deeply concerning,” he told reporters in the Australian capital Canberra while on an official visit.
The incident happened weeks after Ottawa expelled six Indian diplomats, linking them to the killing of a Sikh separatist leader in 2023 in Canada. Canada has accused the Indian government of conducting a broad campaign against South Asian dissidents in Canada, which New Delhi denies.
The incident has increased tensions between Canada and India, and between Sikh separatists and Indian diplomats.
Two Hindu temples were also vandalized in Canberra last month, which Australian Foreign Minister Penny Wong said was upsetting for members of the Indian community.
“People across Australia have a right to be safe and respected, people also have a right to peaceful protest, people have a right to express their views peacefully,” she told reporters.
“We draw a line between that and violence, incitement of hatred or vandalism,” she added.
Wong said Australia had expressed its views to India about Canada’s allegations over the targeting of Sikh separatists, and Canberra respected Canada’s judicial process. Jaishankar said it was unacceptable that Indian diplomats had been placed under surveillance by Canada.
“Canada has developed a pattern of making allegations without providing specifics,” he said.