Pfizer says its antiviral pill slashes risk of severe COVID-19 by 89 percent

Pfizer announced Friday it will soon ask the US Food and Drug Administration and international regulators to authorize its pill, which is taken twice a day for five days. (AP)
Short Url
Updated 05 November 2021
Follow

Pfizer says its antiviral pill slashes risk of severe COVID-19 by 89 percent

  • Pfizer's pill, with the brand name Paxlovid, could secure U.S. regulatory approval by the end of the year
  • President Joe Biden said the U.S. government has secured millions of doses of the Pfizer drug

DUBAI: Pfizer Inc’s experimental antiviral pill to treat COVID-19 was shown to cut by 89 percent the chances of hospitalization or death for adults at risk of developing severe disease, the company said on Friday.
It also comes as an offer to what could be a promising new weapon in the fight against the pandemic.
The trial’s results suggest that the oral drug surpasses Merck & Co. Inc’s pill, molnupiravir, which was shown last month to halve the risk of dying or being hospitalized for COVID-19 patients at high risk of serious illness.
Pfizer’s pill, with the brand name Paxlovid, could secure US regulatory approval by the end of the year. The Pfizer trial was stopped early due to its high success rate. Full trial data is not yet available from either company.
President Joe Biden said the US government has secured millions of doses of the Pfizer drug.
“If authorized by the FDA we may soon have pills that treat the virus in those who become infected,” Biden said. “The therapy would be another tool in our toolbox to protect people from the worst outcomes of COVID.”
Shares in Pfizer, which also makes one of the mostly widely used COVID-19 vaccines, were up 9 percent to $47.82, while Merck’s were down 9.3 percent to $82.09. Shares of vaccine makers took a hit, with Moderna Inc, Pfizer’s German partner BioNTech SE and Novavax all down 13-21 percent.
The pill is given in combination with an older antiviral called ritonavir. The treatment consists of three pills given twice daily. It has been in development for nearly two years.
Pfizer is in discussions with 90 countries over supply contracts for its pill, Chief Executive Officer Albert Bourla said in an interview.
Bourla said Pfizer expects to price its treatment close to where Merck has priced its pill. Merck’s US contract price for its pill is around $700 for a five-day course of therapy.
Even with the potential offered by the Pfizer and Merck pills, preventing COVID-19 infections through broad use of vaccines remains the best way to control a pandemic that has killed more than 5 million people worldwide, including more than 750,000 in the United States, according to infectious disease experts.
“Vaccines are going to be the most effective and reliable tool that we have in this pandemic,” said Dr. Grace Lee, professor of pediatrics at Stanford University School of Medicine. “These oral medications are going to augment our ability to really reduce the risk of severe disease, hospitalization and death, which is huge, but it won’t prevent infection.”
While more than 7 billion vaccine doses have been administered worldwide, that has covered only about half the world’s people. In the United States, 58 percent of all people, including 70 percent of adults, are fully vaccinated. There are more than 400,000 new COVID-19 cases daily worldwide, with infections rising in 50 countries.
Mizuho analyst Vamil Divan forecast a “very minor impact” from the Pfizer drug on vaccination among people who do not want the vaccine or a booster shot as recommended by US health regulators.
“I think there’s a small percentage of people that may decide not to get vaccinated, now that there are good treatment options,” Divan said.
Pfizer said it plans to submit interim trial results for its pill to the Food and Drug Administration (FDA) before the US Thanksgiving holiday on Nov. 25.
The company said it expects to manufacture 180,000 treatment courses by the end of this year and at least 50 million courses by the end of next year, including 21 million in the first half of 2022.
Antivirals need to be given as early as possible, before an infection takes hold, to be most effective.
The planned analysis of 1,219 patients in Pfizer’s study examined hospitalizations or deaths among people diagnosed with mild to moderate COVID-19 with at least one risk factor for developing severe disease, such as obesity or older age.
Among those given Pfizer’s drug within three days of symptom onset, the pill lowered the chances of hospitalization or death for adults at risk of developing severe COVID-19 by 89 percent compared to patients who received a placebo. Among these patients, 0.8 percent were hospitalized and none died by 28 days after treatment, compared to a 7 percent hospitalization rate and seven deaths in the placebo group.
Rates were similar for patients treated within five days of symptoms: 1 percent of the treatment group was hospitalized, compared to 6.7 percent for the placebo group, which included 10 deaths. Pfizer said that works out to being 85 percent effective at preventing hospitalization or death.
An FDA panel of outside experts is scheduled to meet Nov. 30 to discuss Merck’s pill, which was approved by British regulators https://www.reuters.com/business/health care-pharmaceuticals/britain-approves-mercks-oral-covid-19-pill-2021-11-04 in a world first on Thursday. Pfizer said it did not know if Paxlovid would be reviewed at that meeting.
Pfizer did not detail side any effects but said adverse events happened in about 20 percent of both treatment and placebo patients. Possible side effects include nausea and diarrhea.
Pfizer is holding discussions about a license for generic manufacturing of the pill for low-income countries, Unitaid’s Medicines Patent Pool said in a statement.


Russia planned ‘acts of terrorism’ in the air, Polish PM says

Updated 58 min 12 sec ago
Follow

Russia planned ‘acts of terrorism’ in the air, Polish PM says

  • The explosions occurred in depots in Britain, Germany and Poland in July
  • Russia has denied involvement in the incidents and Tusk did not mention them specifically

WARSAW: Russia planned ‘acts of terrorism’ in the air against Poland and other countries, Polish Prime Minister Donald Tusk said on Wednesday after meeting Ukrainian President Volodymyr Zelensky in Warsaw.
Security officials have said that parcels that exploded at logistics depots in Europe were part of a test run for a Russian plot to trigger explosions on cargo flights to the United States. The explosions occurred in depots in Britain, Germany and Poland in July. Russia has denied involvement in the incidents and Tusk did not mention them specifically.
“The latest information can confirm the validity of fears that Russia was planning acts of terrorism in the air not only against Poland,” Tusk told a news conference. He did not say what acts he was referring to or elaborate on the contents of the information.
Moscow has regularly denied any involvement in the courier depot explosions, as well as break-ins, arson and attacks on individuals which Western officials say were carried out by operatives paid by Russia. The Russian embassy in Warsaw has not immediately replied to an emailed request for comment on Tusk’s statement.


US must not become complacent to a growing terrorism threat, a Counterterrorism Center official says

Updated 15 January 2025
Follow

US must not become complacent to a growing terrorism threat, a Counterterrorism Center official says

  • “We are in a period where we are facing an elevated threat environment,” Holmgren said
  • He also points to mass migration from the Russia-Ukraine war that has sent central Asians to countries including Turkiye, Syria, Iraq and even the US

UNITED STATES: Brett Holmgren got woken up early on New Year’s Day by alerts that a driver had plowed into a crowd of revellers in New Orleans.
The rampage, which killed 14 people, was the deadliest attack on US soil in years and was inspired by the Daesh group.
The National Counterterrorism Center, which Holmgren leads, sprang into action to help the FBI run down information on the culprit from Texas and his plot.
It was a rare recent example of a mass attack motivated by religious extremism to hit the US homeland. But it didn’t occur in a vacuum, coming at a time when a terror threat that has waxed and waned in the two decades since the Sept. 11, 2001, attacks is decidedly on the rise around the world.
“We are in a period where we are facing an elevated threat environment,” Holmgren said in an interview with The Associated Press. “We faced that last year. We’re going to face it again in 2025.”
The NCTC emerged in the aftermath of 9/11 as a centralized US government hub to collect and analyze data and intelligence on the international terrorism threat, providing information to the White House and other agencies to shape policy decisions and protect against attacks.
A former counterterrorism analyst and assistant secretary of state, Holmgren was named its acting director last July and intends to step aside at the conclusion of the Biden administration.
At that point, new leadership under President-elect Donald Trump will grapple with managing some of the global hot spots like Syria that have vexed officials in recent months and that the NCTC has been tracking.
Holmgren cites multiple factors for why the threat is higher than before, including passions arising from the Israel-Hamas war — a conflict that he says has been a driving factor in some 45 attacks worldwide since October 2023. He also points to mass migration from the Russia-Ukraine war that has sent central Asians, some with ties to the Daesh group, to countries including Turkiye, Syria, Iraq and even the US
Around the world, officials are monitoring tensions in Africa, which Holmgren called potentially the greatest long-term threat to US security given that the Daesh group has a large footprint on the continent and is investing resources there.
He says the “most potent overseas threat facing the United States” right now is the group’s Afghanistan-based affiliate, known as Daesh-Khorasan, whose attacks include a March 2024 massacre at a Moscow theater and the August 2021 bombing that killed 13 US service members and about 170 Afghans in the chaotic US withdrawal from Afghanistan.
One ongoing spot of concern is Syria, where an insurgent group named Hayat Tahrir Al-Sham, or HTS, led a lightning offensive last month that toppled the government of President Bashar Assad.
HTS is a Sunni Islamist group that formerly had ties with Al-Qaeda, although its leader has preached religious coexistence since taking over in Damascus. The group has not plotted against US interests in recent years and has been “the most effective counterterrorism partner on the ground,” Holmgren said.
HTS has been designated by the State Department as a foreign terror organization, a label that carries severe sanctions.
Asked whether that designation would remain, Holmgren said that was a policy decision, though he noted: “They want to be perceived as being on the right side of the international community at this time when it comes to (counterterrorism). But we will continue to evaluate not just their words but also the actions that they’re undertaking.”
In an indication of Syria’s continued instability, Defense Secretary Lloyd Austin told The Associated Press last week that the US needs to keep troops there to prevent the Daesh group from reconstituting, and intelligence officials in Syria’s new de facto government already have thwarted a plan by Daesh to set off a bomb at a Shiite shrine in a Damascus suburb.
US officials, meanwhile, remain concerned about the possibility of Daesh gaining strength by taking over weapons left behind by Assad’s government or through a mass release of fighters who are now imprisoned.
“A large-scale prisoner release in Syria could provide a real boost in the arm for IS at a time where they have been under significant pressure,” Holmgren said.
The counterterrorism center’s focus is on international terrorism, which includes cases in the US like the New Orleans rampage in which the attacker was inspired by a group from abroad. The culprit, 42-year-old Shamsud-Din Jabbar, pledged his allegiance to Daesh in videos he recorded just before he drove his speeding pickup truck into a crowd on Bourbon Street early on Jan. 1.
As of now, Holmgren said, there’s no evidence that Jabbar was communicating with any Daesh operatives overseas or guided by anyone, but given that he was a lone actor who was radicalized, “this symbolizes exactly the type of attack that we’ve warned about for some time.”
“And I think it illustrates that while we have been quite effective as a government and across administrations at disrupting plotting overseas and going after terrorist leaders, we have a lot more work to do when it comes to countering violent extremism at home, countering violent extremist propaganda abroad,” he added.
“That is ultimately what is going to be needed to prevent more attacks like the one in New Orleans,” Holmgren said.
By the same token, through vast intelligence collection, hardened defenses and overseas counterterrorism operations, the US has made the risk of another large-scale attack like Sept. 11 lower than it’s ever been.
“But if we get complacent as a country,” he warned, “it will come back to bite us.”


South Korean investigators arrest President Yoon in insurrection probe

Updated 15 January 2025
Follow

South Korean investigators arrest President Yoon in insurrection probe

  • Yoon is the first sitting president in South Korean history to be arrested
  • His last month’s short-lived martial law order plunged the country into turmoil

SEOUL: South Korean authorities arrested President Yoon Suk-yeol on Wednesday over accusations of insurrection following his briefly imposed martial law.
The arrest ended a standoff between investigators and Yoon’s presidential security team, which had prevented his detention earlier this month.
The Corruption Investigation Office announced it had “executed an arrest warrant for President Yoon Suk-yeol today at 10:33 am,” after which he was seen stepping out of the car wearing a white shirt and suit as he slipped through the CIO’s back entrance for high-ranking officials.
“I decided to answer to the CIO’s investigations in order to prevent unsavory bloodshed,” Yoon said in a pre-recorded video statement released by his lawyers following the arrest.
“That does not mean I recognize the CIO’s investigation as legitimate.”
The CIO is leading a joint probe — together with military investigators and police — to probe allegations against Yoon.
He is charged with insurrection and will be held at the Seoul Detention Center. Authorities now have 48 hours to question the president and seek a warrant to detain him for up to 20 days.
The probe coincides with Yoon’s impeachment trial at the Constitutional Court. The trial began on Tuesday but hearings were adjourned minutes after it started due to Yoon’s absence.
The trial follows the National Assembly’s vote on Dec. 14 to impeach Yoon over the imposition of martial law on Dec. 3 — a move that lawmakers swiftly overturned hours after it was announced.
Yoon is the first sitting president in South Korean history to be arrested.
The CIO’s legitimacy in investigating Yoon has come under scrutiny as the president and his lawyers argue that it lacks the legal authority to investigate insurrection charges.
“The CIO does not have the right to investigate insurrection charges ... we strongly urge them to follow due legal processes,” Yoon’s lawyer and friend of 40-years, Seok Dong-hyun, said in a press conference after the president was taken into custody.
But Prof. Hong Young-ki from the Korea University School of Law told Arab News it was a matter of interpreting the law, “but the court has already confirmed the legitimacy” by approving the arrest warrant.
“The court already recognized the CIO’s jurisdiction when it issued the arrest warrant. Then who can go against the court and say that the CIO is illegitimate? How can a third party do it?” he said.
“The president wants to say that, but how can someone who was merely a prosecutor say his interpretation is more correct than that of the court? I don’t really think his argument has that much persuasive power.”
Claiming that the CIO’s investigation was illegitimate, Yoon was trying to evade arrest also during the eventually successful second attempt, which started at 4:10 a.m., with 3,000 officers surrounding his hillside house.
Buses and barbed wire were set up on the road leading to Yoon’s residence to prevent entry, while lawmakers from the president’s ruling People’s Power Party gathered at the site, tried to block the authorities, and shouted that “South Korea’s rule of law has collapsed” and that the “constitution has been destroyed.”
The opposition Democratic Party welcomed the arrest.
“A bit late, but it shows that South Korea’s governmental authority and justice is still alive,” floor leader Park Chan-dae said in a briefing.
“(Yoon’s arrest) is the first step in restoring liberal democracy and realizing the rule of law.”


South Korean investigators question President Yoon in insurrection probe

Updated 15 January 2025
Follow

South Korean investigators question President Yoon in insurrection probe

  • Yoon is the first sitting president in South Korean history to be arrested
  • His last month’s short-lived martial law order plunged the country into turmoil

Seoul: South Korean investigators began questioning President Yoon Suk-yeol on Wednesday after arresting him over accusations of insurrection following his briefly imposed martial law.

The arrest ended a standoff between investigators and Yoon’s presidential security team, which had prevented his detention earlier this month.

The Corruption Investigation Office announced it had “executed an arrest warrant for President Yoon Suk-yeol today at 10:33 am,” after which he was seen stepping out of the car wearing a white shirt and suit as he slipped through the CIO’s back entrance for high-ranking officials.

“I decided to answer to the CIO’s investigations in order to prevent unsavory bloodshed,” Yoon said in a pre-recorded video statement released by his lawyers following the arrest.

“That does not mean I recognize the CIO’s investigation as legitimate.”

The CIO is leading a joint probe — together with military investigators and police — to probe allegations against Yoon.

He is charged with insurrection and will be held at the Seoul Detention Center. Authorities now have 48 hours to question the president and seek a warrant to detain him for up to 20 days.

The probe coincides with Yoon’s impeachment trial at the Constitutional Court. The trial began on Tuesday, but hearings were adjourned minutes after it started due to Yoon’s absence.

The trial follows the National Assembly’s vote on Dec. 14 to impeach Yoon over the imposition of martial law on Dec. 3 — a move that lawmakers swiftly overturned hours after it was announced.

Yoon is the first sitting president in South Korean history to be arrested.

The CIO’s legitimacy in investigating Yoon has come under scrutiny as the president and his lawyers argue that it lacks the legal authority to investigate insurrection charges.

“The CIO does not have the right to investigate insurrection charges ... We strongly urge them to follow due legal processes,” Yoon’s lawyer and friend of 40 years, Seok Dong-hyun, said in a press conference after the president was taken into custody.

Prof. Hong Young-ki from the Korea University School of Law told Arab News it was a matter of interpreting the law, “but the court has already confirmed the legitimacy” by approving the arrest warrant.

“The court already recognized the CIO’s jurisdiction when it issued the arrest warrant. Then who can go against the court and say that the CIO is illegitimate? How can a third party do it?” he said.

“The president wants to say that, but how can someone who was merely a prosecutor say his interpretation is more correct than that of the court? I don’t really think his argument has that much persuasive power.”

Claiming that the CIO’s investigation was illegitimate, Yoon tried to evade arrest also during the eventually successful second attempt, which started at 4:10 a.m., with 3,000 officers surrounding his hillside house.

Buses and barbed wire were set up on the road leading to Yoon’s residence to prevent entry, while lawmakers from the president’s ruling People’s Power Party gathered at the site, tried to block the authorities, and shouted that “South Korea’s rule of law has collapsed” and that the “constitution has been destroyed.”

The opposition Democratic Party welcomed the arrest.

“A bit late, but it shows that South Korea’s governmental authority and justice is still alive,” floor leader Park Chan-dae said in a briefing.

“(Yoon’s arrest) is the first step in restoring liberal democracy and realizing the rule of law.”


Dense fog over Indian capital delays flights, trains

Updated 15 January 2025
Follow

Dense fog over Indian capital delays flights, trains

  • Visibility at Delhi’s main airport was between zero to 100 meters, over 40 trains across northern India delayed 
  • Delhi was ranked as the world’s most polluted city in live rankings by Swiss group IQAir on Wednesday

Dense fog and cold weather delayed train and flight departures in several parts of northern India, including its capital New Delhi, on Wednesday.
India’s weather office issued an orange alert for Delhi, the second highest warning level, forecasting dense to very dense fog in many areas.
Visibility at Delhi’s main airport was between zero to 100 meters (328.08 ft), the weather office said, and more than 40 trains across northern India were delayed because of fog, local media reported.
Some aircraft departures from Delhi were delayed, airport authorities said on social media platform X, warning that flights lacking the CAT III navigation system that enables landing despite low visibility would face difficulties. Delhi’s main airport handles about 1,400 flights every day.
“Low visibility and fog over Delhi may lead to some delays,” the country’s largest airline IndiGo said in a social media post.
Local media showed images of vehicles crawling along highways through the fog, and people huddled indoors as the temperature dipped to 7 degrees Celsius (44.6 degrees Fahrenheit).
Delhi was ranked as the world’s most polluted city in live rankings by Swiss group IQAir on Wednesday, with a reading of 254, ranked as “very unhealthy.”
The Indian capital has been battling poor air quality and smog since the beginning of winter.