WASHINGTON: Remdesivir has a “clear-cut” effect in helping COVID-19 patients recover, a top US scientist who oversaw a large clinical trial into the highly-anticipated antiviral said Wednesday, hailing it as proof that a drug can block the coronavirus.
Anthony Fauci made the remarks at the White House shortly after the medicine’s maker, Gilead Sciences, revealed it had met its primary goals in the largest and most robust investigation to date.
Fauci said “the data shows that remdesivir has a clear-cut, significant, positive effect in diminishing the time to recovery,” adding that it proves “that a drug can block this virus.”
The National Institute of Allergy and Infectious Diseases, which Fauci leads, is soon expected to release a detailed summary of the results, so it remains difficult to quantify exactly how well the drug performed.
Nevertheless, it represents the first time any medication has been shown to improve outcomes against the COVID-19 illness, which has claimed more than 200,000 lives globally and brought the world economy to a grinding halt.
There had been mixed news about the intravenous antiviral in recent weeks. A summary of results posted on the website of the World Health Organization last week showed it failed in a smaller Chinese trial. The Lancet on Wednesday published the formal paper describing that experiment.
In this study of 237 patients in Wuhan, China, doctors found no positive effects of administering the drug compared with a control group of adults, except for those patients who required ventilators.
But the Chinese test had to be halted early because it could not recruit enough people to meet its initial goals, and was considered by many experts to be too small to draw reliable conclusions from.
Fauci said it was “not an adequate study.”
The US-led trial, however, which began in late February, is thus far the largest to investigate remdesivir and is technically the most robust.
According to a data sheet, its estimated enrollment was 800 patients, a portion of whom received the drug while the rest received a placebo, with the trial conducted at multiple sites across the world.
Neither the patients nor their physicians were aware of which group they belonged to, in order to eliminate unconscious bias.
Its main goal was to evaluate how long patients take to recover on versus off the drug — with three different categories of recovery: hospitalized but no longer needing oxygen; discharged from hospital but still limited in their home activities; and discharged from hospital with no limits on home activities.
Without numeric data it is hard to judge just how well patients did but Gilead’s statement indicates there was an overall improvement over the placebo.
It is a Phase 3 trial, the final stage before any medication can receive regulatory approval from the Food and Drug Administration (FDA).
Remdesivir, which previously failed in trials against Ebola, belongs to a class of drugs that act on the virus directly — as opposed to controlling the abnormal and often lethal autoimmune response it causes.
It mimics one of the four building blocks of RNA and DNA and gets absorbed into the virus’s genome, which in turn stops the pathogen from replicating.
The antimalarial drugs hydroxychloroquine and chloroquine are also being widely used against COVID-19 on a so-called “compassionate basis” pending results from large trials, with early studies decidedly mixed.
Other therapies that are being studied include collecting antibodies from COVID-19 survivors and injecting them in patients, or harvesting antibodies from genetically-engineered mice that were deliberately infected.
US says Remdesivir shows ‘clear-cut’ effect in treating coronavirus
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US says Remdesivir shows ‘clear-cut’ effect in treating coronavirus
- First time any medication has been shown to improve outcomes against the COVID-19 illness
- The US-led trial, which began in late February, is the largest to investigate remdesivir and is technically the most robust
Namibians vote to wind up chaotic polls
- Electoral authorities prolonged voting until Saturday in presidential and legislative polls
- The original election day was marred by logistical and technical failures that led to hours-long queues
WINDHOEK: Namibians voted Saturday on the last day of a controversially extended election after poll chaos and allegations of foul play.
Electoral authorities prolonged voting until Saturday in presidential and legislative polls, after the original election day — Wednesday — was marred by logistical and technical failures that led to hours-long queues, which some voters eventually abandoned.
On Saturday, hundreds of people queued up at the sole polling station in the capital Windhoek where some 2,500 voters had cast their ballots on Friday.
Sielfriedt Gowaseb, 27, managed to vote in less than 30 minutes on Saturday but was critical of the arrangements.
“They should have set up at least another polling station where the majority of Namibians live. We would have needed more venues, one in the suburbs. Most Namibians don’t live in the central business district,” he said.
Namibia’s opposition is hoping to bring an end to 34 years of rule by the South West Africa People’s Organization (SWAPO), which is facing its toughest challenge as disenchanted younger voters across the region reject traditionally dominant liberation-era parties.
SWAPO has governed Namibia since leading it to independence from apartheid South Africa in 1990, but high youth unemployment and enduring inequalities have eroded its support, with around 42 percent of the 1.5 million registered voters aged under 35.
Naita Hishoono, executive director of the Namibia Institute for Democracy, a nonpartisan NGO, echoed popular dissatisfaction.
“It would have been helpful to open more than 36 polling stations... each constituency should have at least have one polling station open to accommodate everybody. Every voter should only stay half an hour to an hour in line and the whole voting process should take no more than 15 minutes,” Hishoono said.
SWAPO’s candidate, Vice President Netumbo Nandi-Ndaitwah, 72, could become the first woman to lead the country if she is elected.
The Electoral Commission of Namibia (ECN) has admitted to failures in the organization of the vote, including a shortage of ballot papers and the overheating of electronic tablets used to register voters.
Pakistan court grants bail to journalist detained after probing protest, lawyer says
- Matiullah Jan was picked up off the street on Wednesday night while investigating claims of casualties in a protest march
- The Committee to Protect Journalists had expressed ‘grave alarm’ over Jan’s ‘abduction,’ demanding his immediate release
Matiullah Jan, a critic of military influence in Pakistani politics, was granted bail by an anti-terrorism court in the capital Islamabad in a terrorism and narcotics case, his lawyer, Imaan Mazari, said in a text message.
“He should be home by this evening,” Mazari said.
Jan was picked up off the street on Wednesday night while investigating claims of casualties in a protest march demanding the release of jailed ex-Prime Minister Imran Khan, according to a colleague and his lawyer.
The Committee to Protect Journalists had expressed “grave alarm” over Jan’s “abduction,” demanding his immediate release.
Hours before being picked up, Jan had appeared on television casting doubt over the government’s denial that live ammunition had been used when security forces dispersed the protest and that any protesters had been killed.
The government has repeatedly denied using deadly force against protesters. Police and the information ministry have not responded to request for comment on Jan’s detention.
Thousands of supporters of Khan’s Pakistan Tehreek-e-Insaf (PTI) party this week stormed Islamabad. The government said they had killed four security officers.
The PTI said hundreds of protesters had been shot, and between eight and 40 killed.
Taiwan’s Lai departs for US stopover during Pacific trip
- China considers self-governed Taiwan to be part of its territory
- Beijing opposes any international recognition of the island
TAIPEI: Taiwan President Lai Ching-te departed Saturday for a stopover on US soil as part of a week-long tour of the Pacific, which has ignited fiery threats from Beijing.
China considers self-governed Taiwan to be part of its territory and opposes any international recognition of the island and its claim to be a sovereign state.
Lai, on his first trip abroad since taking office in May, will stop over in Hawaii and the US territory of Guam as he visits Taiwan’s allies Marshall Islands, Tuvalu and Palau.
They are the only Pacific island nations among the 12 remaining allies that recognize Taiwan, after China poached others with promises of aid and investment.
In a speech shortly before take-off, Lai said the tour “ushered in a new era of values-based democracy” and he thanked the US government for “helping to make this trip a smooth one.”
Lai said he wanted to “continue to expand cooperation and deepen partnerships with our allies based on the values of democracy, peace and prosperity.”
The trip has elicited a furious response from China, which has vowed to “resolutely crush” any attempts for Taiwan independence.
China and Taiwan have been ruled separately since 1949 when Chiang Kai-shek’s nationalist forces were defeated by Mao Zedong’s communist fighters and fled to the island.
Taiwan lives under the constant threat of an invasion by China, which has refused to rule out using force to bring the island under its control.
Beijing deploys fighter jets, drones and warships around Taiwan on a near-daily basis to press its claims, with the number of sorties increasing in recent years.
Taiwanese government officials have previously stopped over on US soil during visits to the Pacific or Latin America, angering China, which has sometimes responded with military drills around the island.
Lai’s tour of the Pacific was an opportunity for him “to show those countries and the world that Taiwan matters,” said Bonnie Glaser, a Taiwan-China affairs expert at the German Marshall Fund of the United States.
“I think that the People’s Republic of China always wants to leave the impression that Taiwan is isolated and it is dependent on the PRC,” Glaser told AFP, using China’s official name.
“When Taiwan’s president travels outside Taiwan, it’s a reminder that there are countries in the world that value their diplomatic relationships with Taiwan,” she said.
“And of course, when he transits the United States, it’s a reminder, I think, to the public of Taiwan, that the United States and Taiwan have a close partnership.”
The US is Taiwan’s most important backer and biggest supplier of arms, but Washington does not have official diplomatic relations with Taipei.
Lai’s trip follows the US approving the proposed sale to Taiwan of spare parts for F-16 fighter jets and radar systems, as well as communications equipment, in deals valued at $385 million in total.
Earlier this month, Taiwan’s foreign minister Lin Chia-lung met with European Parliament members in Brussels.
It was part of a trend of more senior Taiwanese officials traveling abroad and countries publicly receiving them despite the risk of suffering retaliation from China, Glaser told AFP.
“I think there’s safety in numbers — the more countries that do something, the more that other countries are willing to do it,” Glaser said.
“There’s also greater awareness of how aggressive and assertive China has been, and so countries are willing, to some extent, to stand up to China because they don’t like China’s behavior,” she said.
“And there is recognition of Taiwan’s role in the world, especially in semiconductor chips.”
More than 100 Rohingya refugees rescued off Indonesia: UN
- Indonesia is not a signatory to the UN refugee convention and says it cannot be compelled to take in refugees from Myanmar
Banda Aceh: More than 100 Rohingya refugees including women and children have been rescued after their boat sank off the coast of Indonesia, the United Nations refugee agency said Saturday.
The mostly Muslim ethnic Rohingya are heavily persecuted in Myanmar and thousands risk their lives each year on long and dangerous sea journeys to reach Malaysia or Indonesia.
“We received a report from the East Aceh government that there are 116 refugees in total,” UNHCR’s Faisal Rahman told AFP on Saturday.
“The refugees are still on the beach right now, it has not been decided where they would be taken.”
He said the flimsy wooden boat carrying the Rohingyas was found half-submerged not far from the beach off the coast of northeastern Sumatra island.
A local fisherman, Saifudin Taher said the boat was first spotted entering East Aceh waters on Saturday morning, and a few hours later it nearly sank.
“All passengers survived, but one of them was ill and ...immediately received treatment,” Saifudin told AFP, adding the boat was only 100 meters away from the beach, and the refugees could walk easily to safety.
Rohingya arrivals in Indonesia tend to follow a cyclical pattern, slowing during the stormy months and picking back up when sea conditions calm down.
Last month, 152 Rohingya refugees were finally brought ashore after being anchored for days off the coast of South Aceh district for days while officials decided whether to let them land.
Indonesia is not a signatory to the UN refugee convention and says it cannot be compelled to take in refugees from Myanmar, calling instead on neighboring countries to share the burden and resettle Rohingya who arrives on its shores.
Many Acehnese, who have memories of decades of bloody conflict themselves, are sympathetic to the plight of their fellow Muslims.
But others say their patience has been tested, claiming the Rohingya consume scarce resources and occasionally come into conflict with locals.
In December 2023, hundreds of students forced the relocation of more than 100 Rohingya refugees, storming a community hall in Aceh where they were sheltering and vandalising their belongings.
Georgia police say 107 people arrested at pro-EU protest
- The Black Sea nation has been rocked by turmoil since the ruling Georgian Dream party claimed victory in a Oct. 26 parliamentary election
TBILISI: Georgia on Saturday said 107 people were arrested during a second day of protests sparked by the government’s decision to delay European Union membership talks amid a post-election crisis.
The Black Sea nation has been rocked by turmoil since the ruling Georgian Dream party claimed victory in a October 26 parliamentary election that the pro-EU opposition said was fraudulent.
The interior ministry said 107 people were detained for “disobedience to lawful police orders and petty hooliganism.”
“Throughout the night... protesters threw various objects, including stones, pyrotechnics, glass bottles, and metal items, at law enforcement officers,” it said, adding that “10 employees of the ministry of internal affairs were injured.”
It had said that 32 police officers were wounded and 43 protesters detained on Thursday.
Prime Minister Irakli Kobakhidze’s statement Thursday that Georgia will not seek to open accession talks with the European Union until 2028 ignited a furious reaction from the opposition and two days of protests.
He later accused the opposition and the EU ambassador to Georgia of distorting his words, and insisted membership in the bloc “by 2030” remains his “top priority.”
On Friday, AFP reporters saw riot police fire water cannon and tear gas at pro-EU protesters gathered outside the parliament in Tbilisi who tossed eggs and fireworks.
Clashes broke out later between protesters and police, who moved in to clear the area outside parliament, beating demonstrators, some of whom threw objects.
Independent TV station Pirveli said one of its journalists covering the protest was hospitalized with serious injuries.
Protests were also held in other cities across Georgia on Friday, independent TV station Mtavari reported.
At least eight demonstrators were arrested in Georgia’s second-largest city, Batumi, local media said.
Opposition lawmakers have questioned the results of the election.
Brussels has demanded an investigation into what it said were “serious (electoral) irregularities.”
Pro-Western opposition parties are boycotting the new parliament, while President Salome Zurabishvili has sought to annul the election results through the country’s constitutional court.
In recent years, critics accuse Georgian Dream – in power for more than a decade – of having moved the country away from Europe and closer to Russia.
